Predicting GD2 expression across cancer types by the integration of pathway topology and transcriptome data [PDF]
Frontiers in BioinformaticsBackgroundThe disialoganglioside GD2 is a key cancer therapy target due to its overexpression in several cancers and limited presence in normal tissues. However, experimental assessment is technically challenging and not routinely available. We developed
Arsenij Ustjanzew +16 more
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Ganglioside lipidomics of CNS myelination using direct infusion shotgun mass spectrometry
iScience, 2022 Summary: Gangliosides are present and concentrated in axons and implicated in axon-myelin interactions, but how ganglioside composition changes during myelin formation is not known.
Martina Arends +12 more
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Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis
Journal of Lipid Research, 2023 GM1 gangliosidosis is a neurodegenerative disorder caused by mutations in the GLB1 gene, which encodes lysosomal β-galactosidase. The enzyme deficiency blocks GM1 ganglioside catabolism, leading to accumulation of GM1 ganglioside and asialo-GM1 ...
Maria L. Allende +10 more
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More severe manifestations and poorer short-term prognosis of ganglioside-associated Guillain-Barré syndrome in Northeast China. [PDF]
PLoS ONE, 2014 Ganglioside as a neurotrophic drug has been hitherto widely used in China, although Guillain-Barré syndrome (GBS) following intravenous ganglioside treatment was reported in Europe several decades ago.
Xiujuan Wu +11 more
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Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11. [PDF]
PLoS ONE, 2010 BackgroundAnti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barré syndrome (GBS) patients and are probably induced by molecular mimicry.
C Wim Ang +7 more
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Simultaneous measurements of auto-immune and infectious disease specific antibodies using a high throughput multiplexing tool. [PDF]
PLoS ONE, 2012 Considering importance of ganglioside antibodies as biomarkers in various immune-mediated neuropathies and neurological disorders, we developed a high throughput multiplexing tool for the assessment of gangliosides-specific antibodies based on Biolpex ...
Atul Asati +2 more
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Middle East Current Psychiatry, 2022 Background Autism may be one of the pediatric autoimmune neuropsychiatric disorders, and several studies investigated the frequency of serum anti-ganglioside M1 autoantibodies in children with autism, as possible indicators of autoimmunity to the brain ...
Reham Mohammad Raafat Hamed +3 more
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Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping. [PDF]
PLoS ONE, 2012 Modified gangliosides may be overexpressed in certain types of cancer, thus, they are considered a valuable target in cancer immunotherapy. Structural knowledge of their interaction with antibodies is currently limited, due to the large size and high ...
Mark Agostino +2 more
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A Variant Guillain-Barré Syndrome with Anti-Ganglioside Complex Antibody [PDF]
Journal of Neurocritical Care, 2018 Background Recently, anti-ganglioside complex (GSC) antibodies were discovered among the various subtypes of Guillain-Barré syndrome. GSC is the novel glycoepitopes formed by two individual ganglioside molecules.
So-Young Huh +6 more
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Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis
Nature Communications, 2022 Progranulin-deficieny results in gangliosidosis due to reduced lysosomal lipids (BMP) required for ganglioside degradation. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD.
Sebastian Boland +18 more
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