Results 271 to 280 of about 759,534 (341)

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

An epidermal membrane-associated periodic skeleton restricts endocytosis to stabilize neuron-epidermal attachment and preserve axons. [PDF]

Sci Adv
Coakley S, Bonacossa-Pereira I, Le D, Hilliard MA.   +3 more
europepmc   +1 more source

A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring

Obesity Reviews, EarlyView.
ABSTRACT Obesity is one of the most prevalent health problems worldwide, and global obesity rates continue to rise. Consequently, rates of obesity in expecting mothers and fathers have also increased. The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early‐life exposure to adverse environmental conditions contributes to
Hannah Chadwick, Victorio Bambini Junior, Neil Dawson, Cheryl A. Hawkes   +3 more
wiley   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial

Transfusion, EarlyView.
Abstract Background Traumatic brain injury (TBI) carries significant mortality and morbidity in civilian and military populations. Current treatment guidelines for TBI are primarily supportive, and no pharmacological agent exists to attenuate the progression of brain injury.
Maxime A. Visa, Marjorie R. Liggett, Sharnia Lashley, Umar Bhatti, Zaiba A. Dawood, Alvin Anand, Nathan P. Gill, Denise M. Scholtens, Bowen Wang, Hasan B. Alam   +9 more
wiley   +1 more source

Correction: Quantifying harmony between direct and indirect pathways in the basal ganglia: healthy and Parkinsonian states. [PDF]

Cogn Neurodyn
Kim SY, Lim W.
europepmc   +1 more source

Fmr1 knockout disrupts multiple intrinsic properties via reduced HCN channel activity in mediodorsal thalamocortical neurons

Experimental Physiology, EarlyView.
Abstract The neurodevelopmental disorder fragile X syndrome (FXS) results from hypermethylation of the FMR1 gene, which prevents production of the FMRP protein. FMRP modulates the expression and function of a variety of proteins, including voltage‐gated ion channels, such as hyperpolarization‐activated and cyclic nucleotide‐gated (HCN) channels, which ...
Gregory J. Ordemann, Polina Lyuboslavsky, Alena Kizimenko, Audrey C. Brumback   +3 more
wiley   +1 more source

Stroke and motor outcomes are associated with regional and age‐specific changes in periodic and aperiodic cortical activity

Experimental Physiology, EarlyView.
Abstract Historically, stroke and ageing have been associated with changes in narrow‐band periodic neuronal activity, but recent work has highlighted the importance of broad‐band aperiodic activity. Aperiodic activity is represented by the 1/f slope of power spectral density generated by cortical activity.
Asher J. Albertson, Eric C. Landsness, Margaret Eisfelder, Brittany M. Young, Bradley Judge, Matthew R. Brier, Matthew J. Euler, Steven C. Cramer, Jin‐Moo Lee, Keith R. Lohse   +9 more
wiley   +1 more source