Results 311 to 320 of about 536,609 (348)

G Protein‐Coupled Receptor Kinases

Journal of Neurochemistry, 1994
T, Haga, K, Haga, K, Kameyama
openaire   +2 more sources

G-protein coupled receptor kinases and their inhibitors

Expert Opinion on Therapeutic Patents, 2000
G-protein coupled receptors (GPCRs) are regulated by several processes. One is the phosphorylation by G-protein coupled receptor kinases (GRKs) linked to processes like receptor desensitisation, internalisation and downregulation. GRKs also seem to be involved in various processes such as opioid addiction and cardiovascular diseases.
openaire   +1 more source

G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration

Biochemical Society Transactions, 1996
S S, Ferguson, J, Zhang, L S, Barak, M G, Caron   +3 more
openaire   +2 more sources

Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ

Science, 2003
D. Lodowski, J. Pitcher, W. D. Capel, R. Lefkowitz, J. Tesmer   +4 more
semanticscholar   +1 more source

Targeting G protein-coupled receptor kinases (GRKs) to G protein-coupled receptors.

Current opinion in endocrine and metabolic research
G protein-coupled receptors (GPCRs) interact with three protein families following agonist binding: heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs) and arrestins. GRK-mediated phosphorylation of GPCRs promotes arrestin binding to uncouple the receptor from G protein, a process called desensitization, and for many GPCRs, arrestin ...
Sarah M, Sulon, Jeffrey L, Benovic
openaire   +1 more source

Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies.

Molecular Pharmacology, 2004
T. Tran, J. Friedman, Eyad A. Qunaibi, Faiza Baameur, Robert H. Moore, R. B. Clark   +5 more
semanticscholar   +1 more source

Lipid modifications of G-protein-coupled receptor kinases

Biochemical Society Transactions, 1996
J, Inglese, R T, Premont
openaire   +2 more sources

G-Protein–Coupled Receptor Kinase Interacting Protein-1 Is Required for Pulmonary Vascular Development

Circulation, 2009
Jinjiang Pang, Gloria S Pryhuber, Xiangbin Xu   +2 more
exaly  

Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca 2+ Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction

Circulation, 2012
Philip W Raake, Leif E Vinge, Henriette Brinks   +2 more
exaly  

Prodeath Signaling of G Protein–Coupled Receptor Kinase 2 in Cardiac Myocytes After Ischemic Stress Occurs Via Extracellular Signal–Regulated Kinase-Dependent Heat Shock Protein 90–Mediated Mitochondrial Targeting

Circulation Research, 2013
Mai Chen, Priscila Y Sato, J Kurt Chuprun   +2 more
exaly