Results 291 to 300 of about 5,910,464 (346)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Mas-related G protein-coupled receptor type D deficiency promotes tubulointerstitial injury and fibrosis associated with proteinuria in male mice. [PDF]

Physiol Rep
Oliveira LBF, Iost AF, Ribeiro LRA, Vieira MAR, Verano-Braga T, Santos RAS, Peruchetti DB.   +6 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Rapid purification of brain protein complexes containing active and inactive forms of the G protein Gαo. [PDF]

PLoS One
Yadav S, Veliventi SS, Meena S, Koelle MR, Kumar S.   +4 more
europepmc   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Cell-based and isoform-selective G protein-coupled receptor kinase assays for comprehensive inhibitor evaluation. [PDF]

Commun Biol
Blum NK, Kiefer MC, Decker A, Klement L, Matthees ESF, Weitzel V, Nagel F, Joseph B, Drube J, Uehling D, Hoffmann C, Schulz S.   +11 more
europepmc   +1 more source

G protein-coupled receptors as novel therapeutic targets in non-small-cell lung cancer. [PDF]

Med Rev (2021)
Ma L, Zhang P, Sun JP.
europepmc   +1 more source

Fine-Tuning of the Neuropeptide Y1 G Protein-Coupled Receptor by the Tryptophan^6.48 "Toggle Switch". [PDF]

J Am Chem Soc
Voitel M, Pankonin M, Vogel A, Leitner K, Kaiser A, Huster D, Hildebrand PW, Smith AA.   +7 more
europepmc   +1 more source

The Drosophila G protein-coupled receptor, GulpR, is essential for lipid mobilization in response to nutrient-limitation. [PDF]

PLoS Genet
Barraza D, Ding X, Findley L, Wang Z, Jugder BE, Watnick PI.   +5 more
europepmc   +1 more source

Galectin-3 Mediated Endocytosis of the Orphan G-Protein-Coupled Receptor GPRC5A. [PDF]

Cells
Boucheham A, Franco JM, Bär S, MacDonald E, Zuttion S, Blagec L, Rinaldi B, Chicher J, Kuhn L, Hammann P, Wunder C, Johannes L, Rechreche H, Friant S.   +13 more
europepmc   +1 more source