Medicinal Research Reviews, EarlyView.ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg +3 more
wiley +1 more source
The beneficial effect of gamma aminobutyric acid on diabetic nephropathy in type 2 diabetic rat model and their offspring. [PDF]
Res Pharm SciRezazadeh H +4 more
europepmc +1 more source
Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors
Medicinal Research Reviews, EarlyView.ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara +3 more
wiley +1 more source
Long-Term Potentiation and Neurotransmitter Expression Change in Dysautonomia Linked to Binge Eating Disorder: Protective Role of Exercise. [PDF]
Biology (Basel)Veladiz-Gracia F +5 more
europepmc +1 more source
A data‐driven algorithm to determine 1H‐MRS basis set composition
Magnetic Resonance in Medicine, EarlyView.Abstract Purpose Metabolite amplitude estimates derived from linear combination modeling of MR spectra depend on the precise list of constituent metabolite basis functions used (the “basis set”). The absence of clear consensus on the “ideal” composition or objective criteria to determine the suitability of a particular basis set contributes to the poor
Christopher W. Davies‐Jenkins +5 more
wiley +1 more source
Metabolic coupling of ROS generation and antioxidant synthesis by the GABA shunt pathway in myeloid-like blood progenitor cells of Drosophila. [PDF]
PLoS GenetGoyal M +5 more
europepmc +1 more source
Magnetic Resonance in Medicine, EarlyView.Abstract Purpose To achieve spectrally resolved in vivo detection of glutamate, glutamine, and glutathione at 3 T. Methods Difference editing of N‐acetylaspartate CH2 protons (NAA‐CH2) combined with a new echo‐time (TE) optimization approach is introduced.
Li An +5 more
wiley +1 more source
Magnetic Resonance in Medicine, EarlyView.Abstract Purpose The goal of CEST imaging is to reveal the underlying tissue composition and exchange. However, quantitative CEST analyses typically require strong assumptions about this same composition and exchange. The goal of this paper is to introduce a new CEST analysis (also applicable to rotating frame relaxation rate R1ρ$$ {R}_{1\uprho ...
Daniel F. Gochberg
wiley +1 more source
Effect of drying conditions on the preservation of selected bioactive compounds in Moringa oleifera aqueous extract: acetic acid, butyric acid, γ-aminobutyric acid, salicin, and glycine. [PDF]
BMC Plant BiolBabarabie M +4 more
europepmc +1 more source
Obesity, EarlyView.ABSTRACT Objective Topiramate is a medication used off‐label, or in combination with phentermine, for the management of obesity. However, its mechanism of action remains elusive. As many obesity medications target the brain, we aimed to determine if topiramate influences the activity of hypothalamic melanocortin neurons known to regulate energy balance.
Moein Minbashi Moeini +4 more
wiley +1 more source