Results 41 to 50 of about 1,118,058 (284)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2018 A series of nanosized [Al]-, [Ga, Al]-, and [Ga]-HZSM-5 catalysts with a fixed Si-to-M3+ ratio (M = Al or Ga) was synthesized by a seed-induced crystallization method.
Yu-Chuan Lin (459680) +2 more
core +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Test Frequency Selection Using Particle Swarm Optimization
Advances in Electrical and Electronic Engineering, 2013 The paper deals with the problem of test frequency selection for multi-frequency parametric fault diagnosis of analog linear circuits. An appropriate set of test frequencies is determined by minimizing the conditionality of the sensitivity matrix based ...
Zdenek Kincl, Zdenek Kolka
doaj +1 more source
Using Serious Games for Learning British Sign Language Combining Video, Enhanced Interactivity, and VR Technology [PDF]
Journal of Universal Computer Science, 2020 One in every six persons in the UK suffers a hearing loss, either as a condition they have been born with, or they developed during their life. Nine hundred thousand people in the UK are severely or profoundly deaf.
Daphne Economou +5 more
doaj +3 more sources
GA-Fuzzy PID control simulation waveform diagram.
, 2023 As is well known, the metal annealing process has the characteristics of heat concentration and rapid heating. Traditional vacuum annealing furnaces use PID control method, which has problems such as high temperature fluctuation, large overshoot, and ...
Haitao Gao (594475) +5 more
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Dialectal variation in lexical borrowings in Dangme
Legon Journal of the Humanities, 2022 This paper investigated dialectal variation in lexical borrowings in Dangme, a language spoken in Southern Ghana. Dangme has seven dialects (Ada, Gbugblaa, Yilɔ Krobo, Manya Krobo, Nugo, Sɛ and Osudoku), but this study concerns lexical borrowings into ...
Raymond Teye Akrobettoe +2 more
doaj +1 more source
adrien-ga/Simstrat-BSIW: Simstrat v1.3
, 2017 <p>Simstrat version allowing the use of a filtered wind time series for improved modelling of basin-scale internal waves (BSIWs), as described in the paper gmd-2016-262</p ...
adrien-ga
core +1 more source