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Orexin (hypocretin)/dynorphin neurons control GABAergic inputs to tuberomammillary neurons

European Journal of Neuroscience, 2004
AbstractHigh activity of the histaminergic neurons in the tuberomammillary (TM) nucleus increases wakefulness, and their firing rate is highest during waking and lowest during rapid eye movement sleep. The TM neurons receive a prominent innervation from sleep‐active γ‐aminobutyric acidergic (GABAergic) neurons in the ventrolateral preoptic nucleus ...
Krister S, Eriksson   +3 more
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Gabaergic transmission by POA neurons to orexin neurons

Sleep Medicine, 2013
Introduction Populations of neurons in the hypothalamic preoptic area (POA) fire rapidly during sleep, exhibiting sleep/waking state-dependent firing patterns that are the reciprocal of those observed in the arousal system. The majority of these preoptic_gsleep-active_h neurons contain the inhibitory neurotransmitter GABA. These neurons are thought to
Y. Saito   +5 more
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LiCl promotes survival of GABAergic neurons from cerebellum and cerebral cortex: LiCl induces survival of GABAergic neurons

Neuroscience Letters, 1994
Previous studies showed that LiCl promotes short-term survival of PC12 cells after NGF or serum deprivation. In the present work, we investigate the survival effect of lithium on cerebellar granule primary cultures. While the total population of cerebellar neurons, mainly granule cells, showed only a short-term survival (about 20 h) in the presence of ...
C, Volonte, M T, Ciotti, D, Merlo
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Origin of GABAergic neurons in the human neocortex

Nature, 2002
The mammalian neocortex contains two major classes of neurons, projection and local circuit neurons. Projection neurons contain the excitatory neurotransmitter glutamate, while local circuit neurons are inhibitory, containing GABA. The complex function of neocortical circuitry depends on the number and diversity of GABAergic (gamma-aminobutyric-acid ...
Kresimir, Letinic   +2 more
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The neuronal identity bias behind neocortical GABAergic plasticity

Trends in Neurosciences, 2015
In the neocortex, different types of excitatory and inhibitory neurons connect to one another following a detailed blueprint, defining functionally-distinct subnetworks, whose activity and modulation underlie complex cognitive functions. We review the cell-autonomous plasticity of perisomatic inhibition onto principal excitatory neurons.
Camille, Allene   +2 more
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Impaired Organization of GABAergic Neurons Following Prenatal Hypoxia

Neuroscience, 2018
Several conditions related to the intrauterine environment are associated with neuropsychiatric conditions in later life. In humans, approximately 2% of infants are exposed to perinatal hypoxia-ischemia or prolonged anoxic insult, a condition to which very low birth weight preterm infants exhibit the highest susceptibility.
Haya, Nisimov   +3 more
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Making glutamatergic neurons from GABAergic progenitors

Nature Neuroscience, 2010
The mature phenotype of CNS neurons is thought to be set at an early progenitor stage. A study now shows that expression of Fezf2 alone can turn striatal GABAergic precursors into glutamatergic corticofugal neurons.
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Artificial Neuron Devices

Chemical Reviews, 2023
Xiaodong Chen
exaly  

Type III neurons’ relationship with type II neurons (GABAergic neurons)

MedScien
Dopamine is the neurotransmitter known as a hormone. As it communicates messages between nerve cells, it plays an essential role in the reward prediction error (RPE), which measures the discrepancy between reality and expectation. In the past experiments conducted by Cohen et al., the researchers developed a system of three types of neurons that play ...
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GABAergic Neurons in the Myenteric Plexus

1992
Some 20 years ago, Hobbiger [8] speculated on the basis of pharmacological studies that GABA, then recently discovered as a constituent of nervous tissue, might have a role in neurotransmission in the enteric nervous system of the vertebrate gut. Subsequent work, however, soon focussed on GABA in relation to the vertebrate central nervous system ...
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