Results 11 to 20 of about 20,173 (228)
Journal of Lipid Research, 1964 The results of recent studies on the complexities of gangliosides from brain, spleen, and erythrocyte stroma are described, and ganglioside nomenclature is discussed.
Lars Svennerholm
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Gangliosides in the Brain: Physiology, Pathophysiology and Therapeutic Applications
Frontiers in Neuroscience, 2020 Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane microdomains (“lipid rafts”) and play important roles in the modulation of ...
Simonetta Sipione +2 more
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Differential distribution of major brain gangliosides in the adult mouse central nervous system. [PDF]
PLoS ONE, 2013 Gangliosides - sialic acid-bearing glycolipids - are major cell surface determinants on neurons and axons. The same four closely related structures, GM1, GD1a, GD1b and GT1b, comprise the majority of total brain gangliosides in mammals and birds ...
Katarina Vajn +4 more
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Ganglioside and Non-ganglioside Mediated Host Responses to the Mouse Polyomavirus. [PDF]
PLoS Pathogens, 2015 Gangliosides serve as receptors for internalization and infection by members of the polyomavirus family. Specificity is determined by recognition of carbohydrate moieties on the ganglioside by the major viral capsid protein VP1.
John You +6 more
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Alkali-labile gangliosides [PDF]
, 2023 The structure and properties of a group of gangliosides modified by mild alkaline treatment are discussed. We will present the occurrence and the structure of gangliosides carrying the N-acetyneuraminic acid O-acetylated in position 9, the Neu5,9Ac(2 ...
Sandro Sonnino, Laura Mauri
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Frontiers in Cell and Developmental Biology, 2022 Phenotypic switching between contractile (differentiated state) and proliferative (dedifferentiated state) vascular smooth muscle cells (VSMCs) is a hallmark of vascular remodeling that contributes to atherosclerotic diseases.
Norihiko Sasaki +5 more
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Lipid rafts and human diseases: why we need to target gangliosides
FEBS Open Bio, 2023 Gangliosides are functional components of membrane lipid rafts that control critical functions in cell communication. Many pathologies involve raft gangliosides, which therefore represent an approach of choice for developing innovative therapeutic ...
Jacques Fantini
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Journal of Lipid Research, 1995 Gangliosides in normal serum are found only in lipoproteins and the relative content of the three major lipoprotein fractions is low density lipoprotein > high density lipoprotein > very low density lipoprotein (LDL > HDL > VLDL).
A Rebbaa, J Portoukalian
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Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]
, 2008 Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K. +12 more
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Total ganglioside ablation at mouse motor nerve terminals alters neurotransmitter release level [PDF]
, 2010 Neuronal membrane gangliosides, forming a large family of sialylated glycosphingolipids, have been hypothesized to play important roles in synaptic transmission.
Furukawa, K. +4 more
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