Results 21 to 30 of about 9,249 (183)

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis

Nature Communications, 2022
Progranulin-deficieny results in gangliosidosis due to reduced lysosomal lipids (BMP) required for ganglioside degradation. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD.
Sebastian Boland, Sharan Swarup, Yohannes A. Ambaw, Pedro C. Malia, Ruth C. Richards, Alexander W. Fischer, Shubham Singh, Geetika Aggarwal, Salvatore Spina, Alissa L. Nana, Lea T. Grinberg, William W. Seeley, Michal A. Surma, Christian Klose, Joao A. Paulo, Andrew D. Nguyen, J. Wade Harper, Tobias C. Walther, Robert V. Farese   +18 more
doaj   +1 more source

Structural basis of tetanus toxin neutralization by native human monoclonal antibodies

Cell Reports, 2021
Summary: Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 mg to 6 mg each that are equivalent to 250 IU of human anti-TeNT ...
Yueming Wang, Changwen Wu, Jinfang Yu, Shujian Lin, Tong Liu, Lipeng Zan, Nan Li, Po Hong, Xiaoli Wang, Zhenxing Jia, Jason Li, Yao Wang, Ming Zhang, Xiaohui Yuan, Chengming Li, Wenwen Xu, Weihong Zheng, Xinquan Wang, Hua-Xin Liao   +18 more
doaj   +1 more source

Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals [PDF]

, 2011
Objectives:  Anti-ganglioside antibodies are present in approximately half of Guillain–Barré syndrome (GBS) patients. Recently, it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a
Susumu Kusunoki, Tio-Gillen, Anne P., Plomp, J.J., Kusunoki, Susumu, Tio-Gillen, A.P., Willison, H.J., Broos, Ludo A.M., Ueda, M., Mark L. Kuijf, Ludo A. M. Broos, Kuijf, Mark L., Jacobs, B.C., Greenshields, Kay N., Jacobs, Bart C., Zitman, F.M.P., Hugh J. Willison, Anne P. Tio-Gillen, Masami Ueda, Kuijf, M.L., Jaap J. Plomp, Kusunoki, S., Greenshields, K.N., Plomp, Jaap J., Femke M. P. Zitman, Broos, L.A.M., Kay N. Greenshields, Ken-ichi Kaida, Willison, Hugh J., Bart C. Jacobs, Kaida, Ken Ichi, Kaida, K.I., Ueda, Masami, Zitman, Femke M.P.   +32 more
core   +1 more source

MALDI TIMS IMS Reveals Ganglioside Molecular Diversity within Murine S. aureus Soft Tissue Abscesses. [PDF]

, 2023
Gangliosides play important roles in innate and adaptive immunity. The high degree of structural heterogeneity results in significant variability in ganglioside expression patterns and greatly complicates linking structure and function.
Katherine N., Gibson-Corley, Katerina V., Djambazova, Richard M., Caprioli, Jeffrey M., Spraggins, Eric P., Skaar, Jeffrey A., Freiberg   +5 more
core   +2 more sources

Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons [PDF]

, 2014
This work was supported by the Medical Research Council, the Christopher and Dana Reeve Foundation, the John and Lucille van Geest Foundation, the Henry Smith Charity, the Commonwealth and Overseas scholarships, and the Hinduja Cambridge Trust.PNS axons ...
Cheah, Menghon, Dotti, Carlos G, Andrews, Melissa R., Andrews, Melissa Renee, Kappagantula, Sunil, Abad-Rodriguez, Jose', Abad-Rodriguez, José, Fawcett, James W   +7 more
core   +1 more source

The Key Role of GM1 Ganglioside in Parkinson’s Disease

Biomolecules, 2022
We have endeavored in this review to summarize our findings, which point to a systemic deficiency of ganglioside GM1 in Parkinson’s disease (PD) tissues.
Suman Chowdhury, Robert Ledeen
doaj   +1 more source

Neuromuscular synaptic transmission in aged ganglioside-deficient mice [PDF]

, 2011
Gangliosides are sialylated glycosphingolipids that are present in high density on neuronal membranes, especially at synapses, where they are assumed to play functional or modulating roles.
Todorov, Boyan, Furukawa, Keiko, Furukawa, K., Plomp, J.J., Verschuuren, Jan J., Willison, H.J., Furukawa, Koichi, Plomp, Jaap J., Jacobs, B.C., Todorov, B., Willison, Hugh J., Jacobs, Bart C., Zitman, F.M.P., Verschuuren, J.J., Zitman, Femke M.P.   +14 more
core   +1 more source

Bioactive Functions of Lipids in the Milk Fat Globule Membrane: A Comprehensive Review

Foods, 2023
The milk fat globule membrane (MFGM) is a complex tri-layer membrane that wraps droplets of lipids in milk. In recent years, it has attracted widespread attention due to its excellent bioactive functions and nutritional value.
Junyu Pan, Meiqing Chen, Ning Li, Rongwei Han, Yongxin Yang, Nan Zheng, Shengguo Zhao, Yangdong Zhang   +7 more
doaj   +1 more source

Ganglioside-Functionalized Nanoparticles for Chimeric Antigen Receptor T‑Cell Activation at the Immunological Synapse

, 2022
Chimeric Antigen Receptor (CAR) T cell therapy has proven to be an effective strategy against hematological malignancies but persistence and activity against solid tumors must be further improved.
Menna Siddiqui (14008478), Wilson W. Wong (1566760), Suryaram Gummuluru (246362), Björn M. Reinhard (1270716), Han Zang (14008475)   +4 more
core   +1 more source

Neuraminidase-1 contributes significantly to the degradation of neuronal B-series gangliosides but not to the bypass of the catabolic block in Tay–Sachs mouse models

Molecular Genetics and Metabolism Reports, 2015
Tay–Sachs disease is a severe lysosomal storage disorder caused by mutations in the HEXA gene coding for α subunit of lysosomal β-Hexosaminidase A enzyme, which converts GM2 to GM3 ganglioside. HexA−/− mice, depleted of the β-Hexosaminidase A iso-enzyme,
Z.K. Timur, S. Akyildiz Demir, C. Marsching, R. Sandhoff, V. Seyrantepe   +4 more
doaj   +1 more source