Results 71 to 80 of about 56,805 (280)

Structural insights into Clostridium perfringens delta toxin pore formation [PDF]

, 2013
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
Claire E Naylor, Gibert, M., Popoff, Michel, Popoff, M.R., Motta, A., Michel R Popoff, Christos G Savva, Jessica Huyet (425370), Ajit K. Basak (425373), Michel R. Popoff, Huyet Jessica, Naylor, Claire E., Basak Ajit K., Gibert, Maryse, Basak, Ajit,, Claire E. Naylor (425371), Ajit K. Basak, Savva Christos G., Michel R. Popoff (147963), Motta, Andrea, Claire E. Naylor, Basak, Ajit, K, Huyet, Jessica, Basak, Ajit K., Savva, Christos, G, Popoff Michel R., Naylor, Claire, E, Naylor Claire E., Ajit K Basak, Christos G. Savva (425372), Gibert Maryse, Naylor, Claire,, Savva, Christos,, Christos G. Savva, Maryse Gibert, Jessica Huyet, Maryse Gibert (269234), Savva, Christos G.   +37 more
core   +1 more source

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Cholesterol accelerates the binding of Alzheimer’s beta-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation.

Frontiers in Physiology, 2013
Age-related alterations of membrane lipids in brain cell membranes together with high blood cholesterol are considered as major risk factors for Alzheimer’s disease. Yet the molecular mechanisms by which these factors increase Alzheimer’s risk are mostly
Jacques eFantini, Nouara eYahi, Nicolas eGarmy   +2 more
doaj   +1 more source

Ganglioside composition of differentiated Caco-2 cells resembles human colostrum and neonatal rat intestine

, 2009
Gangliosides are glycosphingolipids found in cell membranes and human milk with important roles in cell proliferation, differentiation, growth, adhesion, migration, signalling and apoptosis.
Field, Catherine J., Schnabl, Kareena L., Clandinin M. Thomas   +2 more
core   +1 more source

Rare‐Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich, Sitki Cem Parlar, Cloe Chantereault, Lang Liu, Eric Yu, Uladzislau Rudakou, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Lior Greenbaum, Sharon Hassin‐Baer, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Roy N. Alcalay, Ziv Gan‐Or   +21 more
wiley   +1 more source

Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network

Journal of Cell Biology, 2005
Mutations in GDAP1 lead to severe forms of the peripheral motor and sensory neuropathy, Charcot-Marie-Tooth disease (CMT), which is characterized by heterogeneous phenotypes, including pronounced axonal damage and demyelination.
Axel Niemann, M. Ruegg, Veronica La Padula, A. Schenone, U. Suter   +4 more
semanticscholar   +1 more source

Purification of gangliosides by liquid-liquid partition chromatography

Journal of Lipid Research, 2008
A liquid-liquid partition chromatographic technique was applied to separate amphiphilic glycolipids. A two-phase solvent system composed of n-butanol-t-butyl methyl ether-acetonitrile-water at a volume ratio of 3:1:1:5 was found to be suitable for ...
Tomohisa Kato, Kenichi Hatanaka
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Comparisons of electrophysiological findings and functional deficits between the ganglioside+ and ganglioside− groups.

, 2014
A. Electrophysiological examinations on patients in the ganglioside+ group revealed impairment mainly to axons suggestive of acute motor axonal neuropathy (AMAN). In the non-ganglioside-associated group (ganglioside− group), 46 out of 77 patients (59.7%)
Wei Pan (701), Kangding Liu (523236), Zhengzheng Wang (607257), Jiachun Feng (607261), Wei Wu (27708), Xiujuan Wu (523234), Limin Wu (607259), Xiaokun Wu (607260), Ying Wang (11406), Hong-Liang Zhang (321103), Donghui Shen (607258), Jie Zhu (126574)   +11 more
core   +1 more source

Ganglioside and Non-ganglioside Mediated Host Responses to the Mouse Polyomavirus. [PDF]

, 2015
Gangliosides serve as receptors for internalization and infection by members of the polyomavirus family. Specificity is determined by recognition of carbohydrate moieties on the ganglioside by the major viral capsid protein VP1.
John You (815059), Steven Levery (815061), Velupillai, Palanivel, John You, Samantha D O'Hara, Sherry Castle, Robert L Garcea, O’Hara, Samantha D., Palanivel Velupillai (37494), Thomas Benjamin (37498), Samantha D. O’Hara (814933), Castle, Sherry, Palanivel Velupillai, Thomas Benjamin, Sherry Castle (815060), Benjamin, Thomas, Steven Levery, Robert L. Garcea (147283), Garcea, Robert L., Levery, Steven, You, John   +20 more
core   +1 more source