Results 271 to 280 of about 37,687,396 (313)

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Retraction: G protein-coupled receptor kinase-2 is a novel regulator of collagen synthesis in adult human cardiac fibroblasts. [PDF]

J Biol Chem, 2015
europepmc   +1 more source

Kinase-dependent and kinase-independent functions of G-protein-coupled receptor kinase 2 (GRK2)

, 2012
openaire   +2 more sources

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An oral dsRNA delivery system based on chitosan induces G protein-coupled receptor kinase 2 gene silencing for Apolygus lucorum control.

Pesticide Biochemistry and Physiology, 2023
RNA interference (RNAi) is recognized as a new and environmentally friendly pest control strategy due to its high specificity. However, the RNAi efficiency is relatively low in many sucking insect pests, such as Apolygus lucorum.
Heng Qiao, Jing Zhao, Xiaofeng Wang, Liu-Bin Xiao, K. Zhu‐Salzman, Jiaxin Lei, De-Jin Xu, Guang-Chun Xu, Yong-An Tan, De-Jun Hao   +9 more
semanticscholar   +1 more source

Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca 2+ Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction [PDF]

Circulation, 2012
G-protein-coupled receptor kinase 2 (GRK2) is a primary regulator of β-adrenergic signaling in the heart. G-protein-coupled receptor kinase 2 ablation impedes heart failure development, but elucidation of the cellular mechanisms has not been achieved ...
Steven Houser, Philip Raake, Xiongwen Chen   +2 more
exaly   +2 more sources

G Protein–Coupled Receptor Kinase 2 [PDF]

Circulation Research, 2014
Heart failure (HF) causes a tremendous burden on the worldwide healthcare system, affecting >23 million people. There are many cardiovascular disorders that contribute to the development of HF and multiple risk factors that accelerate its occurrence, but regardless of its underlying cause, HF is characterized by a marked decrease in myocardial ...
Walter Koch, Michele Ciccarelli
exaly   +4 more sources

G-protein-coupled receptor kinases in cardiovascular conditions: focus on G-protein-coupled receptor kinase 2, a gain in translational medicine

Biomarkers in Medicine, 2009
With increasing knowledge of the regulatory mechanisms of G-protein-coupled receptor signaling in heart physiology, many studies have focused on the role of this system in cardiovascular disease. In recent years, scientists have moved their attention from the receptors to their regulatory proteins: the G-protein-coupled receptor kinases.
IACCARINO, GUIDO, CAMPANILE, ALFONSO
openaire   +4 more sources

Selective Regulation of Gq Signaling by G Protein-Coupled Receptor Kinase 2: Direct Interaction of Kinase N Terminus with Activated Gαq

Molecular Pharmacology, 2000
In this study, we investigated the regulation of different G protein-coupled receptor (GPCR)-stimulated signaling pathways by GPCR kinase 2 (GRK2). We used thyrotropin receptor, which is coupled to different G proteins, to investigate the regulation of ...
M. Sallese, S. Mariggiò, Etrusca D'Urbano, L. Iacovelli, A. de Blasi   +4 more
semanticscholar   +1 more source

Regulation of G protein-coupled receptor kinase 2

2002
Publisher Summary G protein-coupled receptor kinase 2 (GRK2) was originally termed a “β-adrenergic receptor kinase” (βARK) because it was purified as a kinase of the adrenergic β 2 receptor, and the adrenergic β 2 receptor was the only known substrate of GRK2. GRK2 is now known to phosphorylate different kinds of G protein-coupled receptors (GPCRs),
Tatsuya, Haga, Kazuko, Haga, Kimihiko, Kameyama, Hirofumi, Tsuga, Norihiro, Yoshida   +4 more
openaire   +2 more sources