Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care
Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley +5 more
wiley +1 more source
Mineralocorticoid receptor signaling in GABAergic neurons regulates stress-induced cognitive flexibility. [PDF]
Yang H +9 more
europepmc +1 more source
The basal ganglia and the epilepsies
Abstract The basal ganglia are an evolutionarily conserved neural circuit best known for the selection and sequencing of voluntary movement. Increasing evidence, however, indicates that these structures also play an important role in regulating pathological brain states, including seizures.
Willian Lazarini‐Lopes +2 more
wiley +1 more source
SNAP47 Silencing Impairs the Morphology and Neurotransmission of Hippocampal GABAergic Neurons. [PDF]
He Z +6 more
europepmc +1 more source
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley +1 more source
Selective enrichment of TCF4 in GABAergic neurons during postnatal primate development. [PDF]
Burette AC +9 more
europepmc +1 more source
Research progress on the depth of anesthesia monitoring based on the electroencephalogram
Electroencephalogram (EEG) can noninvasive, continuous, and real‐time monitor the state of brain electrical activity, and the monitoring of EEG can reflect changes in the depth of anesthesia (DOA). The development of artificial intelligence can enable anesthesiologists to extract, analyze, and quantify DOA from complex EEG data.
Xiaolan He, Tingting Li, Xiao Wang
wiley +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
GABAergic neurons in the ventrolateral periaqueductal gray mediate fentanyl withdrawal and self-administration in mice. [PDF]
Chen Y +5 more
europepmc +1 more source
Nicotine targets epigenetic mechanisms in selected populations of telencephalic GABAergic neurons.
Nicotine targets epigenetic mechanisms in selected populations of telencephalic GABAergic ...
Rosalba. Satta (7949768)
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