Results 141 to 150 of about 2,290,618 (347)

Neural mass modeling reveals that hyperexcitability underpins slow‐wave sleep changes in children with epilepsy

Epilepsia, EarlyView.
Abstract Objective The relationship between sleep and epilepsy is important but imperfectly understood. We sought to understand the mechanisms that explain the differences in sleep homeostasis observed in children with epilepsy. Methods We used a neural mass model to replicate sleep electroencephalography (EEG) recorded from 15 children with focal ...
Dominic M. Dunstan, Samantha Y. S. Chan, Marc Goodfellow   +2 more
wiley   +1 more source

Left parietal structural connectivity mediates typical and atypical language laterality in temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Subjects with left temporal lobe epilepsy may either show altered hemispheric language lateralization or retain typical, left lateralization. Examining the integrity of white matter pathways involved in the adaptation or maintenance of language lateralization in these patients could have important clinical implications for preserving
Salvatore Citro, Sam S. Javidi, Ankeeta Ankeeta, Xiaosong He, Qirui Zhang, Yolanda Kry, Michael R. Sperling, Joseph I. Tracy   +7 more
wiley   +1 more source

Immunocytochemical localization of gamma 2 short and gamma 2 long subunits of the GABAA receptor in the rat brain [PDF]

, 1994
Antonia Gutiérrez, Zafar U. Khan, AL de Blas   +2 more
openalex   +1 more source

Voluntary running wheel activity reduces seizure burden and affords neuroprotection in a mouse model of acquired epilepsy

Epilepsia, EarlyView.
Abstract Objective Physical exercise may improve neurological deficits and neuronal damage after acute brain injuries and decrease established seizures. We investigated whether voluntary running wheel (RW) activity affects epileptogenesis in a mouse model of acquired epilepsy compared to sedentary mice.
Valentina Kebede, Rossella Di Sapia, Nicole Tonesi, Massimo Rizzi, Silvia Balosso, Daniele Spallaci, Ilaria Craparotta, Laura Pasetto, Valentina Bonetto, Gerardo Marsella, Luca Porcu, Giorgio Rosati, Alessandro Ieraci, Annamaria Vezzani   +13 more
wiley   +1 more source

Erratum: AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. [PDF]

Front Mol Neurosci, 2023
Frontiers Production Office.
europepmc   +1 more source

ENX‐101, a GABAA receptor α2,3,5‐selective positive allosteric modulator, displays antiseizure effects in rodent seizure and epilepsy models

Epilepsia, EarlyView.
Abstract Objective γ‐Aminobutyric acid type A (GABAA) receptor positive allosteric modulators (PAMs) that lack α‐subunit selectivity, including benzodiazepines such as diazepam, exhibit antiseizure actions in animal models and in humans. ENX‐101 is a deuterated analog of the ⍺2,3,5‐selective GABAA receptor PAM L‐838,417.
Jordi Serrats, Krishna C. Vadodaria, William Brubaker, Melissa Barker‐Haliski, H. Steve White, Alexis Evrard, Corinne Roucard, Eve Taylor, Kimberly E. Vanover, Stephen Cunningham, Vikram Sudarsan, Michael A. Rogawski   +11 more
wiley   +1 more source

AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. [PDF]

Front Mol Neurosci, 2023
Ramsay HJ, Gookin SE, Ramsey AM, Kareemo DJ, Crosby KC, Stich DG, Olah SS, Actor-Engel HS, Smith KR, Kennedy MJ.   +9 more
europepmc   +1 more source

Synaptic inhibitory dynamics drive benzodiazepine response in pediatric status epilepticus

Epilepsia, EarlyView.
Abstract Objective Pediatric status epilepticus (SE) is a medical emergency associated with significant morbidity. Benzodiazepines (BZPs) are the current first‐line treatment, but do not work in more than one third of children presenting with SE. Animal studies have shown that SE can cause changes in synaptic inhibition signaling that can ultimately ...
Tommaso Fedele, Richard J. Burman, Anne Steinberg, Giorgio Selmin, Georgia Ramantani, Richard E. Rosch   +5 more
wiley   +1 more source

Neuroactive steroid exposure impacts neurodevelopment: Comparison of human and rodent placental contribution

Journal of Neuroendocrinology, EarlyView.
Abstract The placenta is a fetal endocrine organ that secretes many neuroactive factors, including steroids, that play critical roles in brain development. The study of the placenta‐brain axis and the links between placental function and brain development represents an emerging research area dubbed “neuroplacentology.” The placenta drives many ...
Claire‐Marie Vacher, Alex Tsompanidis, Morgan R. Firestein, Anna A. Penn   +3 more
wiley   +1 more source

Structural and functional characterization of the gamma 1 subunit of GABAA/benzodiazepine receptors. [PDF]

, 1990
S. Ymer, Andreas Draguhn, William Wisden, P. Werner, Kari Keinänen, Peter R. Schofield, Rolf Sprengel, Dolan B. Pritchett, P. H. Seeburg   +8 more
openalex   +1 more source