Results 1 to 10 of about 6,000 (174)

H3 G34-mutant high-grade glioma [PDF]

Brain Tumor Pathology, 2020
H3F3A G34 (H3.3 G34)-mutant high-grade gliomas (HGG) are rare, and newly recognized infiltrating gliomas of the cerebral hemisphere. Here, we report the clinicopathological and molecular characteristics of four H3.3 G34-mutant gliomas in terms of its biological behavior compared to those of glioblastomas (GBMs) and H3 K27M-mutant diffuse midline ...
Taemin Kim, Ka Young Lim, Woo Hyeon Lim
exaly   +8 more sources

Pediatric diffuse hemispheric glioma H3 G34-mutant with gains of the BRAF locus: An illustrative case

Rare Tumors, 2023
Diffuse hemispheric glioma, H3 G34-mutant, is a recently recognized distinct high-grade glioma with a dismal prognosis. In addition to the H3 G34 missense mutation, numerous genetic events have been identified in these malignant tumors, including ATRX ...

exaly   +2 more sources

A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon [PDF]

npj Precision Oncology
Diffuse hemispheric glioma H3 G34-mutant is primarily diagnosed in adolescents/young adults. While molecular diagnostics have improved, cellular mechanisms that drive tumor progression and therapy resistance are poorly understood.
Cameron Crowell, Ziwen Zhu, Yingxiang Li, Maria L. Varela, Quinn Ostrom, Patrick J. Cimino, Sohil H. Patel, Suzanne J. Baker, Chetan Bettegowda, Houtan Noushmehr, Claudia L. Kleinman, Laura Canty, Gustavo Alencastro Veiga Cruzeiro, Anandani Nellan, Oren Becher, Tom B. Davidson, Dolores Hambardzumyan, Adam Green, Robert Thorne, Kelli Wilson, Brett Theeler, Jason Gregory, Peter Mathen, Nadia Biassou, Sheila McThenia, Craig Erker, Robert Galvin, Ariane Soldatos, Pedro R. Lowenstein, Maria G. Castro, Sadhana Jackson   +30 more
doaj   +2 more sources

The clinical and molecular landscape of diffuse hemispheric glioma, H3 G34-mutant. [PDF]

Neuro Oncol
Abstract Background Diffuse hemispheric glioma, histone 3 (H3) G34-mutant, has been newly defined in the 2021 World Health Organization (WHO) classification of central nervous system tumors. Here we sought to define the prognostic roles of clinical, neuroimaging, pathological, and molecular features ...
Le Rhun E, Bink A, Felsberg J, Gramatzki D, Brandner S, Benhamida JK, Wick A, Tonn JC, Mohme M, Tabatabai G, Capper D, Snuderl M, Razis E, Ronellenfitsch MW, Neidert N, Ng HK, Pohl U, Bale T, Quach S, Rieger D, Schüller U, Onken J, Drüschler K, Maurage CA, Regli L, Healy E, Graham M, Hortobagyi T, Paine S, Bridges L, Lausova T, Medici V, Sievers P, Schrimpf D, Wick W, Sahm F, Reifenberger G, von Deimling A, Weller M.   +38 more
europepmc   +7 more sources

Multiscale Dynamical Scenario of High-mass Star Formation in an IRDC Filament G34

The Astrophysical Journal, 2023
There is growing evidence that high-mass star formation (HMSF) is a multiscale, dynamical process in molecular clouds, where filaments transport gas material between larger and smaller scales.
Sirong Pan, Hong-Li Liu, Sheng-Li Qin
doaj   +3 more sources

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance A high frequency of missense mutations was recently discovered at histone H3.3 glycine 34 in 92% of giant cell tumors of the bone and 17% of high-grade astrocytomas. The molecular mechanism by which G34 mutations drive these tumors remains unclear.
Dylan Marchione, Charles David Allis, Nikoleta Juretić   +2 more
exaly   +3 more sources

Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis [PDF]

Journal of Molecular Biology, 2018
Histone H3 encoding genes, particularly H3F3A and H3F3B, the genes encoding the variant histone H3.3, are mutated at high frequency in pediatric brain and bone malignancies. Compared to the extensive studies on K27M and K36M mutations, little is known about the mechanism of G34 mutations found in pediatric glioblastoma or giant cell tumors of the bone.
Xiaobing Shi, Hong Wen, Jiejun Shi
exaly   +3 more sources

ESO 546-G34: the most-metal-poor, low surface brightness galaxy? [PDF]

Monthly Notices of the Royal Astronomical Society: Letters, 2011
Abstract We present a re-analysis of spectroscopic data for 23 H ii regions in 12 blue, metal-poor, low surface brightness galaxies (LSBGs), taking advantage of recent developments in calibrating strong-line methods. In doing so, we have identified a galaxy (ESO 546−G34) which may be the most-metal-poor LSBG found in the local Universe ...
Leonid Stepanovich Pilyugin, Lars Mattsson, Nils Bergvall   +2 more
exaly   +3 more sources

Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults [PDF]

Neuro-Oncology Advances, 2021
Abstract Background Diffuse hemispheric gliomas, H3 G34-mutant (DHG H3G34-mutant) constitute a distinct type of aggressive brain tumors. Although initially described in children, they can also affect adults.
Thiébaud Picart, Marc Barritault, Delphine Poncet, Lise-Prune Berner, Cristina Izquierdo, Emeline Tabouret, Dominique Figarella-Branger, Ahmed Idbaïh, Franck Bielle, Véronique Bourg, Fanny Burel Vandenbos, Elizabeth Cohen-Jonathan Moyal, Emmanelle Uro-Coste, Jacques Guyotat, Jérôme Honnorat, Mathieu Gabut, David Meyronet, François Ducray   +17 more
openaire   +3 more sources

MPC-5 Characteristics of H3 G34-mutant gliomas [PDF]

Neuro-Oncology Advances, 2021
Abstract Introduction: Diffuse hemispheric gliomas, H3 G34-mutant (DHG H3G34-mutant) are newly recognized infiltrating gliomas of the cerebral hemispheres of pediatric and young adult patients. We experienced 6 DHG H3G34-mutant cases. In this study, we describe the clinical, radiological and pathological characteristics of these cases.
Kibe, Yuji, Ohka, Fumiharu, Motomura, Kazuya, Aoki, Kosuke, Maeda, Sachi, Hirano, Masaki, Nishikawa, Tomohide, Yamaguchi, Junya, Yamazaki, Shintaro, Natsume, Atsushi, Saito, Ryuta   +10 more
openaire   +1 more source