Results 41 to 50 of about 4,356,393 (396)

Treatment Decision‐Making Roles and Preferences Among Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Decision‐making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and socioeconomically diverse group of AYAs and their parents.
Amanda M. Gutierrez, Jill O. Robinson, Wendy A. Allen‐Rhoades, Hadley S. Smith, Isabel Canfield, Rebecca L. Hsu, Sarah R. Scollon, Lauren R. Desrosiers‐Battu, Nicole M. Schneider, Frank Y. Lin, Donald Williams Parsons, Sharon E. Plon, Mary A. Majumder, Janet Malek, Amy L. McGuire   +14 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Dialectal variation in lexical borrowings in Dangme

Legon Journal of the Humanities, 2022
This paper investigated dialectal variation in lexical borrowings in Dangme, a language spoken in Southern Ghana. Dangme has seven dialects (Ada, Gbugblaa, Yilɔ Krobo, Manya Krobo, Nugo, Sɛ and Osudoku), but this study concerns lexical borrowings into ...
Raymond Teye Akrobettoe, Regina Oforiwah Caesar, Evershed Kwasi Amuzu   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optimisation and Control of Vehicle Suspension Using Linear Quadratic Gaussian Control

Journal of Mechanical Engineering, 2018
The paper deals with the optimal design and analysis of quarter car vehicle suspension system based on the theory of linear optimal control because Linear Quadratic Gaussian (LQG) offers the possibility to emphasize quantifiable issues like ride comfort ...
Likaj Rame, Shala Ahmet
doaj   +1 more source

Optimal Design of Steel Structures Using Innovative Black Widow Algorithm Hybridized with Greedy Sensitivity-Based Particle Swarm Optimization Technique [PDF]

Journal of Soft Computing in Civil Engineering
This paper presents a Greedy Sensitivity-based analysis implemented on the Particle Swarm Optimization search engine (GSPSO). The effectiveness of the method focuses mainly on providing an intelligent population to enter meta-heuristic algorithms.
Mohammad Reza Ghasemi, Abdolhamid Salarnia, Mehdi Ghasri   +2 more
doaj   +1 more source

An Improved Intrusion Detection Algorithm Based on GA and SVM

IEEE Access, 2018
In the era of big data, with the increasing number of audit data features, human-centered smart intrusion detection system performance is decreasing in training time and classification accuracy, and many support vector machine (SVM)-based intrusion ...
Peiying Tao, Zhe Sun, Zhixin Sun
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Optimal Propeller design for future HALE UAV [PDF]

Scientific Technical Review, 2019
The main roles of unmanned air vehicles (UAVs) include: observation, surveillance, transportation, remote sensing and various security tasks. Improved, augmented type of UAVs are high-altitude long-endurance (HALE) aircraft capable and designed, as their
Svorcan Jelena, Hasan Sakib Mohammad, Baltić Marija, Simonović Aleksandar   +3 more
doaj