Results 151 to 160 of about 5,214 (181)

Direct Evidence That Endogenous G _M1 Ganglioside Can Mediate Thymocyte Proliferation

Science, 1985
The B subunit of cholera toxin, which is multivalent and binds exclusively to a specific ganglioside, G M1 , was mitogenic for rat thymocytes. When exposed to the B subunit, the cells proliferated, as measured by 3 H-labeled thymidine incorporation.
S, Spiegel, P H, Fishman, R J, Weber
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Ganglioside G_M1and Hydrophilic Polymers Increase Liposome Circulation Times by Inhibiting the Association of Blood Proteins

Journal of Liposome Research, 1992
AbstractSeveral agents have been shown to prolong the circulation lifetime of liposomes. These agents, such as ganglioside GM1 or phosphatidylethanolamine-derivatives of monomethoxypolyethyleneglycols, provide insight into the mechanism(s) by which liposomes are cleared from the circulation.
Arcadio Chonn, Pieter R. Cullis
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Molecular Recognition and Colorimetric Detection of Cholera Toxin by Poly(diacetylene) Liposomes Incorporating G_m1 Ganglioside

Langmuir, 1997
Molecular recognition sites on cell membranes serve as the main communication channels between the inside of a cell and its surroundings. Upon receptor binding, celular messages such as ion channel opening or activation of enzymes are triggered. In this report, we demonstrate that artificial cell membranes made from conjugated lipid polymers (poly ...
John J. Pan, Deborah Charych
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Interactions of G_M1 Ganglioside with Crude Rat Brain Neuronal Membranes

Journal of Neurochemistry, 1980
Abstract:The binding of GM1, ganglioside to crude preparations of rat brain neuronal membranes was studied, the following results being obtained: (a) the binding process followed a biphasic kinetics, which displayed a break at 0.07–0.08 X 10−6m GM1, concentration; (b) the features of the binding process at GM1, concentrations below the break and, over ...
G. Toffano, D. Benvegnù, A. C. Bonetti, L. Facci, A. Leon, P. Orlando, R. Ghidoni, G. Tettamanti   +7 more
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Antibodies to ganglioside G_M1 induce mitogenic stimulation and cap formation in rat thymocytes

European Journal of Immunology, 1978
AbstractAntibodies towards the ganglioside GM1[galactosyl‐N‐acetylgalactosaminyl‐(N‐acetylneuraminyl)‐galactosylglucosyl ceramide] stimulated DNA synthesis in rat thymocytes. No mitogenic stimulation was observed with the monomeric Fab fragment of anti‐GM1, suggesting that cross‐linking of the gangliosides or associated components was required for ...
B A, Sela, A, Raz, B, Geiger
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G _M1 Ganglioside Treatment Facilitates Behavioral Recovery from Bilateral Brain Damage

Science, 1984
Adult rats with bilateral lesions of the caudate nucleus were treated with G M1 ganglioside. Although animals injected with a control solution were severely impaired in their ability to learn a complex spatial task, those treated with ganglioside were able to learn spatial reversals.
B A, Sabel, M D, Slavin, D G, Stein
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Fixation and Inactivation of Staphylococcal Leukocidin by Phosphatidylcholine and Ganglioside G _M1 in Rabbit Polymorphonuclear Leukocytes

Infection and Immunity, 1980
Staphylococcal leukocidin is resolved by chromatography on carboxymethyl cellulose columns into two components, which are designated F (fast) and S (slow). Fixation and inactivation of both components were studied as follows. (i) Leukocidin activity was confined to the first 10 min of intoxication, and the maximal effect resulted from ...
M, Noda, I, Kato, T, Hirayama, F, Matsuda   +3 more
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Biodistribution and Antitumor Effect of Adriamycin Encapsulated in Long-Circulating Liposomes Containing Amphipathic Polyethylene Glycol or Ganglioside G_M1

Journal of Liposome Research, 1994
AbstractBiodistribution and antitumor effect of adriamycin (ADM) encapsulated in liposomes with reduced uptake by reticuloendothelial system (RES) and prolonged circulation time were investigated in mice. Two different types of long-circulating liposomes, ganglioside GMI (GMl)/distearoyl phosphatidyl choline (DSPC) /cholesterol (CH) (0.13:1:1, m/m) and
Kazuo Maruyama, Aki Okamoto, Osamu Ishida, Shuji Kojima, Akinori Suginaka, Leaf Huang, Motohary Iwatsuru   +6 more
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G_M1 Ganglioside Treatment of PC 12 Cells Stimulates Ganglioside, Glycolipid, and Lipid, but Not Glycoprotein Synthesis Independently from the Effects of Nerve Growth Factor

Journal of Neurochemistry, 1986
Abstract: The incorporation of radioactive precursors into gangliosides and other glycolipids, glycoproteins, and total lipids has been studied in rat pheochromocytoma PC12 cells. Starting with the same PC12 cell pool, cultures displaying different degrees of neuritic expression in response to nerve growth factor (NGF) and combinations of serum ...
R, Katoh-Semba, S D, Skaper, S, Varon
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Characterization of the binding of cholera toxin to ganglioside G_M1 immobilized onto microtitre plates

Journal of Applied Toxicology, 2005
AbstractGanglioside GM1 is the receptor for cholera toxin on cell surfaces, and the binding of cholera toxin to GM1 immobilized on microtitre plates has been reported previously by several authors as an assay for the toxin (GM1‐ELISA). This assay has been examined in detail.
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