Results 21 to 30 of about 38,073 (235)
Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]
, 2008 Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K. +12 more
core +1 more source
Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy
Frontiers in Oncology, 2020 Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in normal tissues, making most subtypes unsuitable as targets for cancer therapy. However, the disialoganglioside GD2 subtype has limited expression in normal tissues but is
Bassel Nazha +2 more
doaj +1 more source
Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene
FEBS Open Bio, 2023 Genetic disruption of glycosyltransferases has provided clear information on the roles of their reaction products in the body. Our group has studied the function of glycosphingolipids by genetic engineering of glycosyltransferases in cell culture and in ...
Koichi Furukawa +5 more
doaj +1 more source
Molecular Genetics and Metabolism Reports, 2015 Tay–Sachs disease is a severe lysosomal storage disorder caused by mutations in the HEXA gene coding for α subunit of lysosomal β-Hexosaminidase A enzyme, which converts GM2 to GM3 ganglioside. HexA−/− mice, depleted of the β-Hexosaminidase A iso-enzyme,
Z.K. Timur +4 more
doaj +1 more source
Journal of Lipid Research, 1972 The galactose oxidase–sodium borohydride method was used to specifically label the terminal N-acetylgalactosamine of three glycosphingolipids, Gm2-ganglioside, asialo-Gm2-ganglioside, and globoside.
Yoshiyuki Suzuki, Kunihiko Suzuki
doaj +1 more source
O-acetylated Gangliosides as Targets for Cancer Immunotherapy
Cells, 2020 O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities.
Sumeyye Cavdarli +2 more
doaj +1 more source
Biology of GD2 ganglioside: implications for cancer immunotherapy
Frontiers in Pharmacology, 2023 Part of the broader glycosphingolipid family, gangliosides are composed of a ceramide bound to a sialic acid-containing glycan chain, and locate at the plasma membrane.
Pierre Machy +2 more
doaj +1 more source
Journal of Neuroinflammation, 2011 Background Autoimmunity to the central nervous system (CNS) may play a pathogenic role in a subgroup of patients with autism. This study aimed to investigate the frequency of serum anti-ganglioside M1 auto-antibodies, as indicators of the presence of ...
AL-ayadhi Laila Y, Mostafa Gehan A
doaj +1 more source
Gangliosides and Neuroblastomas [PDF]
International Journal of Molecular Sciences, 2020 The focus of this review is the ganglio-series of glycosphingolipids found in neuroblastoma (NB) and the myriad of unanswered questions associated with their possible role(s) in this cancer. NB is one of the more common solid malignancies of children. Five-year survival for those diagnosed with low risk NB is 90–95%, while that for children with high ...
openaire +2 more sources
Graph attention network‐driven single‐cell omics analysis reveals how B4GALNT1‐mediated glycosylation remodelling of the ferroptosis–pyroptosis network promotes drug resistance in hepatocellular carcinoma [PDF]
Clin Transl MedSummary: B4GALNT1‐driven ganglioside/raft remodelling links ferroptosis suppression with restricted caspase‐1/GSDMD signalling during sorafenib resistance. Note: Schematic summary of the proposed B4GALNT1–ganglioside–lipid‐raft axis linking ferroptosis protection, restricted caspase‐1/GSDMD‐associated membrane permeabilisation, and sorafenib resistance.
Bie L +6 more
europepmc +2 more sources