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Structure of G Protein–Coupled Receptors and G Proteins

Science's STKE, 2005
This Teaching Resource provides lecture notes and slides for a class covering the structure and function of G protein–coupled receptors and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with a discussion of the crystal structure of rhodopsin and G protein subunits and then proceeds to describe the ...
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Chicken Anti-Protein G for the Detection of Small Amounts of Protein G

Hybridoma, 1993
Streptococcal protein G, similar to staphylococcal protein A, is the Fc-binding proteins that seems best suited for affinity-purification of mouse, rat or human monoclonal antibodies. We have developed a sandwich-ELISA for monitoring of protein G leakage from such columns.
Anders Larsson, Tomas L. Lindahl
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Chimaeric protein A/protein G and protein G/alkaline phosphatase as reporter molecules

Journal of Immunological Methods, 1992
The IgG binding domains of staphylococcal protein A and streptococcal protein G were expressed as a chimaera using the pGEX vector which has been advocated because its fusion proteins tend to be soluble and easily isolated on immobilised glutathione. This chimaera was soluble and abundant (yield = 18 mg/l of bacterial culture) and was tested by double ...
Shuhua Sun, Andrew M. Lew
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Signaling by the G Class of G Proteins

Cellular Signalling, 1996
The G12 class of G proteins are defined by the alpha-subunits of mammalian G12 and G13. Biochemical and mutational characterization of G alpha 12/13 have identified several novel signaling pathways regulated by these alpha-subunits. Studies with the constitutively activated mutants of G alpha 12 and G alpha 13 have indicated that they stimulate ...
Jonathan M. Dermott, N. Dhanasekaran
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G Proteins In Signal Transduction

Annual Review of Pharmacology and Toxicology, 1990
The last five years have seen major advances in our understanding of the central and generalized role of G-proteins as transducers of receptor signals into effector responses as outlined in Scheme 1. Signal-transducing G pro­ teins, in contrast to other GTP-binding proteins, are heterotrimers formed of one GTP-binding (and hydrolyzing) a subunit, one ...
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Conditional Mutagenesis of G-Protein Coupled Receptors and G-Proteins

2007
The G-protein-coupled receptor signaling system, consisting of a huge variety of receptors as well as of many G-proteins and effectors, operates in every cell and is involved in many physiological and pathological processes. The versatility of this system and the involvement of specific components makes G-protein-coupled receptors and their signaling ...
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G Proteins

2012
Publisher Summary This chapter reviews the types of G protein that exist in the nervous system and the ways in which they regulate signal transduction and other pro­cesses essential for brain function. G proteins comprise several families of diverse cellular proteins that subserve an equally diverse array of cellular functions.
Eric J. Nestler, Venetia Zachariou, Ronald S. Duman   +2 more
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Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor

ChemBioChem, 2002
R. Stenkamp, D. Teller, K. Palczewski
semanticscholar   +1 more source

G proteins and G-protein-coupled receptors: structure, function and interactions

Current Opinion in Neurobiology, 1991
The G protein family continues to grow and at least 15 heterotrimeric G proteins have now been identified. This review deals with the nature of the functional domains of the members of the G-protein-coupled receptor family as well as the associated G proteins.
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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

Science, 1996
Yu Feng, C. Broder, P. Kennedy, E. Berger   +3 more
semanticscholar   +1 more source