Results 11 to 20 of about 44,745 (260)
How Do Gangliosides Regulate RTKs Signaling?
Cells, 2013 Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains, where they interact with molecules of signal transduction pathways including ...
Philippe Delannoy +2 more
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Anti-inflammatory role of GM1 and other gangliosides on microglia
Journal of Neuroinflammation, 2022 Background Gangliosides are glycosphingolipids highly enriched in the brain, with important roles in cell signaling, cell-to-cell communication, and immunomodulation.
Danny Galleguillos +15 more
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Gangliosides in the Brain: Physiology, Pathophysiology and Therapeutic Applications
Frontiers in Neuroscience, 2020 Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane microdomains (“lipid rafts”) and play important roles in the modulation of ...
Simonetta Sipione +4 more
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Differential distribution of major brain gangliosides in the adult mouse central nervous system. [PDF]
PLoS ONE, 2013 Gangliosides - sialic acid-bearing glycolipids - are major cell surface determinants on neurons and axons. The same four closely related structures, GM1, GD1a, GD1b and GT1b, comprise the majority of total brain gangliosides in mammals and birds ...
Katarina Vajn +4 more
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Gangliosides as Signaling Regulators in Cancer
International Journal of Molecular Sciences, 2021 At the plasma membrane, gangliosides, a group of glycosphingolipids, are expressed along with glycosphingolipids, phospholipids, and cholesterol in so-called lipid rafts that interact with signaling receptors and related molecules.
Norihiko Sasaki, M. Toyoda, T. Ishiwata
semanticscholar +2 more sources
The Role of Gangliosides in Neurodevelopment
Nutrients, 2015 Gangliosides are important components of neuronal cell membranes and it is widely accepted that they play a critical role in neuronal and brain development.
Jian Guan +2 more
exaly +2 more sources
O-acetylated Gangliosides as Targets for Cancer Immunotherapy
Cells, 2020 O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities.
Sumeyye Cavdarli +2 more
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Gangliosides in the 21st century: therapeutic prospects for the brain and spine [PDF]
Frontiers in NeurologyGangliosides are sialylated glycosphingolipids highly enriched in the central nervous system, where they regulate membrane signaling, metabolism, neurogenesis, and immune responses.
Pierre J. Magistretti +7 more
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Journal of Lipid Research, 1964 The results of recent studies on the complexities of gangliosides from brain, spleen, and erythrocyte stroma are described, and ganglioside nomenclature is discussed.
Lars Svennerholm
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Molecular recognition of gangliosides and their potential for cancer immunotherapies
Frontiers in Immunology, 2014 Gangliosides are sialic acid-containing glycosphingolipids expressed on all vertebrate cells. They are primarily positioned in the plasma membrane, with the ceramide part anchored in the membrane and the glycan part exposed on the surface of the cell ...
Ute eKrengel, Paula A Bousquet
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