Results 51 to 60 of about 179,337 (237)

Involvement of the GABAergic system in PTSD and its therapeutic significance

Frontiers in Molecular Neuroscience, 2023
The neurobiological mechanism of post-traumatic stress disorder (PTSD) is poorly understood. The inhibition of GABA neurons, especially in the amygdala, is crucial for the precise regulation of the consolidation, expression, and extinction of fear ...
Junhui Huang, Fei Xu, Liping Yang, Lina Tuolihong, Xiaoyu Wang, Zibo Du, Yiqi Zhang, Xuanlin Yin, Yingjun Li, Kangrong Lu, Wanshan Wang   +10 more
doaj   +1 more source

Development of Cortical GABAergic Innervation [PDF]

Frontiers in Cellular Neuroscience, 2011
The mature neocortex contains many different classes of GABAergic inhibitory interneurons, distributed, with some degree of selectivity, through six layers, and through many different regions. Some of the events in the early lives of these neurones that may determine their ultimate destination, their maturation and their selective innervation of ...
Jovanovic, JN, Thomson, AM
openaire   +4 more sources

Primate-specific origins and migration of cortical GABAergic neurons

Frontiers in Neuroanatomy, 2009
Gamma-aminobutyric-acidergic (GABAergic) cells form a very heterogeneous population of neurons that play a crucial role in the coordination and integration of cortical functions. Their number and diversity increase through mammalian brain evolution. Does
Zdravko Petanjek, Zdravko Petanjek, Ivica Kostovic, Monique Esclapez   +3 more
doaj   +1 more source

Genetically altered AMPA-type glutamate receptor kinetics in interneurons disrupt long-range synchrony of gamma oscillation [PDF]

, 2001
Gamma oscillations synchronized between distant neuronal populations may be critical for binding together brain regions devoted to common processing tasks.
A. Bibbig, A. Caputi, Ali, Angulo, Aroniadou, Asada, Bonnerot, Buhl, Catania, Catania, Csicsvari, E. C. Fuchs, Erlander, Ermentrout, Esclapez, Geiger, Geiger, Gu, Guly  s, H. Doheny, H. Faulkner, H. Monyer, He, Hestrin, Jonas, Karbowski, Kondo, Lambolez, Leranth, M. A. Whittington, Mahanty, Martina, Miles, Mosbacher, Mountford, Murakoshi, N. Kopell, Nagy, Petralia, R. D. Traub, Racca, Rozov, Singer, Sommer, Szab  , Traub, Traub, Traub, T  th, Vissavajjhala, Whittington, Whittington   +51 more
core   +3 more sources

Preterm Birth Alters the Maturation of the GABAergic System in the Human Prefrontal Cortex

Frontiers in Molecular Neuroscience, 2022
Developmental changes in GABAergic and glutamatergic systems during frontal lobe development have been hypothesized to play a key role in neurodevelopmental disorders seen in children born very preterm or at/with low birth weight, but the associated ...
Helene Lacaille, Claire-Marie Vacher, Anna A. Penn   +2 more
doaj   +1 more source

Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine [PDF]

, 2013
Nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nAChRs) and boosting dopamine (DA) output from the ventral tegmental area (VTA).
A Taly, AA Grace, AJ Yu, AO Komendantov, AR Tapper, B Buisson, B Katz, Boris Gutkin, C Lüscher, C Shelley, CP Fenster, DB Carr, E Lichtenstein, E Sher, EJ Nestler, F Marti, FE Pontieri, G Di Chiara, G Di Chiara, G Di Chiara, GL Forster, HD Mansvelder, HD Mansvelder, HR Wilson, IW Jones, J Cornwall, J Grenhoff, JA Dani, Ja Dani, JB Eaton, JE Henningfield, JE Rose, JN Reynolds, JP Changeux, JP Changeux, JP Changeux, JR Clements, JR Wooltorton, K Chergui, Karl J. Friston, KG Paradiso, LE Chavez-Noriega, M Gao, M Garzón, M Graupner, M Mameli-Engvall, M Wu, MG Lacey, Michael Graupner, MJ Christie, MR Picciotto, MR Picciotto, N Champtiaux, P Dayan, PW Kalivas, R Exley, R Giniatullin, R Klink, R Nashmi, Reinoud Maex, RL Papke, S Erhardt, S Ikemoto, S Tolu, SA Oakman, SC Steffensen, SR Grady, SR Sesack, SW Johnson, SW Johnson, TC Jhou, V David, V Gerzanich, V Gerzanich, VI Pidoplichko, WA Corrigall, X Peng, ZM Fagen, ZY Tong   +78 more
core   +6 more sources

GABAergic dysfunction in mood disorders [PDF]

Molecular Psychiatry, 2003
The authors review the available literature on the preclinical and clinical studies involving GABAergic neurotransmission in mood disorders. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter present almost exclusively in the central nervous system (CNS), distributed across almost all brain regions, and expressed in interneurons ...
BRAMBILLA P, PEREZ J, SCHETTINI G, SOARES J.C., BARALE, FRANCESCO   +4 more
openaire   +4 more sources

GABAergic synapses from the ventral lateral septum to the paraventricular nucleus of hypothalamus modulate anxiety

Frontiers in Neuroscience
Emotional disorders, such as anxiety and depression, represent a major societal problem; however, the underlying neurological mechanism remains unknown. The ventral lateral septum (LSv) is implicated in regulating processes related to mood and motivation.
Ying-Juan Liu, Yan Wang, Jiao-Wen Wu, Jie Zhou, Bai-Lin Song, Yi Jiang, Lai-Fu Li   +6 more
doaj   +1 more source

Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis. [PDF]

PLoS ONE, 2015
GABAergic neurons are the primary inhibitory cell type in the mature brain and their dysfunction is associated with important neurological conditions like schizophrenia and anxiety.
Clara-Zoe Wende, Saida Zoubaa, Alexandra Blak, Diego Echevarria, Salvador Martinez, François Guillemot, Wolfgang Wurst, Jordi Guimera   +7 more
doaj   +1 more source

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]

, 2019
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong, Jones, Emily A, Najm, Ramsey   +2 more
core   +1 more source