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Trends in Pharmacological Sciences, 1999
Heterotrimeric G proteins couple membrane-bound heptahelical receptors to their cellular effector systems (ion channels or enzymes generating a second messenger). In current pharmacotherapy, the input to G protein-regulated signalling is typically manipulated by targeting the receptor with appropriate agonists or antagonists and, to a lesser extent, by
M, Freissmuth +3 more
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Heterotrimeric G proteins couple membrane-bound heptahelical receptors to their cellular effector systems (ion channels or enzymes generating a second messenger). In current pharmacotherapy, the input to G protein-regulated signalling is typically manipulated by targeting the receptor with appropriate agonists or antagonists and, to a lesser extent, by
M, Freissmuth +3 more
openaire +2 more sources
Heterotrimeric G protein activation by G-protein-coupled receptors
Nature Reviews Molecular Cell Biology, 2008Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit.
William M, Oldham, Heidi E, Hamm
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G-protein-independent signaling by G-protein-coupled receptors
Trends in Neurosciences, 2000Two classes of receptors transduce neurotransmitter signals: ionotropic receptors and heptahelical metabotropic receptors. Whereas the ionotropic receptors are structurally associated with a membrane channel, a mediating mechanism is necessary to functionally link metabotropic receptors with their respective effectors.
Heuss, C, Gerber, U
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G Protein-Coupled Receptors and G Proteins
1997G protein-coupled receptors (GPCRs) belong to a large class of membrane-spanning receptors. GPCRs function as antennae for external signals consisting of chemical ligands or photons (in the case of opsins). Once the external signal is received, it is transduced to a cytosolic G protein. Subsequently, the G protein itself becomes activated.
Paul H. J. Nederkoorn +2 more
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G Proteins and G Protein-Coupled Receptors
2002Cells live in a constantly changing milieu. The structure and biochemical nature of this environment is dynamic and in order for normal cellular function to proceed in a manner appropriate for the benefit of the organism, cells must be able to access this changing information.
Michael A. Shetzline, Marc G. Caron
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G Protein-Coupled Receptors and G Proteins
2000G protein-coupled receptors (GPCRs) form a large and functionally diverse superfamily of cell membrane receptors. Many signaling cascades use GPCRs to convert a large diversity of external and internal stimuli including photons, odorants, and ions as well as hormones and neurotransmitter agonists into intracellular responses.
Alfredo Ulloa-Aguirre, P. Michael Conn
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2020
Preface Expression and Purification of G Protein a Subunits in E. scherichia coli - M. Linder Purification of Recombinant G Protein a and bg Subunits from Sf9 Cells-T. Kozasa Expression and Functional Analysis of G Protein a Subunits in Mammalian Cells...-C. H.
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Preface Expression and Purification of G Protein a Subunits in E. scherichia coli - M. Linder Purification of Recombinant G Protein a and bg Subunits from Sf9 Cells-T. Kozasa Expression and Functional Analysis of G Protein a Subunits in Mammalian Cells...-C. H.
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G-proteins | G Protein Signaling Regulators
2021John H. Exton, Sarah C. Stainbrook
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The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly