Results 11 to 20 of about 7,730 (210)

H3 G34-mutant high-grade glioma [PDF]

Brain Tumor Pathology, 2020
H3F3A G34 (H3.3 G34)-mutant high-grade gliomas (HGG) are rare, and newly recognized infiltrating gliomas of the cerebral hemisphere. Here, we report the clinicopathological and molecular characteristics of four H3.3 G34-mutant gliomas in terms of its biological behavior compared to those of glioblastomas (GBMs) and H3 K27M-mutant diffuse midline ...
Ka Young Lim, Jae Kyung Won, Chul-Kee Park, Seung-Ki Kim, Seung Hong Choi, Taemin Kim, Hongseok Yun, Sung-Hye Park   +7 more
core   +8 more sources

Integrated high-resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34-mutant reveals universal TP53 abnormalities. [PDF]

Brain Pathol
This integrated high‐resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34‐mutant expands the spectrum of associated genetic changes and underscores the presence of universal TP53 abnormalities at copy number, sequence, and protein expression level, with frequent yet largely unrecognized TP53 copy‐neutral loss of ...
Trejo-Lopez JA, Mendoza CZ, Kollmeyer TM, Drucker KL, Pazdernik VM, Decker PA, Praska CE, Hardcastle J, Smoley S, Isaacson M, Gandham M, Dasari S, Raghunathan A, Giannini C, Zheng G, Wagner A, Lopes MB, Fung KA, Peterson JG, Rivera AL, Rossi C, Walsh MA, Abdullaev Z, Aldape K, Quezado M, Pratt D, Cimino PJ, Jenkins RB, Ida CM.   +28 more
europepmc   +3 more sources

G34, Another Connection between MYCN and a Pediatric Tumor [PDF]

Cancer Discovery, 2013
Abstract Summary: Recurrent mutations in H3F3A at K27 and G34 are frequent in pediatric glioblastoma, but it is unclear how these mutations promote tumorigenesis. In this issue of Cancer Discovery, Bjerke and colleagues identify mutations at G34 in H3F3A that result in elevated expression of MYCN as a potential mechanism in gliomagenesis.
Huang, Miller, Weiss, William A
openaire   +6 more sources

The clinical and molecular landscape of diffuse hemispheric glioma, H3 G34-mutant. [PDF]

Neuro Oncol
Abstract Background Diffuse hemispheric glioma, histone 3 (H3) G34-mutant, has been newly defined in the 2021 World Health Organization (WHO) classification of central nervous system tumors. Here we sought to define the prognostic roles of clinical, neuroimaging, pathological, and molecular features ...
Le Rhun E, Bink A, Felsberg J, Gramatzki D, Brandner S, Benhamida JK, Wick A, Tonn JC, Mohme M, Tabatabai G, Capper D, Snuderl M, Razis E, Ronellenfitsch MW, Neidert N, Ng HK, Pohl U, Bale T, Quach S, Rieger D, Schüller U, Onken J, Drüschler K, Maurage CA, Regli L, Healy E, Graham M, Hortobagyi T, Paine S, Bridges L, Lausova T, Medici V, Sievers P, Schrimpf D, Wick W, Sahm F, Reifenberger G, von Deimling A, Weller M.   +38 more
europepmc   +8 more sources

A tRNA-mimic Strategy to Explore the Role of G34 of tRNAGly in Translation and Codon Frameshifting [PDF]

International Journal of Molecular Sciences, 2019
Decoding of the 61 sense codons of the genetic code requires a variable number of tRNAs that establish codon-anticodon interactions. Thanks to the wobble base pairing at the third codon position, less than 61 different tRNA isoacceptors are needed to decode the whole set of codons.
Janvier, A, Despons, L, Schaeffer, Laure, Tidu, A, Martin, Franck, Eriani, Gilbert   +5 more
openaire   +5 more sources

H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components

Acta Neuropathologica Communications, 2019
The recently described malignant neuro-epithelial tumors with histone H3F3A point mutations at G34 (NET-H3-G34) occur most often in cerebral hemispheres of teenagers and young adults, and have a generally adverse prognosis.
Felipe Andreiuolo, Tomo Lisner, Jozef Zlocha, Christof Kramm, Arend Koch, Brigitte Bison, Albane Gareton, Marc Zanello, Andreas Waha, Pascale Varlet, Torsten Pietsch   +10 more
doaj   +2 more sources

Anatomic Staging of H3 G34-Mutant Diffuse Hemispheric Glioma

Neurology
H3 G34-mutant diffuse hemispheric gliomas are rare, aggressive primary brain tumors predominantly affecting young patients. We investigated the prognostic value of anatomic staging (AS)-a system previously validated in adult-type diffuse gliomas-in this molecularly distinct tumor type.Patients from an international cohort with H3 G34-mutant gliomas ...
Kevin Akeret, Luis Padevit, Guido Reifenberger, Andreas von Deimling, Michael Weller, Emilie Le Rhun, Andrea Bink, Joerg Felsberg, Dorothee Gramatzki, Sebastian Brandner, Jamal K. Benhamida, Antje Wick, Joerg C. Tonn, Malte Mohme, Ghazaleh Tabatabai, David Capper, Matija Snuderl, Evangelia Razis, Michael W. Ronellenfitsch, Nicolas Neidert, Ho-Keung Ng, Ute Pohl, Tejus Bale, Stefanie Quach, David Rieger, Ulrich Schüller, Julia Onken, Katharina Drüschler, Claude-Alain Maurage, Luca Regli, Estelle Healy, Maya Graham, Tibor Hortobagyi, Simon Paine, Leslie Bridges, Tereza Lausova, Valentina Medici, Philipp Sievers, David Schrimpf, Wolfgang Wick, Felix Sahm   +40 more
core   +5 more sources

Gynaecology Teaching Associates in Medical Education-A Scoping Review. [PDF]

Clin Teach
ABSTRACT Background Pelvic examination is a core, yet anxiety‐provoking, clinical skill in undergraduate medical education. Traditional teaching approaches—often opportunistic or reliant on simulation—have been criticised for disembodying technical skill from relational and ethical practice. Gynaecology Teaching Associates (GTAs), trained educators who
Kelly C, Bell E, Brown MEL, Stelling H.
europepmc   +2 more sources

Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults [PDF]

Neuro-Oncology Advances, 2021
Abstract Background Diffuse hemispheric gliomas, H3 G34-mutant (DHG H3G34-mutant) constitute a distinct type of aggressive brain tumors. Although initially described in children, they can also affect adults.
Thiébaud Picart, Marc Barritault, Delphine Poncet, Lise-Prune Berner, Cristina Izquierdo, Emeline Tabouret, Dominique Figarella-Branger, Ahmed Idbaïh, Franck Bielle, Véronique Bourg, Fanny Burel Vandenbos, Elizabeth Cohen-Jonathan Moyal, Emmanelle Uro-Coste, Jacques Guyotat, Jérôme Honnorat, Mathieu Gabut, David Meyronet, François Ducray   +17 more
openaire   +3 more sources

Immunohistochemistry as a tool for identifying PDGFRA amplification in central nervous system tumors. [PDF]

Brain Pathol
PDGFRA gene amplification is now recognized as a diagnostically and prognostically relevant molecular alteration in central nervous system tumors. Herein, we demonstrated that PDGFRA immunohistochemistry is a highly specific and sensitive biomarker for identifying PDGFRA amplification and should be part of the neuropathologist's routine panel of ...
Tauziède-Espariat A, Amargos G, Sassi F, Hasty L, Métais A, Varlet P.   +5 more
europepmc   +2 more sources