Results 51 to 60 of about 38,073 (235)

Comparisons of electrophysiological findings and functional deficits between the ganglioside+ and ganglioside− groups.

, 2014
A. Electrophysiological examinations on patients in the ganglioside+ group revealed impairment mainly to axons suggestive of acute motor axonal neuropathy (AMAN). In the non-ganglioside-associated group (ganglioside− group), 46 out of 77 patients (59.7%)
Wei Pan (701), Kangding Liu (523236), Zhengzheng Wang (607257), Jiachun Feng (607261), Wei Wu (27708), Xiujuan Wu (523234), Limin Wu (607259), Xiaokun Wu (607260), Ying Wang (11406), Hong-Liang Zhang (321103), Donghui Shen (607258), Jie Zhu (126574)   +11 more
core   +1 more source

Dietary gangliosides rescue GM3 synthase deficiency outcomes in mice accompanied by neurogenesis in the hippocampus

Frontiers in Neuroscience
Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides. GM3 synthase deficiency (GM3SD) causes an absence of GM3 and all downstream biosynthetic derivatives, including all the a-, b-, c-series gangliosides, commonly found ...
Jin-ichi Inokuchi, Jin-ichi Inokuchi, Shinji Go, Akemi Suzuki, Osamu Nakagawasai, Takayo Odaira-Satoh, Lucas Veillon, Takahiro Nitta, Paul McJarrow, Hirotaka Kanoh, Kei-ichiro Inamori, Koichi Tan-No, Michael Collett   +12 more
doaj   +1 more source

Cholesterol accelerates the binding of Alzheimer’s beta-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation.

Frontiers in Physiology, 2013
Age-related alterations of membrane lipids in brain cell membranes together with high blood cholesterol are considered as major risk factors for Alzheimer’s disease. Yet the molecular mechanisms by which these factors increase Alzheimer’s risk are mostly
Jacques eFantini, Nouara eYahi, Nicolas eGarmy   +2 more
doaj   +1 more source

Are There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling?

Molecules, 2023
Lipid membrane nanodomains or lipid rafts are 10–200 nm diameter size cholesterol- and sphingolipid-enriched domains of the plasma membrane, gathering many proteins with different roles.
Alejandro K. Samhan-Arias, Joana Poejo, Dorinda Marques-da-Silva, Oscar H. Martínez-Costa, Carlos Gutierrez-Merino   +4 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Ganglioside Formation

, 2021
Dr.
Andrew G. Lee, MD; Shangyi Fu
core  

Purification of gangliosides by liquid-liquid partition chromatography

Journal of Lipid Research, 2008
A liquid-liquid partition chromatographic technique was applied to separate amphiphilic glycolipids. A two-phase solvent system composed of n-butanol-t-butyl methyl ether-acetonitrile-water at a volume ratio of 3:1:1:5 was found to be suitable for ...
Tomohisa Kato, Kenichi Hatanaka
doaj   +1 more source

Inhibition of Ganglioside Synthesis Suppressed Liver Cancer Cell Proliferation through Targeting Kinetochore Metaphase Signaling

Metabolites, 2021
The incidence and mortality of liver cancer, mostly hepatocellular carcinoma (HCC), have increased during the last two decades, partly due to persistent inflammation in the lipid-rich microenvironment associated with lifestyle diseases, such as obesity ...
Ting Su, Xian-Yang Qin, Naoshi Dohmae, Feifei Wei, Yutaka Furutani, Soichi Kojima, Wenkui Yu   +6 more
doaj   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source