Results 251 to 260 of about 163,092 (297)

Exploring the pathophysiology underlying clozapine‐induced enhancement of glutamatergic transmission through L‐glutamate and D‐serine release associated with pannexin1 hemichannels

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada, Ruri Okubo, Eishi Motomura   +2 more
wiley   +1 more source

Neurotransmitter power plays: the synaptic communication nexus shaping brain cancer. [PDF]

Acta Neuropathol Commun
Mondal J, Huse JT.
europepmc   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Repetitive Transcranial Magnetic Stimulation Induces Cognitive Recovery in Alzheimer's Disease via GABAergic Neuron Activation of the Cx3cl1‐Cx3cr1 Axis

Cell Proliferation, EarlyView.
Schematic diagram illustrating the molecular mechanisms of the Cx3cl1‐Cx3cr1 axis mediated by rTMS activation of GABAergic neurons in the process of cognitive function recovery in AD. ABSTRACT This study aimed to investigate the impact of repetitive transcranial magnetic stimulation (rTMS) on cognitive recovery in Alzheimer's disease (AD) by exploring ...
Yunxiao Kang, Jilun Liu, Yu Wang, Jiaying Wang, Jinyang Wang, Chenming Zhou, Rui Cui, Tianyun Zhang   +7 more
wiley   +1 more source

Long-term gamma-aminobutyric acid (GABA) treatment fails to regain beta-cell function in longstanding type 1 diabetes in a randomized trial. [PDF]

Sci Rep
Hill H, Lundkvist P, Tsatsaris G, Birnir B, Espes D, Carlsson PO.   +5 more
europepmc   +1 more source

Evaluation of routine care of prurigo nodularis in Germany: retrospective chart review study (ADVANCE PN)

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Knowledge on patient care gaps of prurigo nodularis (PN) is limited. This retrospective chart review (ADVANCE PN) investigated unmet medical needs and gaps in diagnostics, treatment, and management of patients with PN in routine care in Germany.
Ralph von Kiedrowski, Martin Metz, Elke Weisshaar, Inka Albrecht, Marie Schild, Sonja Ständer   +5 more
wiley   +1 more source

Clinical and functional characterization of the GABRB3 p.Met80Val variant in early-onset epilepsy with long-term follow-up. [PDF]

Ital J Pediatr
Hua R, Jiang J, Wang B, Zhu Z, Wang J, Wu, Yang L.   +6 more
europepmc   +1 more source

Integrated Metabolomic and Transcriptomic Analysis Reveals the Molecular Regulatory Mechanism of Gamma-Aminobutyric Acid Accumulation in White Quinoa (<i>Chenopodium quinoa</i> Willd.) in Response to Dark and Ultrasound Stress. [PDF]

Foods
Wu M, Zhou Q, Sun Y, Zhou L, Li D, Ren T, Zheng Y, Zhao W, Wang J.   +8 more
europepmc   +1 more source

Alterations in gamma-aminobutyric acid and glutamate neurotransmission linked to intermittent theta-burst stimulation in depression: a sham-controlled study. [PDF]

Transl Psychiatry
Steinholtz L, Bodén R, Wall A, Lubberink M, Fällmar D, Persson J.   +5 more
europepmc   +1 more source

Low-intensity pulsed ultrasound irradiation ameliorates gut inflammation and neuroinflammation in mice with DSS-induced colitis. [PDF]

APL Bioeng
Tian S, Hu Y, Zhou Y, Li J, Liu J, Zhou Q.   +5 more
europepmc   +1 more source