Results 241 to 250 of about 5,910,464 (346)

G-protein-coupled receptor diversity and evolution in the closest living relatives of metazoa. [PDF]

Elife
Garcia De Las Bayonas A, King N.
europepmc   +1 more source

Evolution of translational elongation factor (EF) sequences: reliability of global phylogenies inferred from EF-1 alpha(Tu) and EF-2(G) proteins.

, 1994
Roberta Creti, Elena Ceccarelli, Maurizio Bocchetta, Anna Maria Sanangelantoni, O. Tiboni, Peter Palm, Piero Cammarano   +6 more
openalex   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Mechanistic Insights into G Protein-Biased κ-Opioid Receptor Signaling Using Dual-Charged Naltrexamine Amides. [PDF]

J Med Chem
Doering NP, Puls K, Diceglie M, Meraner A, Hentsch A, Hongnak S, Wurzer A, Schmidhammer H, Spetea M, Nazare M, Wolber G.   +10 more
europepmc   +1 more source

Image 1_Integrated multi-omics analysis and machine learning identify G protein-coupled receptor-related signatures for diagnosis and clinical benefits in soft tissue sarcoma.jpeg

Duo Wang (1787634), Jihao Tu (8365032), Jianfeng Liu (122580), Yuting Piao (14118642), Yiming Zhao (348349), Ying Xiong (245379), Jianing Wang (465119), Xiaotian Zheng (6287762), Bin Liu (5899)   +8 more
openalex   +1 more source

Investigating G Protein-Coupled Receptor Endocytosis and Trafficking by TIR-FM

, 2011
Guillermo A. Yudowski, Mark von Zastrow
openalex   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Cyclized Peptide Inhibitors of the Small G Protein Cdc42 Mimic Binding of Effector Proteins. [PDF]

Biochemistry
Murphy NP, Tetley GJN, Revell J, Mott HR, Owen D.   +4 more
europepmc   +1 more source

The cDNA sequence of the α-subunit of the Chinese Hamster adenylate cyclase-stimulatory G-protein

, 1990
Luc Mercken, Vincent Moras, Bruno Tocqué, Jean-François Mayaux   +3 more
openalex   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source