Results 31 to 40 of about 38,073 (235)

PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease

Cellular Physiology and Biochemistry, 2014
Background: Gangliosides were found to be associated with Alzheimer's disease (AD). Here we addressed a potential function of γ-secretase (presenilin) dependent cleavage of the amyloid-precursor-protein (APP) in the regulation of ganglioside de novo
Marcus O.W. Grimm, Benjamin Hundsdörfer, Sven Grösgen, Janine Mett, Valerie C. Zimmer, Christoph P. Stahlmann, Viola J. Haupenthal, Tatjana L. Rothhaar, Johannes Lehmann, Andreas Pätzold, Eva G. Zinser, Heikki Tanila, Jie Shen, Ulrike Müller, Heike S. Grimm, Tobias Hartmann   +15 more
doaj   +1 more source

Ganglioside Biochemistry [PDF]

ISRN Biochemistry, 2012
Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence, and metabolism. Key functional, biochemical, and pathobiochemical aspects are
openaire   +2 more sources

Therapeutic effects of anti‐GM2 CAR‐T cells expressing IL‐7 and CCL19 for GM2‐positive solid cancer in xenograft model

Cancer Medicine, 2023
Background While chimeric antigen receptor (CAR)‐T cell therapy has demonstrated excellent efficacy in hematopoietic malignancies, its clinical application in solid cancers has yet to be achieved.
Takahiro Sasaki, Yukimi Sakoda, Keishi Adachi, Yoshihiro Tokunaga, Koji Tamada   +4 more
doaj   +1 more source

The gangliosides

Journal of Lipid Research, 1964
The results of recent studies on the complexities of gangliosides from brain, spleen, and erythrocyte stroma are described, and ganglioside nomenclature is discussed. A description of the chemistry and methods of estimation of component groups (sialic acids, hexosamine and hexoses, fatty acids, and sphingosine bases) is followed by an account of the ...
openaire   +3 more sources

Ganglioside and Non-ganglioside Mediated Host Responses to the Mouse Polyomavirus. [PDF]

, 2015
Gangliosides serve as receptors for internalization and infection by members of the polyomavirus family. Specificity is determined by recognition of carbohydrate moieties on the ganglioside by the major viral capsid protein VP1.
John You (815059), Steven Levery (815061), Velupillai, Palanivel, John You, Samantha D O'Hara, Sherry Castle, Robert L Garcea, O’Hara, Samantha D., Palanivel Velupillai (37494), Thomas Benjamin (37498), Samantha D. O’Hara (814933), Castle, Sherry, Palanivel Velupillai, Thomas Benjamin, Sherry Castle (815060), Benjamin, Thomas, Steven Levery, Robert L. Garcea (147283), Garcea, Robert L., Levery, Steven, You, John, You John, Velupillai Palanivel, Levery Steven, Castle Sherry, O’Hara Samantha D., Benjamin Thomas, Garcea Robert L.   +27 more
core   +2 more sources

Ganglioside composition of differentiated Caco-2 cells resembles human colostrum and neonatal rat intestine [PDF]

, 2009
Gangliosides are glycosphingolipids found in cell membranes and human milk with important roles in cell proliferation, differentiation, growth, adhesion, migration, signalling and apoptosis.
Field, Catherine J., Schnabl, Kareena L., Clandinin M. Thomas   +2 more
core   +1 more source

Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity?

Frontiers in Cell and Developmental Biology, 2019
Thy-1 is a small membrane glycoprotein and member of the immunoglobulin superfamily of cell adhesion molecules. It is abundantly expressed in many cell types including neurons and is anchored to the outer membrane leaflet via a glycosyl ...
Katarina Ilic, Benedikt Auer, Kristina Mlinac-Jerkovic, Rodrigo Herrera-Molina, Rodrigo Herrera-Molina   +4 more
doaj   +1 more source

Ganglioside-Functionalized Nanoparticles for Chimeric Antigen Receptor T‑Cell Activation at the Immunological Synapse

, 2022
Chimeric Antigen Receptor (CAR) T cell therapy has proven to be an effective strategy against hematological malignancies but persistence and activity against solid tumors must be further improved.
Menna Siddiqui (14008478), Wilson W. Wong (1566760), Suryaram Gummuluru (246362), Björn M. Reinhard (1270716), Han Zang (14008475)   +4 more
core   +1 more source

Ganglioside-Lipid and Ganglioside-Protein Interactions Revealed by Coarse-Grained and Atomistic Molecular Dynamics Simulations

, 2016
Gangliosides are glycolipids in which an oligosaccharide headgroup containing one or more sialic acids is connected to a ceramide. Gangliosides reside in the outer leaflet of the plasma membrane and play a crucial role in various physiological processes ...
Helgi I. Ingólfsson (1294428), Ruo-Xu Gu (1522450), Siewert J. Marrink (135518), Alex H. de Vries (226821), D. Peter Tieleman (369170)   +4 more
core   +1 more source

Gangliosides and the Treatment of Neurodegenerative Diseases: A Long Italian Tradition

Biomedicines, 2022
Gangliosides are glycosphingolipids which are particularly abundant in the plasma membrane of mammalian neurons. The knowledge of their presence in the human brain dates back to the end of 19th century, but their structure was determined much later, in ...
Maria Fazzari, Giulia Lunghi, Elena Chiricozzi, Laura Mauri, Sandro Sonnino   +4 more
doaj   +1 more source