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Microglial activation drives neuronal dysregulation in alcohol-induced seizure susceptibility. [PDF]
Sci RepZhang S +9 more
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Scientific American, 1988
One tends to think of the nervous system in terms of chains of excitatory signals that tell neurons to fire. The signals that say "Don't fire" also have a major role. Inhibitory signals damp overall neural activity and also fine-tune the responses of particular circuits. The primary carrier of these signals is the inhibitory transmitter known as GABA.
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One tends to think of the nervous system in terms of chains of excitatory signals that tell neurons to fire. The signals that say "Don't fire" also have a major role. Inhibitory signals damp overall neural activity and also fine-tune the responses of particular circuits. The primary carrier of these signals is the inhibitory transmitter known as GABA.
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Neuroscience, 2008
The deep cerebellar nuclei (DCN) are the final integrative units of the cerebellar network. The strongest single afferent to the DCN is formed by GABAergic Purkinje neuron axons whose synapses constitute the majority of all synapses in the DCN, with their action strongly regulating the intrinsic activity of their target neurons.
M, Uusisaari, T, Knöpfel
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The deep cerebellar nuclei (DCN) are the final integrative units of the cerebellar network. The strongest single afferent to the DCN is formed by GABAergic Purkinje neuron axons whose synapses constitute the majority of all synapses in the DCN, with their action strongly regulating the intrinsic activity of their target neurons.
M, Uusisaari, T, Knöpfel
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Journal of Comparative Neurology, 2005
AbstractThe glutamate receptor‐interacting protein GRIP1 is present in glutamatergic synapses and interacts with the GluR2/3/4c subunits of the AMPA receptors. This interaction plays important roles in trafficking, synaptic targeting, and recycling of AMPA receptors as well as in the plasticity of glutamatergic synapses.
Rong-Wen, Li +7 more
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AbstractThe glutamate receptor‐interacting protein GRIP1 is present in glutamatergic synapses and interacts with the GluR2/3/4c subunits of the AMPA receptors. This interaction plays important roles in trafficking, synaptic targeting, and recycling of AMPA receptors as well as in the plasticity of glutamatergic synapses.
Rong-Wen, Li +7 more
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Neurochemical Research, 1998
GABA is the major inhibitory neurotransmitter in the mammalian brain, and has been implicated in the regulation of a variety of behavioral functions, including biological rhythms. The focus of this minireview is the rhythmic variation of the central GABAergic system, comprising fluctuations of GABA levels and turnover, GABA receptor affinity and ...
D P, Cardinali, D A, Golombek
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GABA is the major inhibitory neurotransmitter in the mammalian brain, and has been implicated in the regulation of a variety of behavioral functions, including biological rhythms. The focus of this minireview is the rhythmic variation of the central GABAergic system, comprising fluctuations of GABA levels and turnover, GABA receptor affinity and ...
D P, Cardinali, D A, Golombek
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GABAergic Involvement in Selective Attention
Journal of Cognitive Neuroscience, 2023AbstractAnimals need to cope with abundant sensory information, and one strategy is to selectively direct attention to only the most relevant part of the environment. Although the cortical networks of selective attention have been studied extensively, its underlying neurotransmitter systems, especially the role of the inhibitory neurotransmitter gamma ...
Kaja Faßbender +6 more
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Gabaergic mechanisms in antinociception
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1984GABAergic mechanisms appear to be involved in antinociceptive processes. Generally, peripheral administration of GABAergic agents increases the antinociceptive effect of morphine, but central administration inhibits this effect, suggesting that multiple interactions may occur. GABAergic agents also can produce antinociception directly.
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GABAergic microcircuits in the neostriatum
Trends in Neurosciences, 2004The vast majority of neostriatal neurons and intrinsic intrastriatal synapses are GABAergic, the latter arising from axon collaterals of spiny projection neurons and from GABAergic interneurons. An important feature of the functional organization of the neostriatum has long been assumed to be the existence of a widespread lateral inhibitory network ...
James M, Tepper +2 more
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Mechanisms regulating GABAergic neuron development
Cellular and Molecular Life Sciences, 2013Neurons using gamma-aminobutyric acid (GABA) as their neurotransmitter are the main inhibitory neurons in the mature central nervous system (CNS) and show great variation in their form and function. GABAergic neurons are produced in all of the main domains of the CNS, where they develop from discrete regions of the neuroepithelium.
Partanen Juha +2 more
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