Results 11 to 20 of about 56,805 (280)
Middle East Current Psychiatry, 2022 Background Autism may be one of the pediatric autoimmune neuropsychiatric disorders, and several studies investigated the frequency of serum anti-ganglioside M1 autoantibodies in children with autism, as possible indicators of autoimmunity to the brain ...
Reham Mohammad Raafat Hamed +3 more
doaj +1 more source
Simultaneous measurements of auto-immune and infectious disease specific antibodies using a high throughput multiplexing tool. [PDF]
PLoS ONE, 2012 Considering importance of ganglioside antibodies as biomarkers in various immune-mediated neuropathies and neurological disorders, we developed a high throughput multiplexing tool for the assessment of gangliosides-specific antibodies based on Biolpex ...
Atul Asati +2 more
doaj +1 more source
International Journal of Molecular Sciences, 2020 Many species of ganglioside GM1, differing for the sialic acid and ceramide content, have been characterized and their physico-chemical properties have been studied in detail since 1963.
E. Chiricozzi +5 more
semanticscholar +1 more source
Mechanism of Secondary Ganglioside and Lipid Accumulation in Lysosomal Disease
International Journal of Molecular Sciences, 2020 Gangliosidoses are caused by monogenic defects of a specific hydrolase or an ancillary sphingolipid activator protein essential for a specific step in the catabolism of gangliosides.
Bernadette Breiden, K. Sandhoff
semanticscholar +1 more source
Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping. [PDF]
PLoS ONE, 2012 Modified gangliosides may be overexpressed in certain types of cancer, thus, they are considered a valuable target in cancer immunotherapy. Structural knowledge of their interaction with antibodies is currently limited, due to the large size and high ...
Mark Agostino +2 more
doaj +1 more source
A Variant Guillain-Barré Syndrome with Anti-Ganglioside Complex Antibody [PDF]
Journal of Neurocritical Care, 2018 Background Recently, anti-ganglioside complex (GSC) antibodies were discovered among the various subtypes of Guillain-Barré syndrome. GSC is the novel glycoepitopes formed by two individual ganglioside molecules.
So-Young Huh +6 more
doaj +1 more source
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis
Nature Communications, 2022 Progranulin-deficieny results in gangliosidosis due to reduced lysosomal lipids (BMP) required for ganglioside degradation. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD.
Sebastian Boland +18 more
doaj +1 more source
Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals [PDF]
, 2011 Objectives: Anti-ganglioside antibodies are present in approximately half of Guillain–Barré syndrome (GBS) patients. Recently, it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a
Susumu Kusunoki +32 more
core +1 more source
Structural basis of tetanus toxin neutralization by native human monoclonal antibodies
Cell Reports, 2021 Summary: Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 mg to 6 mg each that are equivalent to 250 IU of human anti-TeNT ...
Yueming Wang +18 more
doaj +1 more source
Molecular Neurodegeneration, 2019 Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson’s disease (PD).
Mylene Huebecker +6 more
semanticscholar +1 more source