Results 1 to 10 of about 56,805 (280)

Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine [PDF]

Journal of Nutrition and Metabolism, 2012
Gangliosides are integral to the structure and function of cell membranes. Ganglioside composition of the intestinal brush border and apical surface of the colon influences numerous cell processes including microbial attachment, cell division ...
John Janez Miklavcic, Kareena Leanne Schnabl, Vera Christine Mazurak, Alan Bryan Robert Thomson, Michael Thomas Clandinin   +4 more
doaj   +3 more sources

Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11. [PDF]

PLoS ONE, 2010
BackgroundAnti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barré syndrome (GBS) patients and are probably induced by molecular mimicry.
C Wim Ang, Jeroen R Dijkstra, Marcel A de Klerk, Hubert Ph Endtz, Pieter A van Doorn, Bart C Jacobs, Suzan H M Jeurissen, Jaap A Wagenaar   +7 more
doaj   +3 more sources

Ganglioside-Lipid and Ganglioside-Protein Interactions Revealed by Coarse-Grained and Atomistic Molecular Dynamics Simulations [PDF]

Journal of Physical Chemistry B, 2017
Gangliosides are glycolipids in which an oligosaccharide headgroup containing one or more sialic acids is connected to a ceramide. Gangliosides reside in the outer leaflet of the plasma membrane and play a crucial role in various physiological processes ...
De Vries, Alex H., Gu, Ruo-Xu, Ingólfsson, Helgi I, Marrink, Siewert J.; id_orcid, De Vries, Alex H.; id_orcid, Marrink, Siewert J., Tieleman, D. Peter   +6 more
core   +2 more sources

Single-Molecule Discrimination of Multisialylated Ganglioside Oligosaccharides Using an Engineered Nanopore [PDF]

Research
The function of ganglioside oligosaccharides critically depends on the number, linkage, and spatial arrangement of sialic acid residues, yet direct discrimination of highly sialylated ganglioside oligosaccharides, particularly at the isomeric level ...
Guangda Yao, Boyang Ren, Daigui Zhu, Jianling Tan, Jingjing Hou, Yuan Ma, Zhengyu Hang, Zhuojia Xu, Zhaobing Gao, Tiehai Li, Bingqing Xia   +10 more
doaj   +2 more sources

Ganglioside Regulation of AMPA Receptor Trafficking

Journal of Neuroscience, 2014
Gangliosides are major cell-surface determinants on all vertebrate neurons. Human congenital disorders of ganglioside biosynthesis invariably result in intellectual disability and are often associated with intractable seizures. To probe the mechanisms of
Yoo, Seung-Wan, Cole, Robert N., Dawson, Ted M., Huganir, Richard L., Schnaar, Ronald L., Umanah, George K.E., Lagerlöf, Olof,, Dawson, Valina L., Motari, Mary G., Prendergast, Jillian   +9 more
core   +2 more sources

Ganglioside Biochemistry [PDF]

ISRN Biochemistry, 2012
Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence, and metabolism. Key functional, biochemical, and pathobiochemical aspects are
T. Kolter
openaire   +3 more sources

Increased serum levels of anti-ganglioside M1 auto-antibodies in autistic children: relation to the disease severity

Journal of Neuroinflammation, 2011
Background Autoimmunity to the central nervous system (CNS) may play a pathogenic role in a subgroup of patients with autism. This study aimed to investigate the frequency of serum anti-ganglioside M1 auto-antibodies, as indicators of the presence of ...
AL-ayadhi Laila Y, Mostafa Gehan A
doaj   +2 more sources

Ganglioside lipidomics of CNS myelination using direct infusion shotgun mass spectrometry

iScience, 2022
Summary: Gangliosides are present and concentrated in axons and implicated in axon-myelin interactions, but how ganglioside composition changes during myelin formation is not known.
Martina Arends, Melanie Weber, Cyrus Papan, Markus Damm, Michal A. Surma, Christopher Spiegel, Minou Djannatian, Shengrong Li, Lisa Connell, Ludger Johannes, Martina Schifferer, Christian Klose, Mikael Simons   +12 more
doaj   +1 more source

Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis

Journal of Lipid Research, 2023
GM1 gangliosidosis is a neurodegenerative disorder caused by mutations in the GLB1 gene, which encodes lysosomal β-galactosidase. The enzyme deficiency blocks GM1 ganglioside catabolism, leading to accumulation of GM1 ganglioside and asialo-GM1 ...
Maria L. Allende, Y. Terry Lee, Colleen Byrnes, Cuiling Li, Galina Tuymetova, Jenna Y. Bakir, Elena-Raluca Nicoli, Virginia K. James, Jennifer S. Brodbelt, Cynthia J. Tifft, Richard L. Proia   +10 more
doaj   +1 more source

More severe manifestations and poorer short-term prognosis of ganglioside-associated Guillain-Barré syndrome in Northeast China. [PDF]

PLoS ONE, 2014
Ganglioside as a neurotrophic drug has been hitherto widely used in China, although Guillain-Barré syndrome (GBS) following intravenous ganglioside treatment was reported in Europe several decades ago.
Xiujuan Wu, Wei Wu, Zhengzheng Wang, Donghui Shen, Wei Pan, Ying Wang, Limin Wu, Xiaokun Wu, Jiachun Feng, Kangding Liu, Jie Zhu, Hong-Liang Zhang   +11 more
doaj   +1 more source