Results 21 to 30 of about 7,527 (194)

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance A high frequency of missense mutations was recently discovered at histone H3.3 glycine 34 in 92% of giant cell tumors of the bone and 17% of high-grade astrocytomas. The molecular mechanism by which G34 mutations drive these tumors remains unclear.
Dylan Marchione, Charles David Allis, Nikoleta Juretić   +2 more
exaly   +3 more sources

Gynaecology Teaching Associates in Medical Education—A Scoping Review [PDF]

The Clinical Teacher, Volume 23, Issue 4, August 2026.
ABSTRACT Background Pelvic examination is a core, yet anxiety‐provoking, clinical skill in undergraduate medical education. Traditional teaching approaches—often opportunistic or reliant on simulation—have been criticised for disembodying technical skill from relational and ethical practice. Gynaecology Teaching Associates (GTAs), trained educators who
Caitlin Kelly, Emily Bell, Megan E. L. Brown, Heidi Stelling   +3 more
wiley   +2 more sources

H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components

Acta Neuropathologica Communications, 2019
The recently described malignant neuro-epithelial tumors with histone H3F3A point mutations at G34 (NET-H3-G34) occur most often in cerebral hemispheres of teenagers and young adults, and have a generally adverse prognosis.
Felipe Andreiuolo, Tomo Lisner, Jozef Zlocha, Christof Kramm, Arend Koch, Brigitte Bison, Albane Gareton, Marc Zanello, Andreas Waha, Pascale Varlet, Torsten Pietsch   +10 more
doaj   +2 more sources

Colliding filaments in the molecular cloud G34

Astronomy & Astrophysics
The molecular cloud complex G34 is located at a distance of 2.12 ± 0.38 kpc and contains two giant filaments, F1 and F2. It is considered a good example of colliding filaments. We mapped these two filaments using the 13CO and 12CO (J = 1−0) lines that were observed with the 13.7 m millimeter-wavelength telescope of the Purple Mountain Observatory.
Mingke Sun, Jarken Esimbek, Christian Henkel, Jianjun Zhou, Gang Wu, Yuxin He, Dalei Li, Xindi Tang, Toktarkhan Komesh, Yingxiu Ma, Kadirya Tursun, Dongdong Zhou, Willem Baan, Andrej M. Sobolev, Qaynar Jandaolet, Serikbek Sailanbek   +15 more
openaire   +3 more sources

Immunohistochemistry as a tool for identifying PDGFRA amplification in central nervous system tumors [PDF]

Brain Pathology, EarlyView.
PDGFRA gene amplification is now recognized as a diagnostically and prognostically relevant molecular alteration in central nervous system tumors. Herein, we demonstrated that PDGFRA immunohistochemistry is a highly specific and sensitive biomarker for identifying PDGFRA amplification and should be part of the neuropathologist's routine panel of ...
Arnault Tauziède‐Espariat, Guilhem Amargos, Farah Sassi, Lauren Hasty, Alice Métais, Pascale Varlet   +5 more
wiley   +2 more sources

Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis [PDF]

Journal of Molecular Biology, 2018
Histone H3 encoding genes, particularly H3F3A and H3F3B, the genes encoding the variant histone H3.3, are mutated at high frequency in pediatric brain and bone malignancies. Compared to the extensive studies on K27M and K36M mutations, little is known about the mechanism of G34 mutations found in pediatric glioblastoma or giant cell tumors of the bone.
Xiaobing Shi, Hong Wen, Jiejun Shi
exaly   +3 more sources

ESO 546-G34: the most-metal-poor, low surface brightness galaxy? [PDF]

Monthly Notices of the Royal Astronomical Society: Letters, 2011
Abstract We present a re-analysis of spectroscopic data for 23 H ii regions in 12 blue, metal-poor, low surface brightness galaxies (LSBGs), taking advantage of recent developments in calibrating strong-line methods. In doing so, we have identified a galaxy (ESO 546−G34) which may be the most-metal-poor LSBG found in the local Universe ...
Mattsson, Lars, Pilyugin, L.S., Bergvall, Nils   +2 more
openaire   +3 more sources

Imaging features and consideration of progression pattern of diffuse hemispheric gliomas, H3 G34-mutant

Acta Neuropathologica Communications
Diffuse hemispheric glioma H3 G34-mutant (DHG) has been identified as a distinct pediatric-type high-grade glioma, according to the World Health Organization (WHO) classification of central nervous system tumors. Widely accepted treatment options include surgery, radiation, and conventional chemotherapy.
Yuji Kibe, Lushun Chalise, Fumiharu Ohka, Kazuya Motomura, Norimoto Nakahara, Kosuke Aoki, Shoichi Deguchi, Yoshiki Shiba, Kazuhito Takeuchi, Kenichiro Iwami, Junya Yamaguchi, Hiroki Shimizu, Sachi Maeda, Yuhei Takido, Ryo Yamamoto, Yusuke Okuno, Akihiro Sakai, Kennosuke Karube, Ryuta Saito   +18 more
openaire   +4 more sources

Corporate governance and remuneration: a bibliometric analysis [PDF]

Journal of Asian Business and Economic Studies, 2021
Purpose – This study aims to pinpoint gaps in the literature on corporate governance and remuneration by producing a comprehensive bibliometric review for the period 1990–2020. Design/methodology/approach – Bibliometric analysis is the quantitative study
Jinnatul Raihan Mumu, Paolo Saona, Hasibul Islam Russell, Md. Abul Kalam Azad   +3 more
doaj   +1 more source

Board governance quality and risk disclosure compliance among financial institutions in Uganda [PDF]

Journal of Asian Business and Economic Studies, 2021
Purpose – This paper aims to examine the impact of board governance quality (BGQ) and its mechanisms, namely board activity, board independence, board communication and board expertise, on the level of risk disclosure compliance (RDC) among financial ...
Geofrey Nkuutu, Joseph Mpeera Ntayi, Isaac Nabeeta Nkote, John Munene, Will Kaberuka   +4 more
doaj   +1 more source