Results 51 to 60 of about 1,118,058 (284)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Gas vesicles [PDF]

open access: yesMicrobiological Reviews, 1975
The gas vesicle is a hollow structure made of protein. It usually has the form of a cylindrical tube closed by conical end caps. Gas vesicles occur in five phyla of the Bacteria and two groups of the Archaea, but they are mostly restricted to planktonic microorganisms, in which they provide buoyancy.
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Optimisation and Control of Vehicle Suspension Using Linear Quadratic Gaussian Control

open access: yesJournal of Mechanical Engineering, 2018
The paper deals with the optimal design and analysis of quarter car vehicle suspension system based on the theory of linear optimal control because Linear Quadratic Gaussian (LQG) offers the possibility to emphasize quantifiable issues like ride comfort ...
Likaj Rame, Shala Ahmet
doaj   +1 more source

Optimal Design of Steel Structures Using Innovative Black Widow Algorithm Hybridized with Greedy Sensitivity-Based Particle Swarm Optimization Technique [PDF]

open access: yesJournal of Soft Computing in Civil Engineering
This paper presents a Greedy Sensitivity-based analysis implemented on the Particle Swarm Optimization search engine (GSPSO). The effectiveness of the method focuses mainly on providing an intelligent population to enter meta-heuristic algorithms.
Mohammad Reza Ghasemi   +2 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Model Optimasi SVM Dengan PSO-GA dan SMOTE Dalam Menangani High Dimensional dan Imbalance Data Banjir

open access: yesTeknika
Banjir merupakan salah satu bencana alam yang sering terjadi di Indonesia, termasuk di Kota Samarinda dengan 18-33 titik desa terdampak dari tahun 2018-2021.
Raenald Syaputra   +2 more
doaj   +1 more source

Optimal Propeller design for future HALE UAV [PDF]

open access: yesScientific Technical Review, 2019
The main roles of unmanned air vehicles (UAVs) include: observation, surveillance, transportation, remote sensing and various security tasks. Improved, augmented type of UAVs are high-altitude long-endurance (HALE) aircraft capable and designed, as their
Svorcan Jelena   +3 more
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Towards Effective COVID-19 Sentiment Analysis Using Bio-Inspired Feature Optimization

open access: yesJournal of Communications Software and Systems
Analyzing sentiments in social media content related to COVID-19 presents major challenges, especially given the sheer volume of data and the complexity of text features.
Mohamed Debbab   +4 more
doaj   +1 more source

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