Results 141 to 150 of about 80,549 (314)

Activation of TRPA1 and TRPM3 triggers Ca2+ waves in central terminals of sensory neurons and facilitates synaptic activity in the spinal dorsal horn

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Transient receptor potential ankyrin 1 (TRPA1) and melastatin 3 (TRPM3) activation regulate pre‐ and postsynaptic Ca2+ concentrations and synaptic activity in the dorsal horn of the spinal cord. Left: a model that describes how activation of TRPA1 and TRPM3 channels induces an influx of Ca2+ in the central terminals of sensory ...
Yaroslav E. Andrianov   +10 more
wiley   +1 more source

GluN2C/D‐containing NMDA receptors enhance temporal summation and increase sound‐evoked and spontaneous firing in the inferior colliculus

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Here, we find that GluN2D‐containing NMDA receptors (NMDARs) are expressed by most vasoactive intestinal peptide neurons in the inferior colliculus (IC). These receptors are less susceptible to Mg2+ blockade compared to GluN2A/B‐containing NMDARs, allowing ions to flow at resting membrane potential.
Audrey C. Drotos   +3 more
wiley   +1 more source

Adaptations to hypoxia in the vertebrate retina

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Most animals, including mammals, are susceptible to the damaging effects of hypoxia or ischaemia, where the result is neuronal cell death in the brain. By contrast, some neurons of the mammalian retina are less sensitive to hypoxia. In both brain and retina, neurons may survive if first preconditioned with ischaemia.
Michael G. Jonz
wiley   +1 more source

AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. [PDF]

open access: yesFront Mol Neurosci, 2023
Ramsay HJ   +9 more
europepmc   +1 more source

Neonatal Procedural Pain Disrupts Phosphorylation of KCC2 in the Spinal Cord

open access: yesDevelopmental Neurobiology, Volume 85, Issue 4, October 2025.
ABSTRACT Neonatal procedural pain experienced in the neonatal intensive care unit can lead to long‐lasting remodeling of the central nervous system and, in particular, of the spinal nociceptive network. Preclinical studies indicate a disrupted inhibitory versus excitatory balance in the spinal cord due to reduced γ‐aminobutyric acid (GABA) ergic ...
Mathilde Baudat   +4 more
wiley   +1 more source

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