Results 321 to 330 of about 396,098 (353)
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Biomarkers in Medicine, 2009
With increasing knowledge of the regulatory mechanisms of G-protein-coupled receptor signaling in heart physiology, many studies have focused on the role of this system in cardiovascular disease. In recent years, scientists have moved their attention from the receptors to their regulatory proteins: the G-protein-coupled receptor kinases.
IACCARINO, GUIDO, CAMPANILE, ALFONSO
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With increasing knowledge of the regulatory mechanisms of G-protein-coupled receptor signaling in heart physiology, many studies have focused on the role of this system in cardiovascular disease. In recent years, scientists have moved their attention from the receptors to their regulatory proteins: the G-protein-coupled receptor kinases.
IACCARINO, GUIDO, CAMPANILE, ALFONSO
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Regulation of G protein-coupled receptor kinase 2
2002Publisher Summary G protein-coupled receptor kinase 2 (GRK2) was originally termed a “β-adrenergic receptor kinase” (βARK) because it was purified as a kinase of the adrenergic β 2 receptor, and the adrenergic β 2 receptor was the only known substrate of GRK2. GRK2 is now known to phosphorylate different kinds of G protein-coupled receptors (GPCRs),
Hirofumi Tsuga +4 more
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Receptor Tyrosine Kinases are Signaling Intermediates of G Protein- Coupled Receptors
Current Pharmaceutical Design, 2004G protein-coupled receptors (GPCRs) can utilize receptor tyrosine kinases (RTKs) to mediate important cellular responses such as proliferation, differentiation and survival. Recent advances in the field suggest that GPCR-induced transactivation of RTKs might be important for diseases such as cancer and cardiac hypertrophy. Depending on the receptor and
Piiper A, Zeuzem S
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THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION
Annual Review of Pharmacology and Toxicology, 1998▪ Abstract G protein–coupled receptors (GPRs) play a key role in controlling hormonal regulation of numerous second-messenger pathways. However, following agonist activation, most GPRs rapidly lose their ability to respond to hormone. For many GPRs, this process, commonly referred to as desensitization, appears to be primarily mediated by two protein
Jeffrey L. Benovic, Jason G. Krupnick
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Transgenic Manipulation of Myocardial G Protein–Coupled Receptors and Receptor Kinases
Circulation Research, 1996The ability to maintain and manipulate mouse embryos in vitro, perfected over the last decade, has launched the expanding field of transgenic experimentation. With the successful insertion of foreign genes into the mouse genome, important transgenic models have emerged in several venues of biomedical research.
Carmelo A. Milano +2 more
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G Protein‐Coupled Receptor Kinases
Journal of Neurochemistry, 1994Kazuko Haga +2 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-vornhagen +2 more
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