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Ubiquitination of G-Protein-Coupled Receptors

2004
In this chapter we describe methods for detecting the ubiquitination state of G-protein-coupled receptors (GPCRs). This involves coexpression of a GPCR with an epitope-tagged ubiquitin construct in a heterologous expression system. Modification by ubiquitin of the GPCR resulting from agonist activation is detected by immunoprecipation and subsequent ...
Adriano, Marchese, Jeffrey L, Benovic
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G‐protein‐coupled receptors: an update

Acta Physiologica, 2007
Abstract The receptors that couple to G proteins (GPCR) and which span the cell membranes seven times (7‐TM receptors) were the focus of a symposium in Stockholm 2006. The ensemble of GPCR has now been mapped in several animal species. They remain a major focus of interest in drug development, and their diverse physiological and pathophysiological ...
B B, Fredholm, T, Hökfelt, G, Milligan
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G‐Protein–Coupled Receptor Deorphanizations

2005
G protein–coupled receptors (GPCRs) are major regulators of intercellular interactions. They initiate these actions by being activated by a wide variety of natural ligands. Historically, ligands were discovered first, but the advent of molecular biology reversed this trend.
Yumiko, Saito, Olivier, Civelli
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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor