Results 11 to 20 of about 6,956 (212)
A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon [PDF]
npj Precision OncologyDiffuse hemispheric glioma H3 G34-mutant is primarily diagnosed in adolescents/young adults. While molecular diagnostics have improved, cellular mechanisms that drive tumor progression and therapy resistance are poorly understood.
Cameron Crowell +30 more
doaj +3 more sources
ESO 546-G34: the most-metal-poor, low surface brightness galaxy? [PDF]
Monthly Notices of the Royal Astronomical Society: Letters, 2011 Abstract We present a re-analysis of spectroscopic data for 23 H ii regions in 12 blue, metal-poor, low surface brightness galaxies (LSBGs), taking advantage of recent developments in calibrating strong-line methods. In doing so, we have identified a galaxy (ESO 546−G34) which may be the most-metal-poor LSBG found in the local Universe ...
Lars Mattsson +2 more
exaly +4 more sources
H3 G34-mutant high-grade glioma [PDF]
Brain Tumor Pathology, 2020 H3F3A G34 (H3.3 G34)-mutant high-grade gliomas (HGG) are rare, and newly recognized infiltrating gliomas of the cerebral hemisphere. Here, we report the clinicopathological and molecular characteristics of four H3.3 G34-mutant gliomas in terms of its biological behavior compared to those of glioblastomas (GBMs) and H3 K27M-mutant diffuse midline ...
Ka Young Lim +2 more
exaly +6 more sources
G34, Another Connection between MYCN and a Pediatric Tumor [PDF]
Cancer Discovery, 2013 Abstract Summary: Recurrent mutations in H3F3A at K27 and G34 are frequent in pediatric glioblastoma, but it is unclear how these mutations promote tumorigenesis. In this issue of Cancer Discovery, Bjerke and colleagues identify mutations at G34 in H3F3A that result in elevated expression of MYCN as a potential mechanism in gliomagenesis.
Huang, Miller, Weiss, William A
openaire +6 more sources
Case Report: Evolutionary Clinical-Radiological Features of a Diffuse Hemispheric Glioma, H3 G34 Mutant with Over 5 Years of Survival [PDF]
Case Reports in Oncology, 2023 Diffuse hemispheric glioma (DHG), H3 G34 mutant was included in the 5th edition of the World Health Organization Classification of Tumors of the Central Nervous System recently published.
Camilla A.F. Yamada +6 more
doaj +2 more sources
Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults [PDF]
Neuro-Oncology Advances, 2021 Abstract Background Diffuse hemispheric gliomas, H3 G34-mutant (DHG H3G34-mutant) constitute a distinct type of aggressive brain tumors. Although initially described in children, they can also affect adults.
Thiébaud Picart +17 more
openaire +5 more sources
A tRNA-mimic Strategy to Explore the Role of G34 of tRNAGly in Translation and Codon Frameshifting [PDF]
International Journal of Molecular Sciences, 2019 Decoding of the 61 sense codons of the genetic code requires a variable number of tRNAs that establish codon-anticodon interactions. Thanks to the wobble base pairing at the third codon position, less than 61 different tRNA isoacceptors are needed to decode the whole set of codons.
Aurélie Janvier +5 more
openaire +4 more sources
Acta Neuropathologica Communications, 2019 The recently described malignant neuro-epithelial tumors with histone H3F3A point mutations at G34 (NET-H3-G34) occur most often in cerebral hemispheres of teenagers and young adults, and have a generally adverse prognosis.
Felipe Andreiuolo +10 more
doaj +2 more sources
The clinical and molecular landscape of diffuse hemispheric glioma, H3 G34-mutant. [PDF]
Neuro OncolAbstract Background Diffuse hemispheric glioma, histone 3 (H3) G34-mutant, has been newly defined in the 2021 World Health Organization (WHO) classification of central nervous system tumors. Here we sought to define the prognostic roles of clinical, neuroimaging, pathological, and molecular features ...
Le Rhun E +38 more
europepmc +7 more sources
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance A high frequency of missense mutations was recently discovered at histone H3.3 glycine 34 in 92% of giant cell tumors of the bone and 17% of high-grade astrocytomas. The molecular mechanism by which G34 mutations drive these tumors remains unclear.
Siddhant U Jain +2 more
exaly +3 more sources