Results 61 to 70 of about 4,356,393 (396)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Towards Effective COVID-19 Sentiment Analysis Using Bio-Inspired Feature Optimization
Journal of Communications Software and SystemsAnalyzing sentiments in social media content related to COVID-19 presents major challenges, especially given the sheer volume of data and the complexity of text features.
Mohamed Debbab +4 more
doaj +1 more source
IrCrMnZ (Z = Al, Ga, Si, Ge) Heusler alloys as electrode materials for MgO-based magnetic tunneling junctions: a first-principles study [PDF]
, 2021 Tufan Roy +2 more
openalex +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Journal of Agricultural Sciences, 2009 Araştırmada, günümüzde sadece Ankara – Gölbaşı‟nda sınırlı bir alanda yetişmekte olan endemik bitki Centaure tchihatcheffii Fisch. et Mey. tohumlarının çimlenmeleri üzerine, suda 12 saat ve 24 saat ve GA3çözeltisinde 10 ppm ve 100 ppm‟lik çözeltilerde
Yeşim Okay, Aslı Günöz
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Scientific Reports, 2018 Sensitive High-Resolution Ion Microprobe (SHRIMP) U-Pb analyses of zircons from Paleoarchean (~3.4 Ga) tonalite-gneiss called the Older Metamorphic Tonalitic Gneiss (OMTG) from the Champua area of the Singhbhum Craton, India, reveal 4.24-4.03 Ga ...
T. Chaudhuri +4 more
semanticscholar +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Optimizing Cervical Cancer Classification with SVM and Improved Genetic Algorithm on Pap Smear Images [PDF]
Computer Science Journal of MoldovaThis study presents an approach to optimize cervical cancer classification using Support Vector Machines (SVM) and an improved Genetic Algorithm (GA) on Pap smear images.
S. Umamaheswari +3 more
doaj +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source