Results 211 to 220 of about 5,910,464 (346)

G‐protein signalling mediates differential production of toxic secondary metabolites [PDF]

, 2000
Andrew G. Tag, Julie K. Hicks, Gulnara F. Garifullina, Charles Ake, T. D. Phillips, Marian N. Beremand, Nancy P. Keller   +6 more
openalex   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Structural basis for adhesion G protein-coupled receptor Gpr126 function [PDF]

, 2020
Araç, Demet, Cunningham, Rebecca L., Feldman, Ezra, Leon, Katherine, Li, Jingxian, Monk, Kelly R., Riback, Joshua A., Sosnick, Tobin R., Zhao, Minglei   +8 more
core   +2 more sources

Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders. [PDF]

J Psychiatr Brain Sci
Lee BH, Meyer CM, Speca DJ, Díaz E.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Studies on cultured mast cells that have responsiveness to G protein-coupled mast cell activators.

, 1996
Tohru Ogasawara, Makoto Murakami, Tamiko Suzuki-Nishimura, Masaatsu K. Uchida, Ichiro Kudo   +4 more
openalex   +1 more source

The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner [PDF]

, 2018
Sun‐Hee Hwang, Kevin A. White, Bandarigoda N. Somatilaka, John M. Shelton, James A. Richardson, Saikat Mukhopadhyay   +5 more
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Regulation of G protein-coupled receptor kinase 2 and its role in tumors. [PDF]

J Transl Med
Liu C, Yang L, Peng S, Jing J, Ma L.
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source