Results 241 to 250 of about 5,912,842 (308)

Multi-faceted roles of β-arrestins in G protein-coupled receptor endocytosis. [PDF]

Nat Commun
Liu J, Xue L, Ravier MA, Eshak F, Acher FC, Goupil-Lamy A, Cimadevila M, Drube J, Hoffmann C, Inoue A, Trinquet E, Dupuis E, Prézeau L, Pin JP, Rondard P.   +14 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

G protein-coupled receptor digital twins for precision and personalized medicine. [PDF]

Comput Struct Biotechnol J
Boeringer T, Pardo M, Craig CJ, Maudsley S.   +3 more
europepmc   +1 more source

Designing allosteric modulators to change GPCR G protein subtype selectivity. [PDF]

Nature
Moore MN, Person KL, Robleto VL, Alwin AR, Krusemark CL, Foster N, Ray C, Inoue A, Jackson MR, Sheedlo MJ, Barak LS, Marron Fernandez de Velasco E, Olson SH, Slosky LM.   +13 more
europepmc   +1 more source

Modelling G protein-biased agonism using GLP-1 receptor C-terminal mutations. [PDF]

Mol Metab
Tran HD, Zuo Y, Wong C, Pollard A, Bloom S, Jones B.   +5 more
europepmc   +1 more source

Dissociation kinetics of G proteins from G protein-coupled receptors and effects of allosteric modulation. [PDF]

Proc Natl Acad Sci U S A
Wang J, Nguyen ATN, Adediwura VA, Lu CS, McNeill SM, Jörg M, Scammells PJ, Christopoulos A, May LT, Miao Y.   +9 more
europepmc   +1 more source

G Protein-Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers. [PDF]

MedComm (2020)
Khan IR, Khurshid S, Almawash S, Kumar R, Akil ASA, Bhat AA, Macha MA.   +6 more
europepmc   +1 more source

UDP-glucose Activation of a G-protein/Sucrose Synthase Signaling Supercomplex

Jia H, Lou F, Watkins J, Oliveira CC, Tate CG, Jones AM.   +5 more
europepmc   +1 more source