Results 51 to 60 of about 670,184 (249)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Nature CommunicationsThe homocatenation of electron-deficient Group 13 metals to form metal-metal multiple bonds through covalent self-assembly remains extremely challenging. Herein we demonstrate the synthesis and characterizations of N-heterocyclic carbene (NHC)-stabilized digallyl digallenes (1a and 1b), which exhibit unsaturated Ga-Ga=Ga-Ga chains with trans-bent ...
Ning Zhang +7 more
openaire +2 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Optimized design of low inclination satellite orbit using interconnection of STK and MATLAB
Dianzi Jishu YingyongA design method of low inclination satellite orbit which aims at special latitude regions is proposed. Firstly, the character of low inclination satellite orbit is analyzed.
Zhao Wence, Shu Chuanhua, Wang Shengxi
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Image Denoising with Modified Grey Wolf Optimizer
Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2018 In this study, image denoising hasbeen realized with with the one of the recent Nature-Inspired optimizationalgorithms, Grey Wolf Optimizer(GWO). GWO is one of the recent most studiedcontinous optimization algorithm which performs better than the ...
Pakize Erdoğmuş, Hüseyin Avni Ardaç
doaj +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
A crucial phase in plants – it's a gas, gas, gas! [PDF]
New Phytologist, 2022 Steven Jansen +4 more
openaire +2 more sources
A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source