Results 31 to 40 of about 9,249 (183)

Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy

Frontiers in Oncology, 2020
Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in normal tissues, making most subtypes unsuitable as targets for cancer therapy. However, the disialoganglioside GD2 subtype has limited expression in normal tissues but is
Bassel Nazha, Cengiz Inal, Taofeek K. Owonikoko   +2 more
doaj   +1 more source

Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene

FEBS Open Bio, 2023
Genetic disruption of glycosyltransferases has provided clear information on the roles of their reaction products in the body. Our group has studied the function of glycosphingolipids by genetic engineering of glycosyltransferases in cell culture and in ...
Koichi Furukawa, Kogo Takamiya, Yuhsuke Ohmi, Robiul H. Bhuiyan, Orie Tajima, Keiko Furukawa   +5 more
doaj   +1 more source

Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]

, 2008
Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K., Plomp, J.J., Willison, H.J., Willison, HJ, Verschuuren, JJ, Todorov, B, Furukawa, K, Jacobs, B.C., Zitman, FMP, Todorov, B., Zitman, F.M.P., Verschuuren, J.J., Plomp, JJ   +12 more
core   +1 more source

Specific radioactive labeling of terminal N-acetylgalactosamine of glycosphingolipids by the galactose oxidase–sodium borohydride method

Journal of Lipid Research, 1972
The galactose oxidase–sodium borohydride method was used to specifically label the terminal N-acetylgalactosamine of three glycosphingolipids, Gm2-ganglioside, asialo-Gm2-ganglioside, and globoside.
Yoshiyuki Suzuki, Kunihiko Suzuki
doaj   +1 more source

O-acetylated Gangliosides as Targets for Cancer Immunotherapy

Cells, 2020
O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities.
Sumeyye Cavdarli, Philippe Delannoy, Sophie Groux-Degroote   +2 more
doaj   +1 more source

Biology of GD2 ganglioside: implications for cancer immunotherapy

Frontiers in Pharmacology, 2023
Part of the broader glycosphingolipid family, gangliosides are composed of a ceramide bound to a sialic acid-containing glycan chain, and locate at the plasma membrane.
Pierre Machy, Erwan Mortier, Stéphane Birklé   +2 more
doaj   +1 more source

Guillain-Barré Syndrome-related campylobacter jejuni in Bangladesh: ganglioside mimicry and cross-reactive antibodies [PDF]

, 2012
BACKGROUND: <br/> Campylobacter jejuni is the predominant antecedent infection in Guillain-Barré syndrome (GBS). Molecular mimicry and cross-reactive immune responses to C.
Klaij, K, Talukder, K.A. (Kaisar), Tio-Gillen, Anne P., Endtz Hubert P., Gilbert Michel, Klaij, K., Jianjun Li (139837), Anne P. Tio-Gillen (139842), Talukder, K.A., Gilbert, Michel, Klaij, Kevin, Kaisar A Talukder, Gillen, Anne, Islam, Zhahirul, Tio-Gillen Anne P., Quazi D Mohammad, Talukder, KA, Talukder, Kaisar A., Gilbert, M., van Rijs, W., Jacobs, Bart C., Alex van Belkum (38419), Hugh J Willison, Islam, Z. (Zhahirul), van Rijs, Wouter, Kevin Klaij, Jacobs Bart C., Willison, H.J. (Hugh), Quazi D. Mohammad (139834), Li, J. (Jianjun), Klaij Kevin, Talukder Kaisar A., Willison, HJ, Mohammad, Quazi D., Gilbert, M. (Michel), Klaij, K. (Kevin), Jacobs, B.C. (Bart), Bart C. Jacobs (139863), Endtz, Hubert, Jianjun Li, Bart C Jacobs, Li, J., Willison, Hugh J., Willison Hugh J., Kevin Klaij (139835), Rijs, Wouter, Zhahirul Islam, Tio-Gillen, A.P., Willison, H.J., Michel Gilbert (60775), Endtz, H.P., van Belkum Alex, Jacobs, B.C., Endtz, Hubert P., Mohammad, QD, van Belkum, Alex, Hugh J. Willison (139850), Mohammad Quazi D., van Rijs Wouter, Hubert P. Endtz (139857), Li, JJ, Michel Gilbert, Kaisar A. Talukder (139846), Mohammad, Q.D., Wouter van Rijs, Mohammad, Q.D. (Quazi), Zhahirul Islam (139833), Belkum, Alex, Hubert P Endtz, Gilbert, M, Belkum, A.F. (Alex) van, Islam Zhahirul, Islam, Z, Islam, Z., Tio-Gillen, A.P. (Anne), Endtz, H.P. (Hubert), Anne P Tio-Gillen, Wouter van Rijs (139839), Rijs, W. (Wouter) van, van Belkum, A., Li, Jianjun, Li Jianjun, Alex van Belkum   +82 more
core   +3 more sources

Increased serum levels of anti-ganglioside M1 auto-antibodies in autistic children: relation to the disease severity

Journal of Neuroinflammation, 2011
Background Autoimmunity to the central nervous system (CNS) may play a pathogenic role in a subgroup of patients with autism. This study aimed to investigate the frequency of serum anti-ganglioside M1 auto-antibodies, as indicators of the presence of ...
AL-ayadhi Laila Y, Mostafa Gehan A
doaj   +1 more source

Gangliosides and Neuroblastomas [PDF]

International Journal of Molecular Sciences, 2020
The focus of this review is the ganglio-series of glycosphingolipids found in neuroblastoma (NB) and the myriad of unanswered questions associated with their possible role(s) in this cancer. NB is one of the more common solid malignancies of children. Five-year survival for those diagnosed with low risk NB is 90–95%, while that for children with high ...
openaire   +2 more sources

Dynamic transformation of a cell-sized liposome containing ganglioside [PDF]

, 2011
It is important to understand the physicochemical mechanisms that are responsible for the morphological changes in the cell membrane in presence of various stimuli such as osmotic pressure.
Takagi, Masahiro, Hamada, Tsutomu, Masamune Morita, Mun'delanji C Vestergaard, Yoda, Tsuyoshi, Shruti Dhingra, Tsuyoshi Yoda, Tsutomu Hamada, Dhingra, Shruti, Masahiro Takagi, Vestergaard, Mun’delanji C., Morita, Masamune   +11 more
core   +1 more source