Results 121 to 130 of about 56,805 (280)

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Different IVIG glycoforms affect in vitro inhibition of anti-ganglioside antibody-mediated complement deposition [PDF]

, 2014
Intravenous immunoglobulin (IVIG) is the first line treatment for Guillain–Barré syndrome and multifocal motor neuropathy, which are caused by anti-ganglioside antibody-mediated complement-dependent cytotoxicity.
Yamaguchi, Yoshiki, Yuki, Nobuhiro, Peter J Späth, Shahrizaila, Nortina, Nortina Shahrizaila (635406), Makoto Sudo (635402), Peter J. Späth (635403), Benjamin K. Ong (635405), Yoshiki Yamaguchi, Yoshiki Yamaguchi (132437), Kana Matsumoto-Morita (635404), Sudo, Makoto, Benjamin K Ong, Nobuhiro Yuki (60770), Nortina Shahrizaila, Peter J. Späth, Matsumoto-Morita, Kana, Späth, Peter Julius, Makoto Sudo, Ong, Benjamin K., Benjamin K. Ong, Nobuhiro Yuki, Kana Matsumoto-Morita   +22 more
core   +1 more source

On why cancer cells require a great amount of glucose

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu, Aoran Liu, Rui Shi, Long Xu, Zhenyu Huang, Ye Zhang, Ying Xu   +6 more
wiley   +1 more source

A Modular Design of a Cholera Toxin B Subunit‐Scaffolded Sub‐Virion Nanoparticle Vaccine Against West Nile Virus

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
A recombinant West Nile virus (WNV) subunit vaccine was developed by displaying ED3 on a CTB scaffold. The fusion protein formed soluble nanoparticles in E. coli, eliciting strong, balanced, and specific neutralizing antibodies without cross‐reactivity, offering a safe, scalable subunit vaccine platform.
Hyun Byun, Tae Hoon Kim, Jemin Sung, Jung‐Min Lee, Sang‐Mu Shim, Sin Hae Kang, Hanul Kang, Dah Hyun Moon, Seong Hyun Park, Doda Kim, Sung Jae Kim, Seunghoo Kim, Gyoonhee Han, Baik Lin Seong   +13 more
wiley   +1 more source

Unique Ganglioside Recognition Strategies for Clostridial Neurotoxins*

Journal of Biological Chemistry, 2011
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin are the causative agents of the paralytic diseases botulism and tetanus, respectively. The potency of the clostridial neurotoxins (CNTs) relies primarily on their highly specific binding to nerve ...
M. A. Benson, Z. Fu, Jung‐Ja P. Kim, M. R. Baldwin   +3 more
semanticscholar   +1 more source

Predicting GD2 expression across cancer types by the integration of pathway topology and transcriptome data

Frontiers in Bioinformatics
BackgroundThe disialoganglioside GD2 is a key cancer therapy target due to its overexpression in several cancers and limited presence in normal tissues. However, experimental assessment is technically challenging and not routinely available. We developed
Arsenij Ustjanzew, Arsenij Ustjanzew, Arsenij Ustjanzew, Federico Marini, Federico Marini, Federico Marini, Saskia Wagner, Arthur Wingerter, Roger Sandhoff, Jörg Faber, Jörg Faber, Jörg Faber, Claudia Paret, Claudia Paret, Claudia Paret, Claudia Paret, Claudia Paret   +16 more
doaj   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, Volume 293, Issue 11, Page 3187-3210, June 2026.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Precursor of H-type II histo-blood group antigen and subterminal sialic acids on gangliosides are significantly implicated in cell entry and infection by a porcine P[11] rotavirus

Emerging Microbes and Infections
Rotaviruses, non-enveloped viruses with a double-stranded RNA genome, are the leading etiological pathogen of acute gastroenteritis in young children and animals. The P[11] genotype of rotaviruses exhibits a tropism for neonates.
Miaomiao Yan, Ang Su, Denise Meyer, Gleyder Roman Sosa, Henrik Fritsch, Malte Pitters, Nicole Fischer, Georg Herrler, Paul Becher   +8 more
doaj   +1 more source

Establishment of various ganglioside-expressing cells.

, 2018
(A) Biosynthetic pathway of gangliosides and glycolsyltransferase cDNAs used to establish various ganglioside-expressing cells. (B) Flow cytometry of ganglioside expression on GM2-, GM1-, GD3-, and GD2-expressing transfectans.
Orie Tajima (48929), Mariko Kambe (6000296), Koichi Furukawa (30035), Keiko Furukawa (48923), Kazunori Hamamura (6000299), Rika Takeuchi (3046725), Yuhsuke Ohmi (6000293), Yuki Ohkawa (48926)   +7 more
core   +1 more source

A Next‐Generation ELISA for the Detection of Anti‐(Para)Nodal Antibodies in Autoimmune Nodopathy and COVID‐19 Vaccinated Individuals

Journal of the Peripheral Nervous System, Volume 31, Issue 2, June 2026.
ABSTRACT Background and Aims Autoimmune nodopathy (AN) is a subtype of antibody‐mediated inflammatory neuropathy targeting the node of Ranvier (NoR). Diagnosis requires detection of anti‐(para)nodal autoantibodies like contactin‐1 and neurofascin‐155 via ELISA or cell‐based assays, but protocols are inconsistent. Causes of node autoimmunity are unknown,
Luise Appeltshauser, Chiara Ruprecht, Julia Reusch, Juliane Mees, Helena Glenewinkel, Claudia Sommer, Manuel Krone, Isabell Wagenhäuser, Kathrin Doppler, Nils Petri   +9 more
wiley   +1 more source