Results 41 to 50 of about 4,282,587 (297)

Using Serious Games for Learning British Sign Language Combining Video, Enhanced Interactivity, and VR Technology [PDF]

Journal of Universal Computer Science, 2020
One in every six persons in the UK suffers a hearing loss, either as a condition they have been born with, or they developed during their life. Nine hundred thousand people in the UK are severely or profoundly deaf.
Daphne Economou, Melissa Russi, Ioannis Doumanis, Markos Mentzelopoulos, Vassiliki Bouki, Jeffery Ferguson   +5 more
doaj   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Optimisation and Control of Vehicle Suspension Using Linear Quadratic Gaussian Control

Journal of Mechanical Engineering, 2018
The paper deals with the optimal design and analysis of quarter car vehicle suspension system based on the theory of linear optimal control because Linear Quadratic Gaussian (LQG) offers the possibility to emphasize quantifiable issues like ride comfort ...
Likaj Rame, Shala Ahmet
doaj   +1 more source

Optimal Design of Steel Structures Using Innovative Black Widow Algorithm Hybridized with Greedy Sensitivity-Based Particle Swarm Optimization Technique [PDF]

Journal of Soft Computing in Civil Engineering
This paper presents a Greedy Sensitivity-based analysis implemented on the Particle Swarm Optimization search engine (GSPSO). The effectiveness of the method focuses mainly on providing an intelligent population to enter meta-heuristic algorithms.
Mohammad Reza Ghasemi, Abdolhamid Salarnia, Mehdi Ghasri   +2 more
doaj   +1 more source

Dialectal variation in lexical borrowings in Dangme

Legon Journal of the Humanities, 2022
This paper investigated dialectal variation in lexical borrowings in Dangme, a language spoken in Southern Ghana. Dangme has seven dialects (Ada, Gbugblaa, Yilɔ Krobo, Manya Krobo, Nugo, Sɛ and Osudoku), but this study concerns lexical borrowings into ...
Raymond Teye Akrobettoe, Regina Oforiwah Caesar, Evershed Kwasi Amuzu   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Optimal Propeller design for future HALE UAV [PDF]

Scientific Technical Review, 2019
The main roles of unmanned air vehicles (UAVs) include: observation, surveillance, transportation, remote sensing and various security tasks. Improved, augmented type of UAVs are high-altitude long-endurance (HALE) aircraft capable and designed, as their
Svorcan Jelena, Hasan Sakib Mohammad, Baltić Marija, Simonović Aleksandar   +3 more
doaj