Results 101 to 110 of about 1,019,197 (220)

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania.

PLoS ONE, 2019
BackgroundPrimaquine is recommended by the World Health Organization (WHO) for radical treatment of Plasmodium vivax malaria. This drug is known to provoke acute hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency ...
Oum Kelthoum Mamadou Djigo, Mohamed Abdallahi Bollahi, Moina Hasni Ebou, Mohamed Salem Ould Ahmedou Salem, Rachida Tahar, Hervé Bogreau, Leonardo Basco, Ali Ould Mohamed Salem Boukhary   +7 more
doaj   +1 more source

Prevalência da deficiência da glicose-6-fosfato desidrogenase em doadores de sangue de Mossoró, Rio Grande do Norte Prevalence of glucose-6-phosphate dehydrogenase deficiency in blood donors of Mossoró, Rio Grande do Norte

Revista Brasileira de Hematologia e Hemoterapia, 2010
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. It affects as many as 330 million individuals worldwide.
Ulysses Madureira Maia, Danielle Cristiny de Azevedo Batista, Wogelsanger Oliveira Pereira, Thales Allyrio Araújo de Medeiros Fernandes   +3 more
doaj   +1 more source

Pyruvate kinase deficiency and G6PD deficiency

SEIBUTSU BUTSURI KAGAKU, 1978
G6PD deficiency was discovered in 1956. It causes drug-induced acute hemolysis and is inherited by a sex-linked recessive trait. While the disorder is frequently seen in Negroes and inhabitants around the Mediterranean basin, it is rare in Japanese, the frequency of which is about 0.1%.
openaire   +2 more sources

G6PD deficiency, primaquine treatment, and risk of haemolysis in malaria-infected patients

Malaria Journal, 2018
The incidence of malaria in the Americas has decreased markedly in recent years. Honduras and the other countries of Mesoamerica and the island of Hispaniola have set the goal of eliminating native malaria by the year 2020. To achieve this goal, Honduras
Sara Avalos, R. Mejía, Engels I Banegas, C. Salinas, Lester Gutiérrez, M. Fajardo, S. Galo, A. Pinto, Ángel Mejía, G. Fontecha   +9 more
semanticscholar   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Prevalence of glucose-6-phosphate dehydrogenase deficiency in neonates in Egypt

Annals of Saudi Medicine, 2017
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder which causes neonatal jaundice in most cases, and under certain conditions, can cause a spectrum of hemolytic manifestations.
Soheir Abo Elella, Mahaa Tawfik, Naglaa Barseem, Wafaa Moustafa   +3 more
doaj   +1 more source

Glucose-6-phosphate dehydrogenase (G6PD) deficiency in Ethiopia: absence of common African and Mediterranean allelic variants in a nationwide study

Malaria Journal, 2018
Building on the declining trend of malaria in Ethiopia, the Federal Ministry of Health aims to eliminate malaria by 2030. As Plasmodium falciparum and Plasmodium vivax are co-endemic in Ethiopia, the use of primaquine is indicated for both transmission ...
A. Assefa, A. Ali, W. Deressa, Wendimagegn Tsegaye, G. Abebe, H. Sime, A. Kebede, D. Jima, M. Kassa, T. Abreha, Hiwot Teka, H. Solomon, J. Malone, Y. Shi, Zhiyong Zhou, R. Reithinger, Jimee Hwang   +16 more
semanticscholar   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Cross Sectional Study of Prenatal Diagnosis Uptake Among Individuals With Genetic Conditions

Prenatal Diagnosis, Volume 46, Issue 9, Page 1374-1384, August 2026.
ABSTRACT Objective Prenatal diagnostic genetic testing allows for early identification of significant fetal conditions and enables informed decision‐making regarding management options. The aim of this study was to assess prenatal testing practice among individuals with genetic conditions.
Ebunoluwa Ojo, Roni Zemet, Allyson Nevins, Katherine Abraham, April D. Adams   +4 more
wiley   +1 more source