Results 31 to 40 of about 27,823 (179)
Journal of Neuroinflammation, 2011 Background Autoimmunity to the central nervous system (CNS) may play a pathogenic role in a subgroup of patients with autism. This study aimed to investigate the frequency of serum anti-ganglioside M1 auto-antibodies, as indicators of the presence of ...
AL-ayadhi Laila Y, Mostafa Gehan A
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PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease
Cellular Physiology and Biochemistry, 2014 Background: Gangliosides were found to be associated with Alzheimer's disease (AD). Here we addressed a potential function of γ-secretase (presenilin) dependent cleavage of the amyloid-precursor-protein (APP) in the regulation of ganglioside de novo
Marcus O.W. Grimm +15 more
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Cancer Medicine, 2023 Background While chimeric antigen receptor (CAR)‐T cell therapy has demonstrated excellent efficacy in hematopoietic malignancies, its clinical application in solid cancers has yet to be achieved.
Takahiro Sasaki +4 more
doaj +1 more source
Regulation of ganglioside biosynthesis in the nervous system
Journal of Lipid Research, 2004 Ganglioside biosynthesis is strictly regulated by the activities of glycosyltransferases and is necessarily controlled at the levels of gene transcription and posttranslational modification.
Robert K. Yu +3 more
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Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine
Journal of Nutrition and Metabolism, 2012 Gangliosides are integral to the structure and function of cell membranes. Ganglioside composition of the intestinal brush border and apical surface of the colon influences numerous cell processes including microbial attachment, cell division ...
John Janez Miklavcic +4 more
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Frontiers in Cell and Developmental Biology, 2019 Thy-1 is a small membrane glycoprotein and member of the immunoglobulin superfamily of cell adhesion molecules. It is abundantly expressed in many cell types including neurons and is anchored to the outer membrane leaflet via a glycosyl ...
Katarina Ilic +4 more
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Gangliosides and the Treatment of Neurodegenerative Diseases: A Long Italian Tradition
Biomedicines, 2022 Gangliosides are glycosphingolipids which are particularly abundant in the plasma membrane of mammalian neurons. The knowledge of their presence in the human brain dates back to the end of 19th century, but their structure was determined much later, in ...
Maria Fazzari +4 more
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Journal of Lipid Research, 1964 The results of recent studies on the complexities of gangliosides from brain, spleen, and erythrocyte stroma are described, and ganglioside nomenclature is discussed. A description of the chemistry and methods of estimation of component groups (sialic acids, hexosamine and hexoses, fatty acids, and sphingosine bases) is followed by an account of the ...
openaire +3 more sources
Micromachines, 2021 We determined the properties of fusion between large unilamellar vesicles (LUVs) and the lipid monolayer by measuring the fluorescence intensity of rhodamine-conjugated phospholipids in cell-sized lipid vesicles.
Koki Kamiya +2 more
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Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source