Results 281 to 290 of about 5,959,864 (346)

G Protein-Coupled Estrogen Receptor Regulates Mesenchymal Stem Cell Mechanotransduction and Differentiation. [PDF]

Cell Mol Bioeng
Wang H, Ben Menachem-Zidon O, Pandey A, Xiao Y, Deng N, Shi X, Ruiz A, Ye Y, Cai H.   +8 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

In silico assessment of neuromuscular blocking agents and fluoroquinolones as ligands of the Mas-related G protein-coupled receptor X2. [PDF]

Pharmacol Rep
Rybka H, Dziadowiec A, Kwitniewski M, Bulanda D, Kitel R, Porębski G.   +5 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis. [PDF]

PLoS Pathog
Heinen M, Rovenich H, Altegoer F.
europepmc   +1 more source

G protein regulation in rice seed biology

Meng Xiong, Huiying Zhang, Yuxin Huang, Yibo Li   +3 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Structures of G-protein coupled receptor HCAR3 in complex with selective agonists reveal the basis for ligand recognition and selectivity. [PDF]

PLoS Biol
Ye F, Zhang Z, Zhang B, Li X, Deng J, Miao Q, Ning P, Chi Y, Chen G, Wu Z, Wang Q, Xu L, Gong N, Cheng B, Ma Z, Qian C, Zhu L, Pan X, Du Y.   +18 more
europepmc   +1 more source