Results 271 to 280 of about 80,549 (314)
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2001
Studies of human diseases of the nervous system have demonstrated that many of the disorders result from disruption of normal developmental processes which promote organization and maturation of neuronal circuitry. Such disorders include many different forms of inherited childhood epilepsies in which genetic factors contribute to the abnormal ...
H. Y. Kim, R. W. Olsen
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Studies of human diseases of the nervous system have demonstrated that many of the disorders result from disruption of normal developmental processes which promote organization and maturation of neuronal circuitry. Such disorders include many different forms of inherited childhood epilepsies in which genetic factors contribute to the abnormal ...
H. Y. Kim, R. W. Olsen
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2014
γ-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain and its actions are mediated by two diverse families of neurotransmitter receptors, the ionotropic receptors, known as GABAA receptors, and metabotropic receptors that are classified as GABAB receptors.
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γ-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain and its actions are mediated by two diverse families of neurotransmitter receptors, the ionotropic receptors, known as GABAA receptors, and metabotropic receptors that are classified as GABAB receptors.
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Spectrum of GABAA receptor variants in epilepsy
Current Opinion in Neurology, 2019Purpose of review Recent publications point to an increasingly important role of variants in genes encoding GABAA receptor subunits associated with both common and rare forms of epilepsies. The aim of this review is to give an overview of the current clinical phenotypes, genetic findings and pathophysiological mechanisms ...
Maljevic, Snezana +6 more
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The GABAA receptor family in the mammalian brain
Neurochemical Research, 1991The GABAA-benzodiazepine receptor protein from bovine brain was purified by affinity chromatography and the subunit composition examined by gel electrophoresis in sodium dodecyl sulfate. Protein staining revealed a doublet at 51-53 kDa, a band at 55 kDa, and a broad band at 57-59 kDa.
Geoffrey B. Smith +3 more
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2010
Publisher Summary This chapter discusses the gamma-aminobutyric acid (GABA) receptor channels, which are the most abundant inhibitory neurotransmitter in the CNS. Following release from presynaptic vesicles, GABA exerts fast inhibitory effects by interacting with GABA receptors, whose primary function is to hyperpolarize neuronal membranes in mature ...
Emmanuel J. Botzolakis +1 more
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Publisher Summary This chapter discusses the gamma-aminobutyric acid (GABA) receptor channels, which are the most abundant inhibitory neurotransmitter in the CNS. Following release from presynaptic vesicles, GABA exerts fast inhibitory effects by interacting with GABA receptors, whose primary function is to hyperpolarize neuronal membranes in mature ...
Emmanuel J. Botzolakis +1 more
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Schizophrenia and GABAA receptor subunit genes
Psychiatric Genetics, 1995Alterations in gamma-aminobutyric acid (GABA) neurotransmission have been indirectly implicated in the pathogenesis of schizophrenia. Using nine multiplex pedigrees, we tested for linkage between schizophrenia and simple sequence repeat polymorphisms for the GABAA receptor alpha 1, alpha 2, alpha 4, alpha 5, alpha 6, beta 1 and beta 3 subunit genes ...
Robert Freedman +14 more
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Plasticity of the α4βδ GABAA receptor
Biochemical Society Transactions, 2009The GABAR [GABAA (γ-aminobutyric acid type A) receptor], which mediates most inhibition in the brain, is regulated homoeostatically to maintain an optimal level of neuronal excitability. In particular, the α4βδ subtype of the GABAR plays a pivotal role in this regulation.
Sheryl S. Smith, Hui Shen
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Hijacking of GABAA Receptors by Mutant Glycine Receptors
Trends in Molecular Medicine, 2019Startle disease results from mutations in genes encoding inhibitory GlyR α1 and β subunits or the presynaptic glycine transporter GlyT2. However, the most effective therapies are benzodiazepines that potentiate inhibitory GABAAR function. A recent publication by Zou et al.
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Tyrosine kinase phosphorylation of GABAA receptors
Molecular Brain Research, 1995Phosphorylation of purified bovine brain GABAA receptors by the tyrosine kinase, pp60v-src was examined. pp60v-src phosphorylated two bands of 54-62 kDa and 48-51 kDa that migrated to approximately the same position as bands recognized by antisera against the beta 2 and gamma 2 GABAA receptor subunits, respectively.
Geoffrey B. Smith +10 more
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The Selective Interaction of Neurosteroids with the GABAA Receptor
1999Some endogenous pregnane steroids have long been known to produce rapid sedative and anesthetic effects (1). The speed of onset of these behavioral effects precludes a genomic mechanism of action for such steroids, but it was not until Harrison and Simmonds (2)demonstrated that a synthetic steroidal anesthetic, alphaxalone (3α-hydroxy-5α-pregnane-11,20-
LAMBERT J. J. +4 more
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