Results 31 to 40 of about 56,805 (280)

Altered expression of genes involved in ganglioside biosynthesis in substantia nigra neurons in Parkinson’s disease

PLoS ONE, 2018
Reduced expression of GM1 and other major brain gangliosides GD1a, GD1b and GT1b have been reported in Parkinson’s disease (PD) brain. Mechanisms underlying these changes are unclear but may be due to a deficit in the ganglioside biosynthetic process ...
J. Schneider
semanticscholar   +1 more source

Neuraminidase-1 contributes significantly to the degradation of neuronal B-series gangliosides but not to the bypass of the catabolic block in Tay–Sachs mouse models

Molecular Genetics and Metabolism Reports, 2015
Tay–Sachs disease is a severe lysosomal storage disorder caused by mutations in the HEXA gene coding for α subunit of lysosomal β-Hexosaminidase A enzyme, which converts GM2 to GM3 ganglioside. HexA−/− mice, depleted of the β-Hexosaminidase A iso-enzyme,
Z.K. Timur, S. Akyildiz Demir, C. Marsching, R. Sandhoff, V. Seyrantepe   +4 more
doaj   +1 more source

Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy

Frontiers in Oncology, 2020
Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in normal tissues, making most subtypes unsuitable as targets for cancer therapy. However, the disialoganglioside GD2 subtype has limited expression in normal tissues but is
Bassel Nazha, Cengiz Inal, Taofeek K. Owonikoko   +2 more
doaj   +1 more source

Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene

FEBS Open Bio, 2023
Genetic disruption of glycosyltransferases has provided clear information on the roles of their reaction products in the body. Our group has studied the function of glycosphingolipids by genetic engineering of glycosyltransferases in cell culture and in ...
Koichi Furukawa, Kogo Takamiya, Yuhsuke Ohmi, Robiul H. Bhuiyan, Orie Tajima, Keiko Furukawa   +5 more
doaj   +1 more source

Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]

, 2008
Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K., Plomp, J.J., Willison, H.J., Willison, HJ, Verschuuren, JJ, Todorov, B, Furukawa, K, Jacobs, B.C., Zitman, FMP, Todorov, B., Zitman, F.M.P., Verschuuren, J.J., Plomp, JJ   +12 more
core   +1 more source

Ganglioside lipids accelerate α-synuclein amyloid formation

Biochimica et Biophysica Acta - Proteins and Proteomics, 2018
The deposition of α-synuclein fibrils is one hallmark of Parkinson's disease. Here, we investigate how ganglioside lipids, present in high amounts in neurons and exosomes, influence the aggregation kinetics of α-synuclein. Gangliosides, as well as, other
Ricardo Gaspar, Jon Pallbo, U. Weininger, S. Linse, E. Sparr   +4 more
semanticscholar   +1 more source

Guillain-Barré Syndrome-related campylobacter jejuni in Bangladesh: ganglioside mimicry and cross-reactive antibodies [PDF]

, 2012
BACKGROUND: <br/> Campylobacter jejuni is the predominant antecedent infection in Guillain-Barré syndrome (GBS). Molecular mimicry and cross-reactive immune responses to C.
Klaij, K, Talukder, K.A. (Kaisar), Tio-Gillen, Anne P., Endtz Hubert P., Gilbert Michel, Klaij, K., Jianjun Li (139837), Anne P. Tio-Gillen (139842), Talukder, K.A., Gilbert, Michel, Klaij, Kevin, Kaisar A Talukder, Gillen, Anne, Islam, Zhahirul, Tio-Gillen Anne P., Quazi D Mohammad, Talukder, KA, Talukder, Kaisar A., Gilbert, M., van Rijs, W., Jacobs, Bart C., Alex van Belkum (38419), Hugh J Willison, Islam, Z. (Zhahirul), van Rijs, Wouter, Kevin Klaij, Jacobs Bart C., Willison, H.J. (Hugh), Quazi D. Mohammad (139834), Li, J. (Jianjun), Klaij Kevin, Talukder Kaisar A., Willison, HJ, Mohammad, Quazi D., Gilbert, M. (Michel), Klaij, K. (Kevin), Jacobs, B.C. (Bart), Bart C. Jacobs (139863), Endtz, Hubert, Jianjun Li, Bart C Jacobs, Li, J., Willison, Hugh J., Willison Hugh J., Kevin Klaij (139835), Rijs, Wouter, Zhahirul Islam, Tio-Gillen, A.P., Willison, H.J., Michel Gilbert (60775), Endtz, H.P., van Belkum Alex, Jacobs, B.C., Endtz, Hubert P., Mohammad, QD, van Belkum, Alex, Hugh J. Willison (139850), Mohammad Quazi D., van Rijs Wouter, Hubert P. Endtz (139857), Li, JJ, Michel Gilbert, Kaisar A. Talukder (139846), Mohammad, Q.D., Wouter van Rijs, Mohammad, Q.D. (Quazi), Zhahirul Islam (139833), Belkum, Alex, Hubert P Endtz, Gilbert, M, Belkum, A.F. (Alex) van, Islam Zhahirul, Islam, Z, Islam, Z., Tio-Gillen, A.P. (Anne), Endtz, H.P. (Hubert), Anne P Tio-Gillen, Wouter van Rijs (139839), Rijs, W. (Wouter) van, van Belkum, A., Li, Jianjun, Li Jianjun, Alex van Belkum   +82 more
core   +1 more source

Emerging concepts of ganglioside metabolism

FEBS Letters, 2018
Gangliosides (GGs) are sialic acid‐containing glycosphingolipids (GSLs) and major membrane components enriched on cellular surfaces. Biosynthesis of mammalian GGs starts at the cytosolic leaflet of endoplasmic reticulum (ER) membranes with the formation ...
R. Sandhoff, K. Sandhoff
semanticscholar   +1 more source

O-acetylated Gangliosides as Targets for Cancer Immunotherapy

Cells, 2020
O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities.
Sumeyye Cavdarli, Philippe Delannoy, Sophie Groux-Degroote   +2 more
doaj   +1 more source

Biology of GD2 ganglioside: implications for cancer immunotherapy

Frontiers in Pharmacology, 2023
Part of the broader glycosphingolipid family, gangliosides are composed of a ceramide bound to a sialic acid-containing glycan chain, and locate at the plasma membrane.
Pierre Machy, Erwan Mortier, Stéphane Birklé   +2 more
doaj   +1 more source