Results 251 to 260 of about 759,534 (341)

Respiratory dysfunction and fatal apnea during pilocarpine‐induced status epilepticus

Epilepsia, EarlyView.
Abstract Objective Status epilepticus (SE) is second only to sudden unexpected death in epilepsy as a cause of seizure‐related mortality. The progression of respiratory dysfunction during experimental SE remains poorly characterized. We investigated how pilocarpine‐induced SE affects respiration in mice.
Chengsan Sun, Rachel Spera, John M. Williamson, Suchitra Joshi, Bhavya Guduru, Harini Ganabady, Jaideep Kapur   +6 more
wiley   +1 more source

Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats

Epilepsia, EarlyView.
Abstract Objective For over four decades, the substantia nigra pars reticulata (SNr) has been recognized as a critical structure in the modulation of seizure activity. Pharmacological and optogenetic inhibition of the SNr produces robust seizure suppression in a range of seizure models.
Devin Palmer, Patrick A. Forcelli
wiley   +1 more source

Ethanol Enhances GABAergic Transmission Onto Dopamine Neurons in the Ventral Tegmental Area of the Rat

, 2008
Jonathan W. Theile, Hitoshi Morikawa, Reuben A. Gonzales, Richard A. Morrisett   +3 more
openalex   +1 more source

Spreading depolarization and its influence on epileptiform activity

Epilepsia, EarlyView.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

Mesoscopic analysis of GABAergic marker distribution in cholinergic neurons in the mouse brain

Goral, Rene Oliver, Roy, Snehashis, Yakel, Jerrel Louis, Usdin, Theodore B.   +3 more
openalex   +1 more source

A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex

Neuron, 2011
H. Taniguchi, Miao He, Priscilla Wu, Sangyong Kim, Raehum Paik, Ken Sugino, Duda Kvitsani, Yu Fu, Jiangteng Lu, Ying Lin, G. Miyoshi, Yasuyuki Shima, G. Fishell, S. Nelson, Z. J. Huang   +14 more
semanticscholar   +1 more source

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

Epilepsia, EarlyView.
Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa, Laura Bellingacci, Jacopo Canonichesi, Valentina Imperatore, Anna Aurora Taddei, Luis Zafra‐Puerta, Nerea Iglesias‐Cabeza, Paolo Prontera, Andrea Mancini, Massimiliano Di Filippo, Alessandro Tozzi, Katiuscia Martinello, Marta Barzasi, Fabrizio Gardoni, Marina P. Sánchez, José M. Serratosa, Lucilla Parnetti, Miriam Sciaccaluga   +17 more
wiley   +1 more source

Rebound Bursts in GABAergic Neurons of the Thalamic ReticularNucleus in Postnatal Mice

, 2010
X Wang, Guohua Yu, Xin Hou, Jing Zhou, Bo Yang, L Zhang   +5 more
openalex   +1 more source

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

Epilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante, Anna L. Tyler, Rod C. Scott, Amanda E. Hernan, J. Matthew Mahoney   +4 more
wiley   +1 more source

Human Spinal Cord GABAergic Neural Progenitor Cell

Cell Proliferation, EarlyView.
Jia Xu, Xiaoqing Zhang, Aijin Ma, Jie Hao, Tianqing Li, Boqiang Fu, Lixiang Ma, Yan Liu, Peng Xiang, Kun Qian, Xiaohua Han, Yajie Li, Lijun Zhu, Qiyuan Li, Qiang Wei, Tingting Wu, Lei Wang, Jiani Cao, Ka Li, Hongling Zhao, ShuaiShuai Niu, Baoyang Hu, Tongbiao Zhao, Hong Chen   +23 more
wiley   +1 more source