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Oxygen metabolism abnormalities and high-altitude cerebral edema. [PDF]

Front Immunol
Li Z, Zhang J, Zhang X, Jin Q, Zheng X, Mo L, Da Z.   +6 more
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Ganglioside G_M1-Mediated Amyloid-beta Fibrillogenesis and Membrane Disruption

Biochemistry, 2007
There is increasing evidence that a class of cell membrane glycolipids, gangliosides, can mediate the fibrillogenesis and toxicity of Alzheimer's disease amyloid-beta peptide (Abeta). Using lipid monolayers and vesicles as model membranes, we measured the insertion of Abeta into 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)-ganglioside GM1 ...
Eva Y, Chi, Shelli L, Frey, Ka Yee C, Lee   +2 more
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GM1-ganglioside degradation and biosynthesis in human and murine GM1-gangliosidosis

Clinica Chimica Acta, 2005
Gangliosides are building blocks of cell membranes and their biosynthesis and degradation have been extensively studied in the past. Regulation of the metabolism of these glycolipids controls fundamental cell functions. G(M1)-gangliosidosis, a neurodegenerative glycosphingolipid storage disease, is caused by deficiency of lysosomal beta-galactosidase ...
Renata, Sano, Vera M T, Trindade, Alessandra, Tessitore, Alessandra, d'Azzo, Matheus B, Vieira, Roberto, Giugliani, Janice C, Coelho   +6 more
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Distribution of Ganglioside G_M1 between Two-Component, Two-Phase Phosphatidylcholine Monolayers

Langmuir, 1998
The distribution of the ganglioside GM1, at low concentrations, in phase-separated 1:1 dioleoyl phosphatidylcholine (DOPC)/dipalmitoylphosphatidylcholine (DPPC) Langmuir−Blodgett (LB) films transfe...
V. Vié, N. Van Mau, E. Lesniewska, J. P. Goudonnet, F. Heitz, C. Le Grimellec   +5 more
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A Radioassay for G_M1 Ganglioside Concentration in Cerebrospinal Fluid

Journal of Neurochemistry, 1980
Abstract:A radioassay for the rapid determination of GM1, ganglioside concentration in small volumes of CSF from individual patients is described. The assay utilizes the high‐affinity interaction between cholera enterotoxin and GM1 ganglioside. The lower detection limit of GM1 ganglioside by this radioassay under the described incubation conditions is ...
E, Ginns, J, French
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Biological activity of preformed cholera toxin‐ganglioside G_M1 complex

Journal of Neuroscience Research, 1984
AbstractSynthetic and natural amphiphiles, octyl glucoside, Nonidet P40, sodium dodecyl sulfate (SDS), gangliosides GM1 and GD1a, interact with cholera toxin (CLT) and with its active region (protomer A). The formation of CLT‐amphiphile complex leads to inhibition of ADP‐ribosyltransferase activity, a characteristic of protomer A elicited after thiol ...
M L, Fiani, P, Macioce, A, Gallina, M, Tomasi   +3 more
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Fixation and Inactivation of Cholera Toxin by G_M1Ganglioside

Scandinavian Journal of Infectious Diseases, 1973
AbstractCholera exo-enterotoxin was fixed and inactivated by pure GM1 ganglioside (Galβ1−3GalNAcβ1−4(NANβ2−3)Galβ1−4Glc-Cer) in stoichiometric proportions. This indicates that GM1 may be the tissue receptor for the toxin.
J, Holmgren, I, Lönnroth, L, Svennerholm   +2 more
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Preparation and Properties of Antibodies to G_D3 and G_M1 Gangliosides

Journal of Neurochemistry, 1980
Abstract: Gangliosides GD3 and GM1 were coupled to proteins by their car‐boxyl groups and antisera were raised against the complexes. Anti‐ganglioside antibodies were isolated by affinity chromatography on ganglioside‐amino‐propyl silica gel columns and the specificity of the antibodies was determined by a quantitative microcomplement fixation assay ...
S K, Kundu, D M, Marcus, R W, Veh
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G _M1 Ganglioside Treatment Facilitates Behavioral Recovery from Bilateral Brain Damage

Science, 1984
Adult rats with bilateral lesions of the caudate nucleus were treated with G M1 ganglioside. Although animals injected with a control solution were severely impaired in their ability to learn a complex spatial task, those treated with ganglioside were able to learn spatial reversals.
B A, Sabel, M D, Slavin, D G, Stein
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Cholera Toxin: Interaction of Subunits with Ganglioside G _M1

Science, 1974
Vibrio cholerae exotoxin is an aggregate of two different noninterconvertible subunits (molecular weights about 15,000 and about 25,000). Only the smaller subunit reacts with ganglioside G M1 , a possible biological receptor.
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