Results 101 to 110 of about 56,805 (280)
Advanced Science, Volume 13, Issue 33, 15 June 2026.The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang +16 more
wiley +1 more source
Toxins, 2020 Botulinum neurotoxins (BoNTs) can be used therapeutically to treat a wide range of neuromuscular and neurological conditions. A collection of natural BoNT variants exists which can be classified into serologically distinct serotypes (BoNT/B), and further
Jonathan R. Davies +2 more
doaj +1 more source
, 2004 The procedures for the preparation of radioactive and photoactivable ganglioside derivatives have been continuously developed from 1989, when for the first time the synthesis of photoactivable tritium labeled GM1 ganglioside was presented.
S. Prioni +5 more
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Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications
Analytical Science Advances, Volume 7, Issue 1, June 2026.ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
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THE ROLE OF THE GANGLIOSIDE LIPID MOIETY IN THE PROCESS OF GANGLIOSIDE-CELL INTERACTIONS
, 1992 The role of the ceramide moiety of gangliosides, together with the deriving aggregative properties of ganglioside in solution, in the process of ganglioside-cell interactions was studied.
R. BASSI, S. SONNINO
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Case Report: Recurrent Guillain–Barré Syndrome in a 56‐Year‐Old Male
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Recurrent Guillain–Barré syndrome (GBS) is an uncommon variant of immune‐mediated polyradiculoneuropathy. We report a 56‐year‐old male who had two distinct episodes of acute inflammatory demyelinating neuropathy within the span of 3 months. The first episode presented with an episode of ascending paralysis and areflexia, with nerve conduction ...
Farah Sadiq +8 more
wiley +1 more source
Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review.
Journal of Lipid Research, 2008 Gangliosides are expressed in the outer leaflet of the plasma membrane of the cells of all vertebrates and are particularly abundant in the nervous system. Ganglioside metabolism is closely associated with the pathology of Alzheimer's disease (AD).
semanticscholar +1 more source
DESIGN, SYNTHESIS, AND VALIDATION OF GANGLIOSIDE PROBES TO REVEAL GANGLIOSIDE-PROTEIN INTERACTOME
, 2023 Gangliosides are glycosphingolipids that contain one or more sialic acids residues. Gangliosides are present, primarily on cell surfaces of every cell and tissue type in mammals, but are most abundantly found in the brain.
Porter, Mitchell
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Isolation and characterization of ganglioside GM1b from normal human brain.
Journal of Lipid Research, 1987 A sialidase-susceptible monosialoganglioside was isolated from normal human brain by DEAE-Sephadex A-25 and Iatrobeads column chromatography. The yield of this ganglioside was about 6 mg per whole brain.
T Ariga, R K Yu
doaj +1 more source
Factors Mediating Lipopolysaccharide-Induced Ganglioside Expression in Murine Peritoneal Macrophages
, 1989 The ganglioside composition of endotoxin-responsive C3H/HeN murine peritoneal macrophages is known to undergo dramatic changes in vivo in response to intraperitoneal lipopolysaccharides (LPS), unlike endotoxin-hyporesponsive C3H/HeJ macrophages.
Herbert C Yohe +2 more
core +1 more source