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Behavioral consequences of GABAergic neuronal diversity
Current Opinion in Neurobiology, 2014The majority of cellular diversity in the hippocampus and neocortex derives from a relatively small population of local inhibitory interneurons. Recent technological advances have facilitated the recording and manipulation of defined inhibitory cell classes in awake rodents, revealing new and surprising roles for these cells in local circuit function ...
Matthew, Lovett-Barron, Attila, Losonczy
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Scientific American, 1988
One tends to think of the nervous system in terms of chains of excitatory signals that tell neurons to fire. The signals that say "Don't fire" also have a major role. Inhibitory signals damp overall neural activity and also fine-tune the responses of particular circuits. The primary carrier of these signals is the inhibitory transmitter known as GABA.
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One tends to think of the nervous system in terms of chains of excitatory signals that tell neurons to fire. The signals that say "Don't fire" also have a major role. Inhibitory signals damp overall neural activity and also fine-tune the responses of particular circuits. The primary carrier of these signals is the inhibitory transmitter known as GABA.
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Telencephalic origin of human thalamic GABAergic neurons
Nature Neuroscience, 2001In non-primate mammalian species, telencephalic and diencephalic neurons originate from their respective local proliferative zones. Using vital dye labeling in organotypic slice cultures, we show that in human brain, a contingent of neurons from the ganglionic eminence of the telencephalon migrate to the dorsal thalamic association nuclei of the ...
K, Letinic, P, Rakic
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Sex Differentiation of Rat Hippocampal GABAergic Neurons
European Journal of Neuroscience, 1996AbstractIn order to analyse mechanisms of sex differentiation of the hippocampus at the cellular level, the differentiation of hippocampal GABAergic neurons was studied in vitro. Serum‐supplemented and serum‐free dissociated cell cultures were raised from the hippocampus of embryonic day 17 male and female rat embryos for up to 14 days in vitro.
Reisert, Ingrid +3 more
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GABAergic septohippocampal neurons contain parvalbumin
Brain Research, 1989Septal axons were visualized in the hippocampus by anterograde transport of Phaseolus vulgaris leucoagglutinin (PHAL) injected into the medial septal region, which contains large numbers of parvalbumin (PV)-immunoreactive somata. A proportion of the PHAL-labelled afferents in the hippocampus were shown to be immunoreactive for PV by immunostaining ...
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GABAergic input to cholinergic nucleus basalis neurons
Neuroscience, 1998The potential influence of GABAergic input to cholinergic basalis neurons was studied in guinea-pig basal forebrain slices. GABA and its agonists were applied to electrophysiologically-identified cholinergic neurons, of which some were labelled with biocytin and confirmed to be choline acetyltransferase-immunoreactive.
Khateb, Asaid +5 more
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Effect of diazepam on gabaergic cuneate neurons
Neuropharmacology, 1979Abstract Diazepam may act as a γ-aminobutyric acid (GABA) agonist in the CNS, but the evidence is conflicting. This study done with iontophoresis demonstrated that diazepam inhibited the spontaneously firing neurons in the cuneate nucleus, also inhibited by GABA.
R L, Polzin, C D, Barnes
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The long and short of GABAergic neurons
Current Opinion in Neurobiology, 2013GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the adult brain. Studies on GABAergic cells have focused almost exclusively on local interneurons neglecting those inhibitory neurons projecting to different brain areas, the 'long-range GABAergic cells'.
Antonio, Caputi +3 more
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GABAergic control of substantia nigra dopaminergic neurons
2007At least 70% of the afferents to substantia nigra dopaminergic neurons are GABAergic. The vast majority of these arise from the neostriatum, the external globus pallidus and the substantia nigra pars reticulata. Nigral dopaminergic neurons express both GABA(A) and GABA(B) receptors, and are inhibited by local application of GABA(A) or GABA(B) agonists ...
James M, Tepper, Christian R, Lee
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GABAergic Transcallosal Neurons in Developing Rat Neocortex
European Journal of Neuroscience, 1997AbstractIn the mature cerebral cortex the interhemispheric connections across the corpus callosum appear to be essentially completely excitatory on the basis of both immunocytochemical and electrophysiological studies. During late embryonic development, however, immunocytochemical staining reveals numerous GABA‐positive fibres in the callosum, which ...
F, Kimura, R W, Baughman
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