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Gangliosides in the 21st century: therapeutic prospects for the brain and spine [PDF]

Frontiers in Neurology
Gangliosides are sialylated glycosphingolipids highly enriched in the central nervous system, where they regulate membrane signaling, metabolism, neurogenesis, and immune responses.
Pierre J. Magistretti +7 more
doaj +4 more sources

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein [PDF]

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +2 more sources

Gangliosides in the Brain: Physiology, Pathophysiology and Therapeutic Applications

Frontiers in Neuroscience, 2020
Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane microdomains (“lipid rafts”) and play important roles in the modulation of ...
Danny Galleguillos, Simonetta Sipione, John Monyror +2 more
exaly +3 more sources

Gangliosides in Cutaneous Melanoma: Molecular Mechanisms, Translational Evidence Gaps, and Preclinical Natural-Compound Leads. [PDF]