Results 141 to 150 of about 5,197 (158)

Direct Evidence That Endogenous G _M1 Ganglioside Can Mediate Thymocyte Proliferation

Science, 1985
The B subunit of cholera toxin, which is multivalent and binds exclusively to a specific ganglioside, G M1 , was mitogenic for rat thymocytes. When exposed to the B subunit, the cells proliferated, as measured by 3 H-labeled thymidine incorporation.
S, Spiegel, P H, Fishman, R J, Weber
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Interaction of multiple sclerosis serum with liposomes containing ganglioside G_M1

Annals of Neurology, 1980
AbstractMultiple sclerosis serum contains a factor or factors capable of releasing sequestered [14C]glucose from liposomes containing GM1, the major ganglioside present in human central nervous system myelin. Although some control sera can also release large quantities of liposomal glucose, multiple sclerosis and control sera differ in the mechanism of
B R, Mullin, A J, Montanaro, J D, Reid, R N, Nishimura   +3 more
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Preparation and Specificity of 11 Monoclonal Antibodies to G_M1 Ganglioside

Journal of Neurochemistry, 1986
Abstract Eleven monoclonal antibodies to GM1 ganglioside were prepared from hybridoma clones obtained by fusion of spleen cells from mice immunized with GM1 with mouse myeloma cells. When the reactivities of these 11 monoclonal antibodies were determined by enzyme‐linked immunosorbent assay with six glycosphingolipids (GM1, GD1a, GD1b, GT1b, GM2, and ...
S P, Mahadik, H, Laev, M M, Rapport
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Interaction of G_M1 Ganglioside with Bovine Serum Albumin Formation and Isolation of Multiple Complexes

European Journal of Biochemistry, 1980
The binding of ganglioside GM1 to bovine Serum albumin has been studied by using absorption and fluorescence properties of the protein chromophores. Differences to the ultraviolet absorption spectrum and in fluorescence quenching, as well as a marked shift of the wavelength at the fluorescences maximum provide information about the binding of this ...
Maurizio TOMASI, L. Giorgio RODA, Clara AUSIELLO, Giuliano D'AGNOLO, Bruno VENERANDO, Riccardo GHIDONI, Sandro SONNINO, Guido TETTAMANTI   +7 more
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Inhibition effects of gangliosides GM1, GD1a and GT1b on base-catalyzed isomerization of prostaglandin A2

Colloids and Surfaces B: Biointerfaces, 2001
Micellar inhibition effect of gangliosides on a degradation of drug was investigated, where ganglioside G(M1) (GM1), G(D1a) (GD1a) and G(T1b) (GTlb) whose sialic acid residue is one, two and three, respectively, were used. The base-catalyzed isomerization of prostaglandin A(2) (PGA(2)) to prostaglandin B(2) (PGB(2)) was chosen as a model experiment ...
S, Yokoyama, T, Takeda, M, Abe
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Interaction of Cholera Toxin and Ganglioside GM1

1976
The exotoxin produced by Vibrio cholerae is rapidly and firmly bound to the outer membrane of mammalian cells. With simple in vitro and in vivo methods and very pure gangliosides and allied glycolipids we have demonstrated that the monosialosylganglioside GM1 is the natural receptor for the cholera toxin.
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Molecular Recognition and Colorimetric Detection of Cholera Toxin by Poly(diacetylene) Liposomes Incorporating G_m1 Ganglioside

Langmuir, 1997
Molecular recognition sites on cell membranes serve as the main communication channels between the inside of a cell and its surroundings. Upon receptor binding, celular messages such as ion channel opening or activation of enzymes are triggered. In this report, we demonstrate that artificial cell membranes made from conjugated lipid polymers (poly ...
John J. Pan, Deborah Charych
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G M1 -gangliosidosis in a cross-bred dog confirmed by detection of G M1 -ganglioside using electrospray ionisation-tandem mass spectrometry

Acta Neuropathologica, 2000
The post-mortem diagnosis of lysosomal storage diseases can be confounded by the unavailability of suitable material. Here we report the diagnosis of GM1-gangliosidosis in a cross-bred dog, from which only formalin-fixed brain was available, by a combination of electron microscopy and the detection of elevated levels of GM1-ganglioside within the ...
P, Whitfield, A W, Johnson, K A, Dunn, A J, Delauche, B G, Winchester, R J, Franklin   +5 more
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Ganglioside G_M1and Hydrophilic Polymers Increase Liposome Circulation Times by Inhibiting the Association of Blood Proteins

Journal of Liposome Research, 1992
AbstractSeveral agents have been shown to prolong the circulation lifetime of liposomes. These agents, such as ganglioside GM1 or phosphatidylethanolamine-derivatives of monomethoxypolyethyleneglycols, provide insight into the mechanism(s) by which liposomes are cleared from the circulation.
Arcadio Chonn, Pieter R. Cullis
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Interactions of G_M1 Ganglioside with Crude Rat Brain Neuronal Membranes

Journal of Neurochemistry, 1980
Abstract:The binding of GM1, ganglioside to crude preparations of rat brain neuronal membranes was studied, the following results being obtained: (a) the binding process followed a biphasic kinetics, which displayed a break at 0.07–0.08 X 10−6m GM1, concentration; (b) the features of the binding process at GM1, concentrations below the break and, over ...
G. Toffano, D. Benvegnù, A. C. Bonetti, L. Facci, A. Leon, P. Orlando, R. Ghidoni, G. Tettamanti   +7 more
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