Results 201 to 210 of about 2,290,618 (347)

The GABAA receptor is an FMRP target with therapeutic potential in fragile X syndrome

Cell Cycle, 2015
S. Braat, C. D’Hulst, Inge Heulens, S. Rubeis, E. Mientjes, D. Nelson, R. Willemsen, Claudia Bagni, Claudia Bagni, D. Dam, P. P. Deyn, R. Kooy   +11 more
semanticscholar   +1 more source

GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases

MedComm, Volume 6, Issue 5, May 2025.
Within the GABAergic system, GABABRs are potential therapeutic targets for dealing multiple metabolic and binge eating disorders and food addiction. Allosteric modulators and small peptides targeting GABABR signaling pathways may be developed as attractive drug candidates that avoid the side effects of agents that directly bind these receptors ...
Weijie Xie, Yuan Li, Xinyue Wang, Elena Blokhina, Evgeny Krupitsky, Marina Vetrova, Ji Hu, Ti‐Fei Yuan, Jue Chen, Hua Wang, Xiangfang Chen   +10 more
wiley   +1 more source

Editorial: The GABAA receptor: a target of pharmacologically active molecules. [PDF]

Front Pharmacol
Ernst M, Lu W, Mattei C.
europepmc   +1 more source

GABA_A Receptor Subtype Specificity in Essential Tremor. [PDF]

Neurotherapeutics, 2023
Kuo SH.
europepmc   +1 more source

Comprehensive chemoanatomical mapping, and the gonadal regulation, of seven kisspeptin neuronal populations in the mouse brain

Journal of Neuroendocrinology, Volume 37, Issue 5, May 2025.
Abstract Kisspeptinergic signaling is well‐established as crucial for the regulation of reproduction, but its potential broader role in brain function is less understood. This study investigates the distribution and chemotyping of kisspeptin‐expressing neurons within the mouse brain.
Vito S. Hernández, Mario A. Zetter, Oscar R. Hernández‐Pérez, Rafael Hernández‐González, Ignacio Camacho‐Arroyo, Robert P. Millar, Lee E. Eiden, Limei Zhang   +7 more
wiley   +1 more source

The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders

Neuron, 2015
S. Braat, R. Kooy
semanticscholar   +1 more source

Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity

Angewandte Chemie International Edition, Volume 64, Issue 18, April 25, 2025.
A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt, Yassmine El Harraoui, Alex Rothemann, Adrian T. Jauch, Sigrid Müller‐Deubert, Martin F. Köllen, Timo Risch, Lianne JHC Jacobs, Rolf Müller, Franziska R. Traube, Denitsa Docheva, Stefan Zahler, Jan Riemer, Nina C. Bach, Stephan A. Sieber   +14 more
wiley   +1 more source

Inhibition of GABAA receptor-mediated current responses by enoxacin (new quinolone) and felbinac (non-steroidal anti-inflammatory drug) in Xenopus oocytes injected with mouse-brain messenger RNA.

, 1993
Junichi Kawakami, Masafumi SHIMOKAWA, Koujirou YAMAMOTO, Yasufumi Sawada, Atsushi Asanuma, Keiji Yanagisawa, Tatsuji IGA   +6 more
openalex   +2 more sources

Distinct Impact of Inflammatory Versus Psychophysiological Stress on Brain‐Wide Activation of Melanocortin Receptor 4–Expressing Neurons

The FASEB Journal, Volume 39, Issue 7, 15 April 2025.
Restraint stress and LPS‐induced inflammation commonly decrease food intake and body weight in male mice. Although both stressors increased c‐Fos expression in the PVN, the activation patterns diverge in several key brain regions. Restraint stress preferentially increased c‐Fos expression in the lateral septum, ventral BNST, and BLA, whereas LPS ...
Myunghyun Cheon, Woonhee Kim, ChiHye Chung   +2 more
wiley   +1 more source

Novel pyrazolothienopyridinones as potential GABA_A receptor modulators. [PDF]

Monatsh Chem, 2023
Vega Alanis BA, Wimmer L, Ernst M, Schnürch M, Mihovilovic MD.   +4 more
europepmc   +1 more source