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Functional and structural analysis of double and triple mutants reveals the contribution of protein instability to clinical manifestations of G6PD variants

International Journal of Biological Macromolecules, 2020
USA Boonyuen, Mallika Imwong
exaly

Variation in G6PD activity and the protective effect of G6PD deficiency

Glucose–6–Phosphate Dehydrogenase (G6PD) is the rate limiting enzyme of the pentose phosphate pathway (PPP), that protects human cells from oxidative stress. There are few reports that suggest that G6PD activity is not stable but varies, possibly due to external factors, though this topic is sparsely explored to date.
openaire +1 more source

ORIGIN OF G6PD POLYMORPHISM: MALARIA AND G6PD DEFICIENCY

1986
Lucio Luzzatto +3 more
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A computational study of structural differences of binding of NADP+ and G6P substrates to G6PD Mediterraneanc.563T, G6PD A−c.202A/c.376G, G6PD Cairoc.404C and G6PD Gazac.536A mutations

Blood Cells, Molecules, and Diseases, 2021
Hariprasad Vankayalapati, Josef Prchal, N Scott Reading +2 more
exaly

G6PD Deficiency

Don't Forget The Bubbles, 2023
openaire +1 more source

G6PD Varadero