Results 71 to 80 of about 245,202 (346)

Efficient increase of ɣ-aminobutyric acid (GABA) content in tomato fruits by targeted mutagenesis

Scientific Reports, 2017
γ-Aminobutyric acid (GABA) is a non-proteinogenic amino acid that has hypotensive effects. Tomato (Solanum lycopersicum L.) is among the most widely cultivated and consumed vegetables in the world and contains higher levels of GABA than other major crops.
Satoko Nonaka, Chikako Arai, Mariko Takayama, C. Matsukura, H. Ezura   +4 more
semanticscholar   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Glutamate and GABA [PDF]

Neuron, 2001
Regulation of release of inhibitory neurotransmitter is a key element of plasticity in dorsal horn function. In this issue of Neuron, Kerchner et al. report that neurotransmitter release from inhibitory dorsal horn neurons is affected by activation of presynaptic kainate-type glutamate receptors.
openaire   +3 more sources

Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress

Advanced Science, EarlyView.
Acute restraint stress enhances STAT3Ser727 phosphorylation in dopaminergic neurons in mice. This modification promotes the upregulation of GABBR2 and GABRB3, reduces neuronal activity, and contributes to anxiety‐like behavior and diminished reward‐seeking following stress exposure.
Mingshuo Shao, Yi Wu, Haiyang Wang, Chenchun Zhang, Ying Zhu, Yan Jiang, Changyou Jiang, Qiumin Le, Xing Liu, Lan Ma, Feifei Wang   +10 more
wiley   +1 more source

Enhanced inhibitory effects of GABA on renal and hepatic function, molecular profiles, and histological changes in male albino mice

Open Veterinary Journal
Background: The gamma-aminobutyric acid GABA receptors are considered the main inhibitory neurotransmitter receptors in mammalian brain and they have been proved to be existing in non-neuronal cells. Aim: Lorazepam which is one of the benzodiazepines,
Mohammed Abdullah Ajeel, Israa A. Al-Robaiee   +1 more
doaj   +1 more source

Bibliometric Analysis on GABA-A Receptors Research Based on CiteSpace and VOSviewer

Journal of Pain Research, 2023
Xufeng Yu,1,* Zhan Gao,1,* Mingzhou Gao,2 Mingqi Qiao1 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, People’s Republic of China; 2Innovation Research Institute of ...
Yu X, Gao Z, Gao M, Qiao M
doaj  

GABA‐producing Bifidobacterium dentium modulates visceral sensitivity in the intestine

Neurogastroenterology and Motility, 2016
Recurrent abdominal pain is a common and costly health‐care problem attributed, in part, to visceral hypersensitivity. Increasing evidence suggests that gut bacteria contribute to abdominal pain perception by modulating the microbiome‐gut‐brain axis ...
K. Pokusaeva, Chris W. Johnson, Chris W. Johnson, Berkley Luk, Berkley Luk, G. Uribe, Y. Fu, N. Oezguen, N. Oezguen, R. Matsunami, M. Lugo, Yuko Mori‐Akiyama, Yuko Mori‐Akiyama, E. Hollister, E. Hollister, Sara M. Dann, Xuan-Zheng Shi, D. Engler, T. Savidge, T. Savidge, J. Versalovic, J. Versalovic   +21 more
semanticscholar   +1 more source

Parvalbumin Interneuron‐Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker

Advanced Science, EarlyView.
This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan, Yunxuan Wang, Xufan Deng, Shiyu Wu, Yifan Pan, Jun Du, Mei Yu, Bo Liu, Huimei Wang, Zhengyu Zhang, Jinghong Chen, Shuifa Chen, Yizheng Wang, Tara Walker, Perry Bartlett, Jun Ju, Sheng‐Tao Hou   +16 more
wiley   +1 more source

Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies [PDF]

Journal of Pediatric Epilepsy, 2015
Clinical disorders known to affect inherited gamma-amino butyric acid (GABA) metabolism are autosomal recessively inherited succinic semialdehyde dehydrogenase and GABA-transaminase deficiency. The clinical presentation of succinic semialdehyde dehydrogenase deficiency includes intellectual disability, ataxia, obsessive-compulsive disorder and epilepsy
Parviz, Mahsa, Vogel, Kara, Gibson, K. Michael, Pearl, Phillip L   +3 more
openaire   +4 more sources

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Nature Metabolism, 2019
Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (γ-aminobutyric acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet homeostasis.
D. Menegaz, D. W. Hagan, Joana Almaça, C. Cianciaruso, R. Rodriguez-Diaz, J. Molina, Robert M. Dolan, M. Becker, Petra C. Schwalie, Petra C. Schwalie, R. Nano, Fanny Lebreton, Chen Kang, Chen Kang, Rajan Sah, Rajan Sah, H. Gaisano, P. Berggren, P. Berggren, P. Berggren, Steinunn Baekkeskov, Steinunn Baekkeskov, A. Caicedo, Edward A. Phelps, Edward A. Phelps   +24 more
semanticscholar   +1 more source