Results 21 to 30 of about 26,990 (219)

TNF differentially regulates ganglioside biosynthesis and expression in breast cancer cell lines. [PDF]

open access: yesPLoS ONE, 2018
Gangliosides are glycosphingolipids concentrated in glycolipid-enriched membrane microdomains. Mainly restricted to the nervous system in healthy adult, complex gangliosides such as GD3 and GD2 have been shown to be involved in aggressiveness and ...
Justine H Dewald   +8 more
doaj   +1 more source

Recovery of gangliosides from aqueous solutions on styrene-divinylbenzene copolymer columns1

open access: yesJournal of Lipid Research, 2002
An investigation was made using a styrene-divinylbenzene copolymer as a solid phase sorbent to recover gangliosides from aqueous solutions. A comparison with octadecyl-bonded (C18) silica gel showed that the general procedure used to purify gangliosides ...
Iuliana Popa   +3 more
doaj   +1 more source

Diet-Induced Changes in Spectrum Patterns of Serum Gangliosides in 6-Month-Old Infants

open access: yesMajalah Kedokteran Bandung, 2012
Human milk contains higher levels of gangliosides than infant formula. Gangliosides play a role in neuronal growth, migration and maturation, sinaptogenesis, and myelination.
Dida A. Gurnida   +7 more
doaj   +1 more source

Specific synthesis of neurostatin and gangliosides O-acetylated in the outer sialic acids using a sialate transferase. [PDF]

open access: yesPLoS ONE, 2012
Gangliosides are sialic acid containing glycosphingolipids, commonly found on the outer leaflet of the plasma membrane. O-acetylation of sialic acid hydroxyl groups is one of the most common modifications in gangliosides.
Lorenzo Romero-Ramírez   +6 more
doaj   +1 more source

Characterization and quantitative determination of gangliosides and neutral glycosphingolipids in human liver.

open access: yesJournal of Lipid Research, 1982
The neutral and acidic glycolipids from the liver of an 11-year-old male were quantitatively isolated and characterized. The total concentration of gangliosides was also determined in sampled from five other human livers.
O Nilsson, L Svennerholm
doaj   +1 more source

Comprehensive Profiling of Surface Gangliosides Extracted from Various Cell Lines by LC-MS/MS

open access: yesCells, 2019
Gangliosides act as a surface marker at the outer cellular membrane and play key roles in cancer cell invasion and metastasis. Despite the biological importance of gangliosides, they have been still poorly characterized due to the lack of effective ...
Jua Lee   +9 more
doaj   +1 more source

Anti-inflammatory role of GM1 and other gangliosides on microglia

open access: yesJournal of Neuroinflammation, 2022
Background Gangliosides are glycosphingolipids highly enriched in the brain, with important roles in cell signaling, cell-to-cell communication, and immunomodulation.
Danny Galleguillos   +15 more
doaj   +1 more source

Ganglioside Alters Phospholipase Trafficking, Inhibits NF-κB Assembly, and Protects Tight Junction Integrity

open access: yesFrontiers in Nutrition, 2021
Background and Aims: Dietary gangliosides are present in human milk and consumed in low amounts from organ meats. Clinical and animal studies indicate that dietary gangliosides attenuate signaling processes that are a hallmark of inflammatory bowel ...
John J. Miklavcic   +7 more
doaj   +1 more source

Dysregulated Expression of Glycolipids in Tumor Cells: From Negative Modulator of Anti-Tumor Immunity to Promising Targets for Developing Therapeutic Agents

open access: yesFrontiers in Oncology, 2016
Glycolipids are complex molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the gangliosides, which are sialylated glycolipids ubiquitously distributed on the outer layer of ...
Jose Luis Daniotti   +2 more
doaj   +1 more source

Gangliosides and Neuroblastomas [PDF]

open access: yesInternational Journal of Molecular Sciences, 2020
The focus of this review is the ganglio-series of glycosphingolipids found in neuroblastoma (NB) and the myriad of unanswered questions associated with their possible role(s) in this cancer. NB is one of the more common solid malignancies of children. Five-year survival for those diagnosed with low risk NB is 90–95%, while that for children with high ...
openaire   +2 more sources

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