Results 311 to 320 of about 5,910,464 (346)
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Trends in Pharmacological Sciences, 1999
Heterotrimeric G proteins couple membrane-bound heptahelical receptors to their cellular effector systems (ion channels or enzymes generating a second messenger). In current pharmacotherapy, the input to G protein-regulated signalling is typically manipulated by targeting the receptor with appropriate agonists or antagonists and, to a lesser extent, by
M, Freissmuth +3 more
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Heterotrimeric G proteins couple membrane-bound heptahelical receptors to their cellular effector systems (ion channels or enzymes generating a second messenger). In current pharmacotherapy, the input to G protein-regulated signalling is typically manipulated by targeting the receptor with appropriate agonists or antagonists and, to a lesser extent, by
M, Freissmuth +3 more
openaire +2 more sources
Heterotrimeric G protein activation by G-protein-coupled receptors
Nature Reviews Molecular Cell Biology, 2008Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit.
William M, Oldham, Heidi E, Hamm
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Mechanisms, regulation and functions of the unfolded protein response
Nature Reviews Molecular Cell Biology, 2020Claudio Hetz +2 more
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Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
Nature Reviews Molecular Cell Biology, 2021Simon Alberti, Anthony A Hyman
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The mechanisms of integral membrane protein biogenesis
Nature Reviews Molecular Cell Biology, 2021Ramanujan Shankar Hegde, Robert J Keenan
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Derivatization with fatty acids in peptide and protein drug discovery
Nature Reviews Drug Discovery, 2022Peter Kurtzhals +2 more
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The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Nature Reviews Molecular Cell Biology, 2012Claudio Hetz
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Functions and mechanisms of non-histone protein acetylation
Nature Reviews Molecular Cell Biology, 2018Takeo Narita, Chunaram Choudhary
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Advances in protein structure prediction and design
Nature Reviews Molecular Cell Biology, 2019Brian Kuhlman, Philip Bradley
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The amyloid state and its association with protein misfolding diseases
Nature Reviews Molecular Cell Biology, 2014Tuomas P J Knowles +2 more
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