Results 21 to 30 of about 20,173 (228)

Production of multiple brain-like ganglioside species is dispensable for fas-induced apoptosis of lymphoid cells. [PDF]

PLoS ONE, 2011
Activation of an acid sphingomyelinase (aSMase) leading to a biosynthesis of GD3 disialoganglioside has been associated with Fas-induced apoptosis of lymphoid cells. The present study was undertaken to clarify the role of this enzyme in the generation of
Iuliana Popa, Nicole Therville, Stéphane Carpentier, Thierry Levade, Olivier Cuvillier, Jacques Portoukalian   +5 more
doaj   +1 more source

Neuromuscular synaptic transmission in aged ganglioside-deficient mice [PDF]

, 2011
Gangliosides are sialylated glycosphingolipids that are present in high density on neuronal membranes, especially at synapses, where they are assumed to play functional or modulating roles.
Todorov, Boyan, Furukawa, Keiko, Furukawa, K., Plomp, J.J., Verschuuren, Jan J., Willison, H.J., Furukawa, Koichi, Plomp, Jaap J., Jacobs, B.C., Todorov, B., Willison, Hugh J., Jacobs, Bart C., Zitman, F.M.P., Verschuuren, J.J., Zitman, Femke M.P.   +14 more
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TNF differentially regulates ganglioside biosynthesis and expression in breast cancer cell lines. [PDF]

PLoS ONE, 2018
Gangliosides are glycosphingolipids concentrated in glycolipid-enriched membrane microdomains. Mainly restricted to the nervous system in healthy adult, complex gangliosides such as GD3 and GD2 have been shown to be involved in aggressiveness and ...
Justine H Dewald, Sumeyye Cavdarli, Agata Steenackers, Clément P Delannoy, Marlène Mortuaire, Corentin Spriet, Maxence Noël, Sophie Groux-Degroote, Philippe Delannoy   +8 more
doaj   +1 more source

LC-MS analysis of gangliosides : methods development and software solutions [PDF]

, 2023
Gangliosides are high molecular weight, specialized metabolites found at greatest concentration in the central nervous system. They are glycosphingolipids, possessing a nonpolar ceramide tail and a polar carbohydrate or ‘glycan’ head.
Smith, Ryan A., NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Diet-Induced Changes in Spectrum Patterns of Serum Gangliosides in 6-Month-Old Infants

Majalah Kedokteran Bandung, 2012
Human milk contains higher levels of gangliosides than infant formula. Gangliosides play a role in neuronal growth, migration and maturation, sinaptogenesis, and myelination.
Dida A. Gurnida, Ponpon Idjradinata, Deddy Muchtadi, Nanan Sekarwana, Bertram Fong, Paul McJarrow, Angela Rowan, Carmen Norris   +7 more
doaj   +1 more source

Specific synthesis of neurostatin and gangliosides O-acetylated in the outer sialic acids using a sialate transferase. [PDF]

PLoS ONE, 2012
Gangliosides are sialic acid containing glycosphingolipids, commonly found on the outer leaflet of the plasma membrane. O-acetylation of sialic acid hydroxyl groups is one of the most common modifications in gangliosides.
Lorenzo Romero-Ramírez, Isabel García-Álvarez, Ramón Campos-Olivas, Michel Gilbert, Marie-France Goneau, Alfonso Fernández-Mayoralas, Manuel Nieto-Sampedro   +6 more
doaj   +1 more source

Recovery of gangliosides from aqueous solutions on styrene-divinylbenzene copolymer columns1

Journal of Lipid Research, 2002
An investigation was made using a styrene-divinylbenzene copolymer as a solid phase sorbent to recover gangliosides from aqueous solutions. A comparison with octadecyl-bonded (C18) silica gel showed that the general procedure used to purify gangliosides ...
Iuliana Popa, Cristina Vlad, Jacques Bodennec, Jacques Portoukalian   +3 more
doaj   +1 more source

Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals [PDF]

, 2011
Objectives:  Anti-ganglioside antibodies are present in approximately half of Guillain–Barré syndrome (GBS) patients. Recently, it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a
Susumu Kusunoki, Tio-Gillen, Anne P., Plomp, J.J., Kusunoki, Susumu, Tio-Gillen, A.P., Willison, H.J., Broos, Ludo A.M., Ueda, M., Mark L. Kuijf, Ludo A. M. Broos, Kuijf, Mark L., Jacobs, B.C., Greenshields, Kay N., Jacobs, Bart C., Zitman, F.M.P., Hugh J. Willison, Anne P. Tio-Gillen, Masami Ueda, Kuijf, M.L., Jaap J. Plomp, Kusunoki, S., Greenshields, K.N., Plomp, Jaap J., Femke M. P. Zitman, Broos, L.A.M., Kay N. Greenshields, Ken-ichi Kaida, Willison, Hugh J., Bart C. Jacobs, Kaida, Ken Ichi, Kaida, K.I., Ueda, Masami, Zitman, Femke M.P.   +32 more
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Characterization and quantitative determination of gangliosides and neutral glycosphingolipids in human liver.

Journal of Lipid Research, 1982
The neutral and acidic glycolipids from the liver of an 11-year-old male were quantitatively isolated and characterized. The total concentration of gangliosides was also determined in sampled from five other human livers.
O Nilsson, L Svennerholm
doaj   +1 more source

Anti-inflammatory role of GM1 and other gangliosides on microglia

Journal of Neuroinflammation, 2022
Background Gangliosides are glycosphingolipids highly enriched in the brain, with important roles in cell signaling, cell-to-cell communication, and immunomodulation.
Danny Galleguillos, Qian Wang, Noam Steinberg, Asifa Zaidi, Gaurav Shrivastava, Kamaldeep Dhami, Gour C. Daskhan, Edward N. Schmidt, Zoë Dworsky-Fried, Fabrizio Giuliani, Matthew Churchward, Christopher Power, Kathryn Todd, Anna Taylor, Matthew S. Macauley, Simonetta Sipione   +15 more
doaj   +1 more source