Results 81 to 90 of about 56,805 (280)

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes*

Journal of Biological Chemistry, 2012
Background: Ceramide synthase 1 catalyzes the synthesis of C18 ceramide and is mainly expressed in neurons of the brain. Results: Ablation of ceramide synthase 1 decreases ganglioside levels and expression of oligodendrocytic myelin-associated ...
Christina Ginkel, D. Hartmann, Katharina vom Dorp, A. Zlomuzica, Hany Farwanah, M. Eckhardt, R. Sandhoff, Joachim Degen, M. Rabionet, E. Dere, P. Dörmann, K. Sandhoff, K. Willecke   +12 more
semanticscholar   +1 more source

Ganglioside Formation

, 2021
Dr.
Andrew G. Lee, MD; Shangyi Fu
core  

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 800-828, July/August 2026.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Botulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell Entry*

Journal of Biological Chemistry, 2012
Background: How botulinum neurotoxin serotype C (BoNT/C) enters neurons is unclear. Results: BoNT/C utilizes dual gangliosides as host cell receptors. Conclusion: BoNT/C accesses gangliosides on the plasma membrane.
A. Karalewitz, Z. Fu, M. R. Baldwin, Jung‐Ja P. Kim, J. Barbieri   +4 more
semanticscholar   +1 more source

Biology of the BKPyV: An Update

Viruses, 2017
The BK virus (BKPyV) is a member of the Polyomaviridae family first isolated in 1971. BKPyV causes frequent infections during childhood and establishes persistent infections with minimal clinical implications within renal tubular cells and the urothelium.
Francois Helle, Etienne Brochot, Lynda Handala, Elodie Martin, Sandrine Castelain, Catherine Francois, Gilles Duverlie   +6 more
doaj   +1 more source

Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 829-850, July/August 2026.
ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song, HyunJi Lee, Youngshik Choe, Hyeyoung Lee   +3 more
wiley   +1 more source

Amyloid Precursor Protein (APP) Mediated Regulation of Ganglioside Homeostasis Linking Alzheimer's Disease Pathology with Ganglioside Metabolism

PLoS ONE, 2012
Gangliosides are important players for controlling neuronal function and are directly involved in AD pathology. They are among the most potent stimulators of Aβ production, are enriched in amyloid plaques and bind amyloid beta (Aβ).
M. Grimm, Eva G. Zinser, Sven Grösgen, B. Hundsdörfer, T. Rothhaar, V. K. Burg, L. Kaestner, T. Bayer, P. Lipp, U. Müller, H. Grimm, T. Hartmann   +11 more
semanticscholar   +1 more source

Simultaneous Study of Cholesterol and GM1 Ganglioside by Specific Probes: Lipid Distribution during Maturation, Capacitation and the Acrosome Reaction [PDF]

, 2016
Lipid distribution has been extensively studied in the plasma membrane of the male gamete due to its relevant role in sperm physiology. However, there are controversial reports about their distribution.
Lancelotti, T. S., Funes, Abi Karenina, Monclus, Maria de Los Angeles, Simón, Layla Yamila, Boarelli, Paola Vanina, Cabrillana, María Eugenia, Fornes, Miguel Walter   +6 more
core   +1 more source

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle, Fabio Lolicato, Carmelo Tempra, Martina Pannuzzo, Michele F. M. Sciacca, Danilo Milardi, Carmelo La Rosa   +6 more
wiley   +1 more source