Results 41 to 50 of about 9,249 (183)

PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease

Cellular Physiology and Biochemistry, 2014
Background: Gangliosides were found to be associated with Alzheimer's disease (AD). Here we addressed a potential function of γ-secretase (presenilin) dependent cleavage of the amyloid-precursor-protein (APP) in the regulation of ganglioside de novo
Marcus O.W. Grimm, Benjamin Hundsdörfer, Sven Grösgen, Janine Mett, Valerie C. Zimmer, Christoph P. Stahlmann, Viola J. Haupenthal, Tatjana L. Rothhaar, Johannes Lehmann, Andreas Pätzold, Eva G. Zinser, Heikki Tanila, Jie Shen, Ulrike Müller, Heike S. Grimm, Tobias Hartmann   +15 more
doaj   +1 more source

Ganglioside Biochemistry [PDF]

ISRN Biochemistry, 2012
Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence, and metabolism. Key functional, biochemical, and pathobiochemical aspects are
openaire   +2 more sources

Sialylation of campylobacter jejuni lipo-oligosaccharides: impact on phagocytosis and cytokine production in mice [PDF]

, 2012
<p>Background: Guillain-Barré syndrome (GBS) is a post-infectious polyradiculoneuropathy, frequently associated with antecedent Campylobacter jejuni (C. jejuni) infection. The presence of sialic acid on C.
Alistair S. Easton (176369), Astrid Heikema (176373), Alistair S Easton, Jim Guthrie, Donachie Anne M., Easton, A.S. (Alistair), Anne M. Donachie (176370), Boon, Louis, Goodyear, C.S. (Carl), Ruth Huizinga, Jacobs, Bart C., Hugh J Willison, Easton, Alistair S., van Rijs, Wouter, Louis Boon, Easton, AS, Samsom, JN, Jacobs Bart C., Willison, H.J. (Hugh), Heikema, Astrid, Willison, HJ, Louis Boon (87167), Jacobs, B.C. (Bart), Carl S Goodyear, Bart C. Jacobs (139863), Astrid Heikema, Guthrie, J. (Jim), Bart C Jacobs, Heikema, A.P. (Astrid), Boon, L. (Louis), Willison, Hugh J., Willison Hugh J., Donachie, AM, Guthrie, J, Carl S. Goodyear (176375), Heikema Astrid, van Rijs, W, Guthrie, Jim, Huizinga Ruth, Rijs, Wouter, Donachie, A.M. (Anne), Goodyear Carl S., Easton, Alistair, Samsom, J.N. (Janneke), Huizinga, Ruth, Anne M Donachie, Samsom, Janneke, Samsom Janneke N., Jacobs, B.C., Janneke N. Samsom (176374), Guthrie Jim, Boon, L, Goodyear, CS, Hugh J. Willison (139850), van Rijs Wouter, Huizinga, R, Huizinga, R. (Ruth), Boon Louis, Easton Alistair S., Wouter van Rijs, Boon, L (Louis), Wouter van Rijs (139839), Samsom, Janneke N., Rijs, W. (Wouter) van, Donachie, Anne M., Janneke N Samsom, Heikema, A, Ruth Huizinga (176367), Jacobs, BC, Goodyear, Carl S., Jim Guthrie (176371)   +70 more
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Incorporation, remodeling and re-expression of exogenous gangliosides in human cancer cell lines in vitro and in vivo [PDF]

, 2004
2004-05Human neuroblastomas and gliomas express high levels of GD2 ganglioside. Mechanisms for the re-expression of GD2 after the incorporation of an exogenous precursor structure were analyzed using a human heterophilic monoclonal antibody (mAb ...
Nishio, Masashi, Furukawa, Koichi
core   +1 more source

Therapeutic effects of anti‐GM2 CAR‐T cells expressing IL‐7 and CCL19 for GM2‐positive solid cancer in xenograft model

Cancer Medicine, 2023
Background While chimeric antigen receptor (CAR)‐T cell therapy has demonstrated excellent efficacy in hematopoietic malignancies, its clinical application in solid cancers has yet to be achieved.
Takahiro Sasaki, Yukimi Sakoda, Keishi Adachi, Yoshihiro Tokunaga, Koji Tamada   +4 more
doaj   +1 more source

Regulation of ganglioside biosynthesis in the nervous system

Journal of Lipid Research, 2004
Ganglioside biosynthesis is strictly regulated by the activities of glycosyltransferases and is necessarily controlled at the levels of gene transcription and posttranslational modification.
Robert K. Yu, Erhard Bieberich, Tian Xia, Guichao Zeng   +3 more
doaj   +1 more source

The gangliosides

Journal of Lipid Research, 1964
The results of recent studies on the complexities of gangliosides from brain, spleen, and erythrocyte stroma are described, and ganglioside nomenclature is discussed. A description of the chemistry and methods of estimation of component groups (sialic acids, hexosamine and hexoses, fatty acids, and sphingosine bases) is followed by an account of the ...
openaire   +3 more sources

Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity?

Frontiers in Cell and Developmental Biology, 2019
Thy-1 is a small membrane glycoprotein and member of the immunoglobulin superfamily of cell adhesion molecules. It is abundantly expressed in many cell types including neurons and is anchored to the outer membrane leaflet via a glycosyl ...
Katarina Ilic, Benedikt Auer, Kristina Mlinac-Jerkovic, Rodrigo Herrera-Molina, Rodrigo Herrera-Molina   +4 more
doaj   +1 more source

Gangliosides and the Treatment of Neurodegenerative Diseases: A Long Italian Tradition

Biomedicines, 2022
Gangliosides are glycosphingolipids which are particularly abundant in the plasma membrane of mammalian neurons. The knowledge of their presence in the human brain dates back to the end of 19th century, but their structure was determined much later, in ...
Maria Fazzari, Giulia Lunghi, Elena Chiricozzi, Laura Mauri, Sandro Sonnino   +4 more
doaj   +1 more source

Ganglioside-Lipid and Ganglioside-Protein Interactions Revealed by Coarse-Grained and Atomistic Molecular Dynamics Simulations

, 2016
Gangliosides are glycolipids in which an oligosaccharide headgroup containing one or more sialic acids is connected to a ceramide. Gangliosides reside in the outer leaflet of the plasma membrane and play a crucial role in various physiological processes ...
Helgi I. Ingólfsson (1294428), Ruo-Xu Gu (1522450), Siewert J. Marrink (135518), Alex H. de Vries (226821), D. Peter Tieleman (369170)   +4 more
core   +1 more source