Results 71 to 80 of about 219,640 (255)

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Current concepts of pathogenesis of depressive disorder: A literature review

Research Results in Pharmacology
Introduction: Despite the high prevalence of depressive disorders, the pathogenesis of depression has not been fully established. Recently, a significant number of works have been published demonstrating mechanisms of development of this pathology that ...
Alexander A. Spasov, Dmitriy V. Maltsev, Maria O. Maltseva   +2 more
doaj   +1 more source

Decreased serum level of gamma-amino butyric acid in egyptian infertile females with polycystic ovary syndrome is correlated with dyslipidemia, total testosterone and 25(OH) vitamin D levels [PDF]

Journal of Medical Biochemistry, 2019
Background: Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders around the world. Increasing evidence suggests that neurotransmitter Gamma-aminobutyric acid (GABA) is involved in the pathogenesis of PCOS through its ...
Radwan Rasha A., Abuelezz Nermeen Z., Abdelraouf Sahar M., Bakee Engy M., Abd-El-rahman Abdullah A.   +4 more
doaj  

An electrophysiological study of the interaction between fenamate NSAIDs and the GABA(_A) receptor [PDF]

, 1999
The effects of certain NSAIDs were determined on agonist-evoked responses recorded from rat neurones maintained in vitro using electrophysiological techniques. Initially, the rat isolated vagus and optic nerves were employed. Alphaxalone, pentobarbitone,
Patten, Debra
core  

Presynaptic actions of 4-Aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro [PDF]

, 1980
Responses to bath-applications of 4-aminopyridine (4-AP) and -aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion.
Ten Bruggencate, Gerrit, Galvan, Martin, Grafe, Peter   +2 more
core   +1 more source

Abstract Representation of Movement Parameters in Basal Ganglia Output

Advanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero, Diana I. Ortega‐Romero, Claudia I. Pérez‐Díaz, Pavel E. Rueda‐Orozco   +3 more
wiley   +1 more source

Synergistic Enhancement of Fecal GABA Content by Bifidobacterium adolescentis 4-2 and Mannooligosaccharides in a Human Intestinal Flora Model

Frontiers in Bioscience-Elite
Background: Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the central nervous system and exerts multiple health-promoting effects, including antidepressant, hypotensive, immunomodulatory, and ...
Hend Altaib, Tohru Suzuki, Takumi Morioka, Mayuko Abe, Yassien Badr   +4 more
doaj   +1 more source

Bibliometric Analysis on GABA-A Receptors Research Based on CiteSpace and VOSviewer

Journal of Pain Research, 2023
Xufeng Yu,1,* Zhan Gao,1,* Mingzhou Gao,2 Mingqi Qiao1 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, People’s Republic of China; 2Innovation Research Institute of ...
Yu X, Gao Z, Gao M, Qiao M
doaj