Results 21 to 30 of about 27,823 (179)
Structural basis of tetanus toxin neutralization by native human monoclonal antibodies
Cell Reports, 2021 Summary: Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 mg to 6 mg each that are equivalent to 250 IU of human anti-TeNT ...
Yueming Wang +18 more
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The Key Role of GM1 Ganglioside in Parkinson’s Disease
Biomolecules, 2022 We have endeavored in this review to summarize our findings, which point to a systemic deficiency of ganglioside GM1 in Parkinson’s disease (PD) tissues.
Suman Chowdhury, Robert Ledeen
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Ganglioside Biochemistry [PDF]
ISRN Biochemistry, 2012 Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence, and metabolism. Key functional, biochemical, and pathobiochemical aspects are
openaire +2 more sources
Bioactive Functions of Lipids in the Milk Fat Globule Membrane: A Comprehensive Review
Foods, 2023 The milk fat globule membrane (MFGM) is a complex tri-layer membrane that wraps droplets of lipids in milk. In recent years, it has attracted widespread attention due to its excellent bioactive functions and nutritional value.
Junyu Pan +7 more
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Molecular Genetics and Metabolism Reports, 2015 Tay–Sachs disease is a severe lysosomal storage disorder caused by mutations in the HEXA gene coding for α subunit of lysosomal β-Hexosaminidase A enzyme, which converts GM2 to GM3 ganglioside. HexA−/− mice, depleted of the β-Hexosaminidase A iso-enzyme,
Z.K. Timur +4 more
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Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy
Frontiers in Oncology, 2020 Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in normal tissues, making most subtypes unsuitable as targets for cancer therapy. However, the disialoganglioside GD2 subtype has limited expression in normal tissues but is
Bassel Nazha +2 more
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Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene
FEBS Open Bio, 2023 Genetic disruption of glycosyltransferases has provided clear information on the roles of their reaction products in the body. Our group has studied the function of glycosphingolipids by genetic engineering of glycosyltransferases in cell culture and in ...
Koichi Furukawa +5 more
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Journal of Lipid Research, 1972 The galactose oxidase–sodium borohydride method was used to specifically label the terminal N-acetylgalactosamine of three glycosphingolipids, Gm2-ganglioside, asialo-Gm2-ganglioside, and globoside.
Yoshiyuki Suzuki, Kunihiko Suzuki
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O-acetylated Gangliosides as Targets for Cancer Immunotherapy
Cells, 2020 O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities.
Sumeyye Cavdarli +2 more
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Biology of GD2 ganglioside: implications for cancer immunotherapy
Frontiers in Pharmacology, 2023 Part of the broader glycosphingolipid family, gangliosides are composed of a ceramide bound to a sialic acid-containing glycan chain, and locate at the plasma membrane.
Pierre Machy +2 more
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