Results 301 to 310 of about 5,545,878 (337)

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

Muratspahić E, Feldman D, Kim DE, Qu X, Bratovianu A, Rivera-Sánchez P, Dimitri F, Cao J, Cary BP, Belousoff MJ, Keov P, Chen Q, Ren Y, Fine J, Sappington I, Schlichthaerle T, Zhang JZ, Pillai A, Mihaljević L, Bauer M, Torres SV, Motmaen A, Lee GR, Tran L, Wang X, Goreshnik I, Vafeados DK, Svendsen JE, Hosseinzadeh P, Lindegaard N, Brandt M, Waltenspühl Y, Deibler K, Oostdyk L, Cao W, Anantharaman L, Stewart L, Halloran L, Spangler JB, Sexton PM, Roth BL, Krumm BE, Wootten D, Tate CG, Norn C, Baker D.   +45 more
europepmc   +1 more source

Quantitative approaches for studying G protein-coupled receptor signalling and pharmacology.

J Cell Sci
Pearce A, Redfern-Nichols T, Wills E, Rosa M, Manulak I, Sisk C, Huang X, Atakpa-Adaji P, Prole DL, Ladds G.   +9 more
europepmc   +1 more source

Cell polarity control by an unconventional G-protein complex in bacteria

Dinet C, Sebban-Kreuzer C, Byrne-Kodjabachian D, Lhospice S, Herrou J, Durbesson F, Vincentelli R, Michelot A, Mignot T.   +8 more
europepmc   +1 more source

G protein-coupled receptor 35 (GPR35) stimulation reduces osteoclast activity in primary human bone cells

Price ML, Wyatt RA, Crastin A, Jamaluddin A, Hardy RS, Frost M, Gorvin CM.   +6 more
europepmc   +1 more source

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G proteins

Trends in Biochemical Sciences, 1992
The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits.
J R, Hepler, A G, Gilman
openaire   +4 more sources

G Proteins and G Protein-Coupled Receptors [PDF]

, 2002
Cells live in a constantly changing milieu. The structure and biochemical nature of this environment is dynamic and in order for normal cellular function to proceed in a manner appropriate for the benefit of the organism, cells must be able to access this changing information.
Marc G. Caron, Michael A. Shetzline
openaire   +1 more source

Heterotrimeric G protein activation by G-protein-coupled receptors [PDF]

Nature Reviews Molecular Cell Biology, 2008
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit.
William M. Oldham, Heidi E. Hamm
openaire   +2 more sources

G Protein Pathways

Science, 2002
The heterotrimeric guanine nucleotide–binding proteins (G proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. The extracellular signals are received by members of a large superfamily of receptors with seven membrane-spanning regions that activate the G ...
Prahlad T. Ram, Susana R. Neves, Ravi Iyengar   +2 more
openaire   +3 more sources

The role of G protein conformation in receptor–G protein selectivity

Nature Chemical Biology, 2023
G protein-coupled receptors (GPCRs) selectively activate at least one of the four families of heterotrimeric G proteins, but the mechanism of coupling selectivity remains unclear. Structural studies emphasize structural complementarity of GPCRs and nucleotide-free G proteins, but selectivity is likely to be determined by transient intermediate-state ...
Wonjo Jang, Sumin Lu, Xin Xu, Guangyu Wu, Nevin A. Lambert   +4 more
openaire   +2 more sources