Results 51 to 60 of about 56,805 (280)

Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons

, 2014
This work was supported by the Medical Research Council, the Christopher and Dana Reeve Foundation, the John and Lucille van Geest Foundation, the Henry Smith Charity, the Commonwealth and Overseas scholarships, and the Hinduja Cambridge Trust.PNS axons ...
Cheah, Menghon, Dotti, Carlos G, Andrews, Melissa R., Andrews, Melissa Renee, Kappagantula, Sunil, Abad-Rodriguez, Jose', Abad-Rodriguez, José, Fawcett, James W   +7 more
core   +1 more source

Ganglioside GD2 in reception and transduction of cell death signal in tumor cells

BMC Cancer, 2014
Ganglioside GD2 is expressed on plasma membranes of various types of malignant cells. One of the most promising approaches for cancer immunotherapy is the treatment with monoclonal antibodies recognizing tumor-associated markers such as ganglioside GD2 ...
I. Doronin, P. A. Vishnyakova, I. Kholodenko, E. Ponomarev, D. Ryazantsev, I. Molotkovskaya, R. Kholodenko   +6 more
semanticscholar   +1 more source

Prevalence of Anti-Ganglioside Antibodies and Their Clinical Correlates with Guillain-Barré Syndrome in Korea: A Nationwide Multicenter Study

Journal of Clinical Neurology, 2014
Background and Purpose No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barré syndrome (GBS) in Korea.
Jong Kuk Kim, J. Bae, Dae-Seong Kim, S. Kusunoki, Jong Eun Kim, J. Kim, Young-Eun Park, Ki-Jong Park, Hyun-Seok Song, S. Kim, Jeong-Geun Lim, Nam-Hee Kim, B. Suh, Tai-Seung Nam, M. Park, Young-Chul Choi, E. Sohn, S. Na, S. Huh, O. Kwon, Su-Yun Lee, Sunghoon Lee, Sun-Young Oh, S. Jeong, T. Lee, Dong Uk Kim   +25 more
semanticscholar   +1 more source

Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity?

Frontiers in Cell and Developmental Biology, 2019
Thy-1 is a small membrane glycoprotein and member of the immunoglobulin superfamily of cell adhesion molecules. It is abundantly expressed in many cell types including neurons and is anchored to the outer membrane leaflet via a glycosyl ...
Katarina Ilic, Benedikt Auer, Kristina Mlinac-Jerkovic, Rodrigo Herrera-Molina, Rodrigo Herrera-Molina   +4 more
doaj   +1 more source

Gangliosides and the Treatment of Neurodegenerative Diseases: A Long Italian Tradition

Biomedicines, 2022
Gangliosides are glycosphingolipids which are particularly abundant in the plasma membrane of mammalian neurons. The knowledge of their presence in the human brain dates back to the end of 19th century, but their structure was determined much later, in ...
Maria Fazzari, Giulia Lunghi, Elena Chiricozzi, Laura Mauri, Sandro Sonnino   +4 more
doaj   +1 more source

Ganglioside-Lipid and Ganglioside-Protein Interactions Revealed by Coarse-Grained and Atomistic Molecular Dynamics Simulations

, 2016
Gangliosides are glycolipids in which an oligosaccharide headgroup containing one or more sialic acids is connected to a ceramide. Gangliosides reside in the outer leaflet of the plasma membrane and play a crucial role in various physiological processes ...
Helgi I. Ingólfsson (1294428), Ruo-Xu Gu (1522450), Siewert J. Marrink (135518), Alex H. de Vries (226821), D. Peter Tieleman (369170)   +4 more
core   +1 more source

Ganglioside GD3 Is Required for Neurogenesis and Long-Term Maintenance of Neural Stem Cells in the Postnatal Mouse Brain

Journal of Neuroscience, 2014
The maintenance of a neural stem cell (NSC) population in mammalian postnatal and adult life is crucial for continuous neurogenesis and neural repair. However, the molecular mechanism of how NSC populations are maintained remains unclear.
Jing Wang, Allison Cheng, C. Wakade, R. Yu   +3 more
semanticscholar   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

CTBPro: A Next‐Generation Cholera Toxin Subunit B‐Based Neuroanatomical Tracer With Superior Brightness, Stability, and Sensitivity for Enhanced Neural Circuit Mapping

Advanced Science, EarlyView.
CTBPro is a next‐generation cholera toxin B–based tracer engineered by fusing CTB to the ultra‐stable fluorescent protein mBaojin. Exhibiting markedly enhanced molar brightness, CTBPro enables high‐fidelity neuronal labeling across multiple administration routes.
Xinghua Quan, Yude Lou, Huiqi Xie, Yifei Wang, Yanzhe Zhang, Yiran Ge, Linhe Yang, Xiaoxuan Zhang, Qingmiao Zhou, Huaizong Shen, Longxing Cao, Xin Jin, Jie‐Min Jia   +12 more
wiley   +1 more source

A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II.

Journal of Biological Chemistry, 1982
Two monoclonal antibodies produced by hybridomas obtained from a mouse immunized with a colorectal carcinoma cell line bind specifically to human gastrointestinal cancer cells.
John L. MagnaniS, Bo Nilssong, Manfred BrockhausSV, David Zopfl, Zenon SteplewskiJI, Hilary Koprowskill, V. Ginsburg   +6 more
semanticscholar   +1 more source